Gene description for IFT172
Gene name intraflagellar transport 172
Gene symbol IFT172
Other names/aliases NPHP17
SLB
SRTD10
osm-1
wim
Species Homo sapiens
 Database cross references - IFT172
ExoCarta ExoCarta_26160
Vesiclepedia VP_26160
Entrez Gene 26160
HGNC 30391
MIM 607386
UniProt Q9UG01  
 IFT172 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for IFT172
Biological Process
    neural tube closure GO:0001843 IEA
    heart looping GO:0001947 IEA
    Notch signaling pathway GO:0007219 IEA
    smoothened signaling pathway GO:0007224 IEA
    brain development GO:0007420 IEA
    epidermis development GO:0008544 IEA
    dorsal/ventral pattern formation GO:0009953 IEA
    negative regulation of keratinocyte proliferation GO:0010839 IEA
    protein processing GO:0016485 IEA
    spinal cord motor neuron differentiation GO:0021522 IEA
    cytoplasmic microtubule organization GO:0031122 IEA
    intraciliary anterograde transport GO:0035720 NAS
    intraciliary transport GO:0042073 IBA
    keratinocyte proliferation GO:0043616 IEA
    negative regulation of smoothened signaling pathway GO:0045879 IEA
    positive regulation of smoothened signaling pathway GO:0045880 IEA
    embryonic camera-type eye morphogenesis GO:0048596 IEA
    roof of mouth development GO:0060021 IEA
    limb development GO:0060173 IEA
    cilium assembly GO:0060271 IDA
    cilium assembly GO:0060271 ISS
    cilium assembly GO:0060271 NAS
    bone development GO:0060348 IEA
    hindgut development GO:0061525 IEA
    left/right axis specification GO:0070986 IEA
    non-motile cilium assembly GO:1905515 IEA
Subcellular Localization
    cilium GO:0005929 ISS
    cilium GO:0005929 NAS
    cilium GO:0005929 TAS
    axoneme GO:0005930 IBA
    intraciliary transport particle B GO:0030992 IBA
    intraciliary transport particle B GO:0030992 IPI
    intraciliary transport particle B GO:0030992 ISS
    ciliary basal body GO:0036064 IBA
    sperm midpiece GO:0097225 IEA
    sperm principal piece GO:0097228 IEA
    ciliary tip GO:0097542 TAS
    sperm cytoplasmic droplet GO:0097598 IEA
    extracellular vesicle GO:1903561 HDA
 Experiment description of studies that identified IFT172 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 834
MISEV standards
EM
Biophysical techniques
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 835
MISEV standards
EM
Biophysical techniques
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for IFT172
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DNAJC7 7266
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 IFT80 57560
Affinity Capture-MS Homo sapiens
3 LHX4  
Reconstituted Complex Homo sapiens
4 IFT27 11020
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 TTC30A 92104
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 ICK  
Affinity Capture-MS Homo sapiens
7 TTC26 79989
Affinity Capture-MS Homo sapiens
8 TRAK1 22906
Affinity Capture-MS Homo sapiens
9 TP53 7157
Affinity Capture-MS Homo sapiens
10 IFT20 90410
Affinity Capture-MS Homo sapiens
11 CLUAP1 23059
Affinity Capture-MS Homo sapiens
12 KIF3B 9371
Co-fractionation Homo sapiens
13 SNAPC4  
Affinity Capture-MS Homo sapiens
14 DNAJA2 10294
Affinity Capture-MS Homo sapiens
15 ISOC2  
Affinity Capture-MS Homo sapiens
16 TRAF3IP1 26146
Affinity Capture-MS Homo sapiens
17 HSPB11 51668
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 IFT57 55081
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 SQSTM1 8878
Proximity Label-MS Homo sapiens
20 DUSP16  
Affinity Capture-MS Homo sapiens
21 KRBA1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 TTC30B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 ABTB2 25841
Affinity Capture-MS Homo sapiens
24 TSC22D4 81628
Affinity Capture-MS Homo sapiens
25 IFT46 56912
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 NUDC 10726
Affinity Capture-MS Homo sapiens
27 IFT74 80173
Affinity Capture-MS Homo sapiens
28 FGF8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 TFPI2 7980
Affinity Capture-MS Homo sapiens
30 IFT52 51098
Affinity Capture-MS Homo sapiens
31 LHX3  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
32 IFT88 8100
Affinity Capture-MS Homo sapiens
33 KXD1 79036
Affinity Capture-MS Homo sapiens
34 CORO1A 11151
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 KRT2 3849
Affinity Capture-MS Homo sapiens
36 PCM1 5108
Proximity Label-MS Homo sapiens
37 CCDC96  
Affinity Capture-MS Homo sapiens
38 ZC2HC1C  
Affinity Capture-MS Homo sapiens
39 IFT81 28981
Affinity Capture-MS Homo sapiens
40 IFT22 64792
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here