Gene description for SLC9A3
Gene name solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
Gene symbol SLC9A3
Other names/aliases NHE3
Species Homo sapiens
 Database cross references - SLC9A3
ExoCarta ExoCarta_6550
Vesiclepedia VP_6550
Entrez Gene 6550
HGNC 11073
MIM 182307
UniProt P48764  
 SLC9A3 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for SLC9A3
Molecular Function
    protein binding GO:0005515 IPI
    sodium:proton antiporter activity GO:0015385 IBA
    sodium:proton antiporter activity GO:0015385 IDA
    sodium:proton antiporter activity GO:0015385 ISS
    sodium:proton antiporter activity GO:0015385 TAS
    potassium:proton antiporter activity GO:0015386 IBA
    PDZ domain binding GO:0030165 ISS
    phosphatidylinositol binding GO:0035091 IDA
    identical protein binding GO:0042802 IDA
Biological Process
    monoatomic ion transport GO:0006811 TAS
    regulation of intracellular pH GO:0051453 IBA
    regulation of intracellular pH GO:0051453 IDA
    potassium ion transmembrane transport GO:0071805 IBA
    sodium ion import across plasma membrane GO:0098719 IBA
    sodium ion import across plasma membrane GO:0098719 IDA
    proton transmembrane transport GO:1902600 IEA
Subcellular Localization
    early endosome GO:0005769 IDA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISS
    plasma membrane GO:0005886 TAS
    brush border GO:0005903 ISS
    cell surface GO:0009986 ISS
    apical plasma membrane GO:0016324 IBA
    apical plasma membrane GO:0016324 ISS
    brush border membrane GO:0031526 IBA
    brush border membrane GO:0031526 ISS
    early endosome membrane GO:0031901 IEA
    recycling endosome membrane GO:0055038 IDA
    extracellular exosome GO:0070062 HDA
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified SLC9A3 in exosomes
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for SLC9A3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 CHP2  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
3 PDZK1 5174
Two-hybrid Homo sapiens
4 SLC9A3R2 9351
Reconstituted Complex Homo sapiens
5 Slc9a3r1 26941
Two-hybrid Mus musculus
6 NEDD4L 23327
Affinity Capture-Western Homo sapiens
7 CHP1 11261
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
8 SLC9A3R1 9368
Affinity Capture-Western Homo sapiens
9 USP48  
Affinity Capture-Western Homo sapiens
10 DRD3  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here