Gene description for MYO9A
Gene name myosin IXA
Gene symbol MYO9A
Other names/aliases -
Species Homo sapiens
 Database cross references - MYO9A
ExoCarta ExoCarta_4649
Vesiclepedia VP_4649
Entrez Gene 4649
HGNC 7608
MIM 604875
UniProt B2RTY4  
 MYO9A identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for MYO9A
Molecular Function
    microfilament motor activity GO:0000146 IBA
    GTPase activator activity GO:0005096 TAS
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    metal ion binding GO:0046872 IEA
    actin filament binding GO:0051015 IBA
Biological Process
    visual perception GO:0007601 TAS
    cell junction assembly GO:0034329 IMP
    intracellular signal transduction GO:0035556 IEA
    establishment of epithelial cell apical/basal polarity GO:0045198 IBA
    establishment of epithelial cell apical/basal polarity GO:0045198 IMP
    regulation of small GTPase mediated signal transduction GO:0051056 TAS
    regulation of neuron projection arborization GO:0150011 ISS
Subcellular Localization
    cytosol GO:0005829 TAS
    actin filament GO:0005884 IBA
    membrane GO:0016020 IEA
    unconventional myosin complex GO:0016461 NAS
    axonal growth cone GO:0044295 IBA
    axonal growth cone GO:0044295 ISS
    synapse GO:0045202 IEA
 Experiment description of studies that identified MYO9A in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for MYO9A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TRIM52  
Affinity Capture-MS Homo sapiens
2 HSPE1 3336
Affinity Capture-MS Homo sapiens
3 DKK3 27122
Affinity Capture-MS Homo sapiens
4 NHP2 55651
Affinity Capture-MS Homo sapiens
5 PLEC 5339
Affinity Capture-MS Homo sapiens
6 POLR2M  
Two-hybrid Homo sapiens
7 PDDC1 347862
Affinity Capture-MS Homo sapiens
8 RASGEF1A  
Affinity Capture-MS Homo sapiens
9 SLC31A1 1317
Affinity Capture-MS Homo sapiens
10 PPP2R2B 5521
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 KCNA2  
Affinity Capture-MS Homo sapiens
12 SNRPE 6635
Affinity Capture-MS Homo sapiens
13 TTYH1  
Affinity Capture-MS Homo sapiens
14 HSD17B10 3028
Affinity Capture-MS Homo sapiens
15 CASC1  
Affinity Capture-MS Homo sapiens
16 TMOD4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 MAGEA9  
Affinity Capture-MS Homo sapiens
18 LDLRAD1  
Affinity Capture-MS Homo sapiens
19 UNC45A 55898
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 NCAPH2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 CHMP4C 92421
Affinity Capture-MS Homo sapiens
22 DQX1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 P4HA2 8974
Affinity Capture-MS Homo sapiens
24 CRYL1 51084
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 CKB 1152
Affinity Capture-MS Homo sapiens
26 MRPS17 51373
Affinity Capture-MS Homo sapiens
27 MTNR1A  
Two-hybrid Homo sapiens
28 EGFR 1956
Affinity Capture-MS Homo sapiens
29 BPNT1 10380
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 SAMD3  
Affinity Capture-MS Homo sapiens
31 MYL6B 140465
Affinity Capture-MS Homo sapiens
32 SHMT2 6472
Affinity Capture-MS Homo sapiens
33 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
34 NUP98 4928
Affinity Capture-MS Homo sapiens
35 SOX2  
Affinity Capture-MS Homo sapiens
36 TP53 7157
Affinity Capture-MS Homo sapiens
37 NXF1 10482
Affinity Capture-RNA Homo sapiens
38 CDC42 998
Two-hybrid Homo sapiens
39 FUBP3 8939
Affinity Capture-MS Homo sapiens
40 APEX1 328
Affinity Capture-RNA Homo sapiens
41 PFN1 5216
Proximity Label-MS Homo sapiens
42 LZTS2 84445
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 SKAP1 8631
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 PPP4R1L  
Affinity Capture-MS Homo sapiens
45 MRFAP1L1  
Affinity Capture-MS Homo sapiens
46 NEK10 152110
Affinity Capture-MS Homo sapiens
47 ABTB2 25841
Affinity Capture-MS Homo sapiens
48 CDC16 8881
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 MOV10 4343
Affinity Capture-RNA Homo sapiens
50 MYC  
Affinity Capture-MS Homo sapiens
51 IMPDH2 3615
Affinity Capture-MS Homo sapiens
52 MCM2 4171
Affinity Capture-MS Homo sapiens
53 JADE2 23338
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 SSSCA1 10534
Affinity Capture-MS Homo sapiens
55 PNMA2  
Affinity Capture-MS Homo sapiens
56 C14orf166 51637
Affinity Capture-MS Homo sapiens
57 ACRBP  
Affinity Capture-MS Homo sapiens
58 CREB3  
Affinity Capture-MS Homo sapiens
59 KRT40  
Affinity Capture-MS Homo sapiens
60 Naa10  
Affinity Capture-MS Mus musculus
61 SF3B3 23450
Affinity Capture-MS Homo sapiens
62 GSDMC  
Affinity Capture-MS Homo sapiens
63 RHOB 388
Proximity Label-MS Homo sapiens
64 KRT38 8687
Affinity Capture-MS Homo sapiens
65 ATP5H 10476
Affinity Capture-MS Homo sapiens
66 RHOA 387
FRET Homo sapiens
67 NEUROG3  
Affinity Capture-MS Homo sapiens
68 AK9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 LURAP1  
Affinity Capture-MS Homo sapiens
70 KRT2 3849
Affinity Capture-MS Homo sapiens
71 TBC1D15 64786
Affinity Capture-MS Homo sapiens
72 UBXN6 80700
Affinity Capture-MS Homo sapiens
73 CAPN2 824
Affinity Capture-MS Homo sapiens
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