Gene description for SNTA1
Gene name syntrophin, alpha 1
Gene symbol SNTA1
Other names/aliases LQT12
SNT1
TACIP1
dJ1187J4.5
Species Homo sapiens
 Database cross references - SNTA1
ExoCarta ExoCarta_6640
Vesiclepedia VP_6640
Entrez Gene 6640
HGNC 11167
MIM 601017
UniProt Q13424  
 SNTA1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Hepatocellular carcinoma cells 26054723    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for SNTA1
Molecular Function
    actin binding GO:0003779 IEA
    structural molecule activity GO:0005198 IEA
    protein binding GO:0005515 IPI
    calmodulin binding GO:0005516 IEA
    sodium channel regulator activity GO:0017080 IBA
    sodium channel regulator activity GO:0017080 IMP
    PDZ domain binding GO:0030165 IEA
    transmembrane transporter binding GO:0044325 IBA
    transmembrane transporter binding GO:0044325 IPI
    nitric-oxide synthase binding GO:0050998 IPI
    ATPase binding GO:0051117 IPI
Biological Process
    regulation of heart rate GO:0002027 IMP
    regulation of vasoconstriction by circulating norepinephrine GO:0003117 IEA
    muscle contraction GO:0006936 TAS
    neuromuscular junction development GO:0007528 IEA
    regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307 IMP
    ventricular cardiac muscle cell action potential GO:0086005 IBA
    ventricular cardiac muscle cell action potential GO:0086005 IMP
    negative regulation of peptidyl-cysteine S-nitrosylation GO:1902083 IMP
    regulation of sodium ion transmembrane transport GO:1902305 IMP
Subcellular Localization
    cytoplasm GO:0005737 IEA
    cytoskeleton GO:0005856 IEA
    dystrophin-associated glycoprotein complex GO:0016010 IBA
    syntrophin complex GO:0016013 TAS
    lateral plasma membrane GO:0016328 TAS
    neuromuscular junction GO:0031594 IBA
    protein-containing complex GO:0032991 IDA
    sarcolemma GO:0042383 IBA
    postsynaptic membrane GO:0045211 IEA
    anchoring junction GO:0070161 IEA
 Experiment description of studies that identified SNTA1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 236
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
6
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for SNTA1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GNAT3 346562
Affinity Capture-MS Homo sapiens
2 GLS 2744
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
3 SNTG1  
Affinity Capture-MS Homo sapiens
4 UTRN 7402
Affinity Capture-MS Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-MS Homo sapiens
5 PLCB3 5331
Affinity Capture-MS Homo sapiens
6 STAM 8027
Affinity Capture-MS Homo sapiens
7 GRB2 2885
Affinity Capture-Western Homo sapiens
8 SNTB2 6645
Affinity Capture-MS Homo sapiens
9 SNTG2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 RYR2 6262
Affinity Capture-MS Homo sapiens
11 CFAP69  
Affinity Capture-MS Homo sapiens
12 DTNA  
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
13 ABCC4 10257
Reconstituted Complex Homo sapiens
14 NEB 4703
Affinity Capture-MS Homo sapiens
15 MAPK12  
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
16 PLEKHA2 59339
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
17 C15orf59  
Affinity Capture-MS Homo sapiens
18 MAGEE1  
Affinity Capture-Western Homo sapiens
19 DGKZ  
Reconstituted Complex Homo sapiens
20 Sstr2  
Two-hybrid Rattus norvegicus
21 SPZ1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 DTNB 1838
Affinity Capture-MS Homo sapiens
23 KCNJ4  
Affinity Capture-Western Homo sapiens
24 RGS11  
Affinity Capture-MS Homo sapiens
25 NDEL1 81565
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 TNS2 23371
Affinity Capture-MS Homo sapiens
27 XRCC6 2547
Two-hybrid Homo sapiens
28 DMD 1756
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
29 HMG20A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 SLC34A3  
Affinity Capture-MS Homo sapiens
31 KCNJ12 3768
Affinity Capture-MS Homo sapiens
32 SCN1A  
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
33 SCN5A 6331
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
34 NOS1  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
35 TAGAP  
Affinity Capture-MS Homo sapiens
36 BAI1  
Protein-peptide Homo sapiens
View the network image/svg+xml
 Pathways in which SNTA1 is involved
No pathways found





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