Gene description for ANKRD17
Gene name ankyrin repeat domain 17
Gene symbol ANKRD17
Other names/aliases GTAR
MASK2
NY-BR-16
Species Homo sapiens
 Database cross references - ANKRD17
ExoCarta ExoCarta_26057
Vesiclepedia VP_26057
Entrez Gene 26057
HGNC 23575
MIM 615929
UniProt O75179  
 ANKRD17 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Hepatocytes 26054723    
 Gene ontology annotations for ANKRD17
Molecular Function
    chromatin binding GO:0003682 IDA
    RNA binding GO:0003723 HDA
    protein binding GO:0005515 IPI
Biological Process
    blood vessel maturation GO:0001955 IEA
    regulation of DNA replication GO:0006275 IMP
    defense response to bacterium GO:0042742 IDA
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 IDA
    innate immune response GO:0045087 IBA
    innate immune response GO:0045087 IDA
    positive regulation of cell cycle GO:0045787 IMP
    negative regulation of smooth muscle cell differentiation GO:0051151 IEA
    positive regulation of G1/S transition of mitotic cell cycle GO:1900087 IMP
    positive regulation of MDA-5 signaling pathway GO:1900245 IDA
    positive regulation of RIG-I signaling pathway GO:1900246 IDA
Subcellular Localization
    chromatin GO:0000785 IDA
    male germ cell nucleus GO:0001673 IEA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    membrane GO:0016020 HDA
    nuclear membrane GO:0031965 IDA
 Experiment description of studies that identified ANKRD17 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for ANKRD17
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Co-fractionation Homo sapiens
2 MSH6 2956
Co-fractionation Homo sapiens
3 HOXA7  
Affinity Capture-MS Homo sapiens
4 S100A6 6277
Affinity Capture-MS Homo sapiens
5 CSNK1A1 1452
Affinity Capture-MS Homo sapiens
6 PHLPP1  
Proximity Label-MS Homo sapiens
7 EPB41L5 57669
Affinity Capture-MS Homo sapiens
8 MAGEA1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 RPL10 6134
Affinity Capture-MS Homo sapiens
10 PNMAL1  
Affinity Capture-MS Homo sapiens
11 FGF3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 DBX2  
Affinity Capture-MS Homo sapiens
13 SOX2  
Affinity Capture-MS Homo sapiens
14 ZNF414  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 HOXB6 3216
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 CAPZB 832
Affinity Capture-MS Homo sapiens
17 RPS20 6224
Proximity Label-MS Homo sapiens
18 AKAP17A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 MEAF6  
Affinity Capture-MS Homo sapiens
20 HOXA5  
Affinity Capture-MS Homo sapiens
21 CREB1  
Affinity Capture-MS Homo sapiens
22 FBL 2091
Proximity Label-MS Homo sapiens
23 FGF17  
Affinity Capture-MS Homo sapiens
24 SYT2  
Affinity Capture-MS Homo sapiens
25 TCEANC2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 XYLT1 64131
Affinity Capture-MS Homo sapiens
27 ITGA4 3676
Affinity Capture-MS Homo sapiens
28 MYCN  
Affinity Capture-MS Homo sapiens
29 ZNF780A  
Affinity Capture-MS Homo sapiens
30 CPEB1  
Proximity Label-MS Homo sapiens
31 TRIM41 90933
Affinity Capture-MS Homo sapiens
32 DDOST 1650
Affinity Capture-MS Homo sapiens
33 BSPRY 54836
Affinity Capture-MS Homo sapiens
34 CDKN1A  
Affinity Capture-MS Homo sapiens
35 QPRT 23475
Affinity Capture-MS Homo sapiens
36 RPL5 6125
Affinity Capture-MS Homo sapiens
37 ANKHD1 54882
Affinity Capture-MS Homo sapiens
38 NTRK1 4914
Affinity Capture-MS Homo sapiens
39 FGF8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 GLI3 2737
Proximity Label-MS Homo sapiens
41 ADH6 130
Two-hybrid Homo sapiens
42 CBX6  
Affinity Capture-MS Homo sapiens
43 SMC1A 8243
Cross-Linking-MS (XL-MS) Homo sapiens
44 TGIF2LY  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 FGFRL1 53834
Affinity Capture-MS Homo sapiens
46 RPS16 6217
Affinity Capture-MS Homo sapiens
47 TRMT2A 27037
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 APC  
Two-hybrid Homo sapiens
49 CDX1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 CT45A5  
Affinity Capture-MS Homo sapiens
51 LHX9  
Affinity Capture-MS Homo sapiens
52 SIX2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 RPL11 6135
Affinity Capture-MS Homo sapiens
54 PPP1R12B 4660
Affinity Capture-MS Homo sapiens
55 HPSE2  
Affinity Capture-MS Homo sapiens
56 FGFBP1 9982
Affinity Capture-MS Homo sapiens
57 WHAMMP3  
Affinity Capture-MS Homo sapiens
58 IRF9 10379
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 RC3H2  
Affinity Capture-MS Homo sapiens
60 SIRT7  
Affinity Capture-MS Homo sapiens
61 PHIP 55023
Affinity Capture-MS Homo sapiens
62 NR3C1 2908
Proximity Label-MS Homo sapiens
63 HOXB7 3217
Affinity Capture-MS Homo sapiens
64 BAP1 8314
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 FOSL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 HOXD4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 AURKB 9212
Affinity Capture-MS Homo sapiens
68 MAP2K3 5606
Affinity Capture-MS Homo sapiens
69 HOXA4  
Affinity Capture-MS Homo sapiens
70 FOS 2353
Affinity Capture-MS Homo sapiens
71 PSPC1 55269
Affinity Capture-MS Homo sapiens
72 LDLR 3949
Positive Genetic Homo sapiens
73 HOXC4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 HSPA1A 3303
Affinity Capture-MS Homo sapiens
75 GAS2L2  
Affinity Capture-MS Homo sapiens
76 KIAA0368 23392
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
77 CCDC140  
Affinity Capture-MS Homo sapiens
78 ZC3H3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 FHL2 2274
Affinity Capture-MS Homo sapiens
80 MDM2  
Two-hybrid Homo sapiens
81 ZNF263  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 STX11 8676
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 OST4  
Affinity Capture-MS Homo sapiens
84 C6orf222  
Affinity Capture-MS Homo sapiens
85 ZRANB1 54764
Affinity Capture-MS Homo sapiens
86 SFRP4 6424
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
88 FGF11  
Affinity Capture-MS Homo sapiens
89 SIRT6  
Affinity Capture-MS Homo sapiens
90 ILF3 3609
Affinity Capture-MS Homo sapiens
91 FBXL6  
Affinity Capture-MS Homo sapiens
92 CAPN1 823
Affinity Capture-MS Homo sapiens
93 LONP1 9361
Affinity Capture-MS Homo sapiens
94 UTP23  
Affinity Capture-MS Homo sapiens
95 NUP35 129401
Proximity Label-MS Homo sapiens
96 OVOL2  
Affinity Capture-MS Homo sapiens
97 DDX58 23586
Affinity Capture-RNA Homo sapiens
98 RBM23  
Affinity Capture-MS Homo sapiens
99 NEIL1  
Affinity Capture-MS Homo sapiens
100 ITSN2 50618
Two-hybrid Homo sapiens
101 HOXC8  
Affinity Capture-MS Homo sapiens
102 SERBP1 26135
Proximity Label-MS Homo sapiens
103 STT3B 201595
Affinity Capture-MS Homo sapiens
104 RAB5C 5878
Affinity Capture-MS Homo sapiens
105 SRP9 6726
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ANKRD17 is involved
No pathways found





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