Gene description for SFR1
Gene name SWI5-dependent recombination repair 1
Gene symbol SFR1
Other names/aliases C10orf78
MEI5
MEIR5
bA373N18.1
Species Homo sapiens
 Database cross references - SFR1
ExoCarta ExoCarta_119392
Vesiclepedia VP_119392
Entrez Gene 119392
HGNC 29574
UniProt Q86XK3  
 SFR1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for SFR1
Molecular Function
    protein binding GO:0005515 IPI
    nuclear receptor coactivator activity GO:0030374 IBA
    nuclear receptor coactivator activity GO:0030374 IDA
Biological Process
    double-strand break repair via homologous recombination GO:0000724 IBA
    double-strand break repair via homologous recombination GO:0000724 IMP
    positive regulation of DNA-templated transcription GO:0045893 IBA
    positive regulation of DNA-templated transcription GO:0045893 IDA
    cellular response to estrogen stimulus GO:0071391 IDA
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISS
    nucleoplasm GO:0005654 IDA
    nucleolus GO:0005730 IDA
    centrosome GO:0005813 IDA
    Swi5-Sfr1 complex GO:0032798 IBA
    Swi5-Sfr1 complex GO:0032798 IDA
 Experiment description of studies that identified SFR1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SFR1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PLA2G4E  
Affinity Capture-MS Homo sapiens
2 RNF40 9810
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
3 RNASE7 84659
Affinity Capture-MS Homo sapiens
4 EXOC1 55763
Two-hybrid Homo sapiens
5 SERPINA12  
Affinity Capture-MS Homo sapiens
6 SERPINB7 8710
Affinity Capture-MS Homo sapiens
7 SWI5 375757
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
8 ALOXE3  
Affinity Capture-MS Homo sapiens
9 CTSV 1515
Affinity Capture-MS Homo sapiens
10 NMI  
Two-hybrid Homo sapiens
11 TRAF3IP1 26146
Two-hybrid Homo sapiens
12 S100A2 6273
Affinity Capture-MS Homo sapiens
13 PBRM1 55193
Negative Genetic Homo sapiens
14 KLK7 5650
Affinity Capture-MS Homo sapiens
15 HMBOX1  
Two-hybrid Homo sapiens
16 ALOX12B  
Affinity Capture-MS Homo sapiens
17 MRFAP1L1  
Two-hybrid Homo sapiens
18 HAL 3034
Affinity Capture-MS Homo sapiens
19 DTNBP1  
Two-hybrid Homo sapiens
20 GSDMA 284110
Affinity Capture-MS Homo sapiens
21 MNAT1  
Co-fractionation Homo sapiens
22 CEP70  
Two-hybrid Homo sapiens
23 RINT1 60561
Two-hybrid Homo sapiens
24 NDC80 10403
Two-hybrid Homo sapiens
25 TGM1 7051
Affinity Capture-MS Homo sapiens
26 RBP1 5947
Affinity Capture-MS Homo sapiens
27 TFIP11  
Two-hybrid Homo sapiens
28 SDR9C7  
Affinity Capture-MS Homo sapiens
29 SERPINB1 1992
Affinity Capture-MS Homo sapiens
30 RAD51  
Reconstituted Complex Homo sapiens
31 CDC5L 988
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which SFR1 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here