Gene description for GEMIN8
Gene name gem (nuclear organelle) associated protein 8
Gene symbol GEMIN8
Other names/aliases FAM51A1
Species Homo sapiens
 Database cross references - GEMIN8
ExoCarta ExoCarta_54960
Vesiclepedia VP_54960
Entrez Gene 54960
HGNC 26044
UniProt Q9NWZ8  
 GEMIN8 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for GEMIN8
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    spliceosomal snRNP assembly GO:0000387 EXP
    spliceosomal snRNP assembly GO:0000387 IBA
    spliceosomal snRNP assembly GO:0000387 IDA
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    SMN complex GO:0032797 IBA
    SMN complex GO:0032797 IDA
    SMN complex GO:0032797 IPI
    SMN-Sm protein complex GO:0034719 IDA
    Gemini of coiled bodies GO:0097504 IEA
 Experiment description of studies that identified GEMIN8 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for GEMIN8
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RN7SL1 6029
Protein-RNA Homo sapiens
2 PFN2 5217
Affinity Capture-MS Homo sapiens
3 CD40 958
Affinity Capture-MS Homo sapiens
4 HAX1  
Proximity Label-MS Homo sapiens
5 SIGLECL1  
Affinity Capture-MS Homo sapiens
6 SNRPG 6637
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 SMN1 6606
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 SNRPE 6635
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 GEMIN2 8487
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 FGF14  
Affinity Capture-MS Homo sapiens
11 BTNL9  
Affinity Capture-MS Homo sapiens
12 RNU1-1 26871
Protein-RNA Homo sapiens
13 CPNE7 27132
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 KLHL8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 DNAJA2 10294
Proximity Label-MS Homo sapiens
16 GEMIN6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 GEMIN5 25929
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 RNU2-1  
Protein-RNA Homo sapiens
19 SNRPA 6626
Affinity Capture-MS Homo sapiens
20 PTPN9 5780
Affinity Capture-MS Homo sapiens
21 USP9X 8239
Affinity Capture-Western Homo sapiens
22 NCKIPSD 51517
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
23 SMN2 6607
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 FUS 2521
Affinity Capture-MS Homo sapiens
25 SNRPF 6636
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 SNRPD2 6633
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 APP 351
Reconstituted Complex Homo sapiens
28 STRAP 11171
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 DNAJB8  
Proximity Label-MS Homo sapiens
30 GEMIN4 50628
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 COMTD1 118881
Affinity Capture-MS Homo sapiens
32 LSM7  
Affinity Capture-MS Homo sapiens
33 DDX20 11218
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 SNRNP70 6625
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 MYO6 4646
Affinity Capture-MS Homo sapiens
36 PHAX  
Affinity Capture-MS Homo sapiens
37 SNRPN 6638
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 DDRGK1 65992
Affinity Capture-MS Homo sapiens
39 DNAJB13  
Proximity Label-MS Homo sapiens
40 SNRPC 6631
Affinity Capture-MS Homo sapiens
41 KRAS 3845
Negative Genetic Homo sapiens
42 GEMIN7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 FXYD3 5349
Affinity Capture-MS Homo sapiens
44 FAXC  
Affinity Capture-MS Homo sapiens
45 Snrnp70 20637
Affinity Capture-MS Mus musculus
46 ITCH 83737
Affinity Capture-Western Homo sapiens
47 Smn1 20595
Affinity Capture-MS Mus musculus
48 SNRPB 6628
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 P2RY12 64805
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 SNRPD3 6634
Affinity Capture-MS Homo sapiens
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