Gene description for MARS2
Gene name methionyl-tRNA synthetase 2, mitochondrial
Gene symbol MARS2
Other names/aliases MetRS
mtMetRS
Species Homo sapiens
 Database cross references - MARS2
ExoCarta ExoCarta_92935
Vesiclepedia VP_92935
Entrez Gene 92935
HGNC 25133
MIM 609728
UniProt Q96GW9  
 MARS2 identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for MARS2
Molecular Function
    methionine-tRNA ligase activity GO:0004825 IBA
    methionine-tRNA ligase activity GO:0004825 IDA
    methionine-tRNA ligase activity GO:0004825 TAS
    ATP binding GO:0005524 IEA
Biological Process
    tRNA aminoacylation for protein translation GO:0006418 TAS
    methionyl-tRNA aminoacylation GO:0006431 IBA
    methionyl-tRNA aminoacylation GO:0006431 IDA
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrial matrix GO:0005759 IDA
    mitochondrial matrix GO:0005759 TAS
 Experiment description of studies that identified MARS2 in sEVs
1
Experiment ID 235
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for MARS2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MTSS1L 92154
Affinity Capture-MS Homo sapiens
2 RIT1 6016
Negative Genetic Homo sapiens
3 SMURF2 64750
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 UQCRFS1 7386
Affinity Capture-MS Homo sapiens
5 MRPL4 51073
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 ALDOC 230
Co-fractionation Homo sapiens
7 BCKDHB 594
Affinity Capture-MS Homo sapiens
8 ACSM5 54988
Affinity Capture-MS Homo sapiens
9 CLPP 8192
Proximity Label-MS Homo sapiens
10 RPA2 6118
Proximity Label-MS Homo sapiens
11 GCDH 2639
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 TRUB2  
Affinity Capture-MS Homo sapiens
13 SLC9A3R2 9351
Co-fractionation Homo sapiens
14 NDUFS7 374291
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 CLUH 23277
Affinity Capture-MS Homo sapiens
16 SIRT3  
Affinity Capture-MS Homo sapiens
17 SSX7  
Affinity Capture-MS Homo sapiens
18 APP 351
Reconstituted Complex Homo sapiens
19 MAG  
Affinity Capture-MS Homo sapiens
20 FAM219A 203259
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 SSC4D  
Affinity Capture-MS Homo sapiens
22 RPA3 6119
Proximity Label-MS Homo sapiens
23 SIPA1L2  
Affinity Capture-MS Homo sapiens
24 OGT 8473
Reconstituted Complex Homo sapiens
25 GPR182  
Affinity Capture-MS Homo sapiens
26 MYL10 93408
Affinity Capture-MS Homo sapiens
27 FCGR2B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 HINT2 84681
Affinity Capture-MS Homo sapiens
29 KRAS 3845
Negative Genetic Homo sapiens
30 NDUFB11 54539
Affinity Capture-MS Homo sapiens
31 FAM19A2 338811
Affinity Capture-MS Homo sapiens
32 GCSAML  
Affinity Capture-MS Homo sapiens
33 HSPD1 3329
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 YBEY  
Affinity Capture-MS Homo sapiens
35 MALSU1  
Affinity Capture-MS Homo sapiens
36 MTHFD1L 25902
Affinity Capture-MS Homo sapiens
37 CDKN2C  
Affinity Capture-MS Homo sapiens
38 C17orf53  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which MARS2 is involved
PathwayEvidenceSource
Metabolism of proteins TAS Reactome
Mitochondrial tRNA aminoacylation TAS Reactome
Translation TAS Reactome
tRNA Aminoacylation TAS Reactome





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