Gene description for HACE1
Gene name HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
Gene symbol HACE1
Other names/aliases -
Species Homo sapiens
 Database cross references - HACE1
ExoCarta ExoCarta_57531
Vesiclepedia VP_57531
Entrez Gene 57531
HGNC 21033
MIM 610876
UniProt Q8IYU2  
 HACE1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for HACE1
Molecular Function
    ubiquitin-protein transferase activity GO:0004842 IDA
    protein binding GO:0005515 IPI
    small GTPase binding GO:0031267 IDA
    small GTPase binding GO:0031267 IPI
    ubiquitin protein ligase activity GO:0061630 IBA
Biological Process
    ubiquitin-dependent protein catabolic process GO:0006511 IBA
    ubiquitin-dependent protein catabolic process GO:0006511 IDA
    Golgi organization GO:0007030 IBA
    Golgi organization GO:0007030 IDA
    protein ubiquitination GO:0016567 IDA
    Rac protein signal transduction GO:0016601 TAS
    regulation of cell migration GO:0030334 IMP
    membrane fusion GO:0061025 IBA
    membrane fusion GO:0061025 IMP
    protein K48-linked ubiquitination GO:0070936 IDA
Subcellular Localization
    Golgi membrane GO:0000139 IBA
    Golgi membrane GO:0000139 IDA
    nucleus GO:0005634 IBA
    cytoplasm GO:0005737 IBA
    endoplasmic reticulum GO:0005783 IDA
    nuclear body GO:0016604 IDA
    Golgi cisterna membrane GO:0032580 IEA
 Experiment description of studies that identified HACE1 in exosomes
1
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for HACE1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Unc45b  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
Affinity Capture-MS Mus musculus
2 Actn1 109711
Affinity Capture-MS Mus musculus
3 YBX1 4904
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
4 Hsp90ab1 15516
Affinity Capture-MS Mus musculus
5 Serpinh1 12406
Affinity Capture-MS Mus musculus
6 RARA 5914
Affinity Capture-Western Homo sapiens
7 Tmod3 50875
Affinity Capture-MS Mus musculus
8 Hspa8 15481
Affinity Capture-MS Mus musculus
9 Eif5a 276770
Affinity Capture-MS Mus musculus
10 Myh9 17886
Affinity Capture-MS Mus musculus
11 Tubb5 22154
Affinity Capture-MS Mus musculus
12 Vcl 22330
Affinity Capture-MS Mus musculus
13 CCNC  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
14 Tpm4  
Affinity Capture-MS Mus musculus
15 Vim 22352
Affinity Capture-MS Mus musculus
16 Tpm1 22003
Affinity Capture-MS Mus musculus
17 Tcp1 21454
Affinity Capture-MS Mus musculus
18 Cald1  
Affinity Capture-MS Mus musculus
19 Marcks 17118
Affinity Capture-MS Mus musculus
20 UBE2L3 7332
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
21 Tpm2  
Affinity Capture-MS Mus musculus
22 Capza1 12340
Affinity Capture-MS Mus musculus
23 RARB  
Affinity Capture-Western Homo sapiens
24 Hspd1 15510
Affinity Capture-MS Mus musculus
25 Tubb4a 22153
Affinity Capture-MS Mus musculus
26 OPTN 10133
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
27 POTEF 728378
Affinity Capture-MS Homo sapiens
28 RAB4A 5867
Reconstituted Complex Homo sapiens
29 IRF7  
Affinity Capture-MS Homo sapiens
30 UBE2D2 7322
Reconstituted Complex Homo sapiens
31 Sqstm1  
Affinity Capture-Western Mus musculus
32 Fhl1  
Affinity Capture-MS Mus musculus
33 Flnb 286940
Affinity Capture-MS Mus musculus
34 Actn4 60595
Affinity Capture-MS Mus musculus
35 Cnn2  
Affinity Capture-MS Mus musculus
36 Csrp1 13007
Affinity Capture-MS Mus musculus
37 Actg1 11465
Affinity Capture-MS Mus musculus
38 RAB11A 8766
Proximity Label-MS Homo sapiens
39 Actc1 11464
Affinity Capture-MS Mus musculus
40 HACE1 57531
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
41 Npm1 18148
Affinity Capture-MS Mus musculus
42 Gsn 227753
Affinity Capture-MS Mus musculus
Affinity Capture-Western Mus musculus
43 Tpm3 59069
Affinity Capture-MS Mus musculus
44 NOXA1  
Affinity Capture-Western Homo sapiens
45 Flna 192176
Affinity Capture-MS Mus musculus
46 Coro1c 23790
Affinity Capture-MS Mus musculus
47 RAC1 5879
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
48 Hspa9 15526
Affinity Capture-MS Mus musculus
49 Cct8 12469
Affinity Capture-MS Mus musculus
50 Capza2 12343
Affinity Capture-MS Mus musculus
51 Capzb 12345
Affinity Capture-MS Mus musculus
52 RARG  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
53 Plec 18810
Affinity Capture-MS Mus musculus
54 Lima1  
Affinity Capture-MS Mus musculus
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