Gene description for TSNAX
Gene name translin-associated factor X
Gene symbol TSNAX
Other names/aliases TRAX
Species Homo sapiens
 Database cross references - TSNAX
ExoCarta ExoCarta_7257
Entrez Gene 7257
HGNC 12380
MIM 602964
UniProt Q99598  
 TSNAX identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for TSNAX
Molecular Function
    protein transporter activity GO:0008565 TAS
    single-stranded DNA binding GO:0003697 IBA
    poly(A) RNA binding GO:0044822 IDA
    DNA binding GO:0003677 TAS
    protein binding GO:0005515 IPI
    endoribonuclease activity GO:0004521 IBA
    sequence-specific DNA binding GO:0043565 IBA
    metal ion binding GO:0046872 IEA
Biological Process
    multicellular organismal development GO:0007275 IEA
    RNA phosphodiester bond hydrolysis, endonucleolytic GO:0090502 IBA
    spermatogenesis GO:0007283 IEA
    gene expression GO:0010467 TAS
    protein transport GO:0015031 TAS
    cell differentiation GO:0030154 IEA
Subcellular Localization
    cytosol GO:0005829 TAS
    cytoplasm GO:0005737 IBA
    perinuclear region of cytoplasm GO:0048471 IEA
    nucleus GO:0005634 IEA
    Golgi apparatus GO:0005794 IEA
 Experiment description of studies that identified TSNAX in exosomes
1
Experiment ID 126
ISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
2
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TSNAX
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GADD45G  
Two-hybrid Homo sapiens
2 C1D  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
3 MRFAP1L1  
Two-hybrid Homo sapiens
4 PBXIP1  
Two-hybrid Homo sapiens
5 TSN 7247
Two-hybrid Homo sapiens
6 Tsn 22099
Reconstituted Complex Mus musculus
View the network image/svg+xml
 Pathways in which TSNAX is involved
PathwayEvidenceSource
Small interfering RNA (siRNA) biogenesis TAS Reactome





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