Gene description for ALDH6A1
Gene name aldehyde dehydrogenase 6 family, member A1
Gene symbol ALDH6A1
Other names/aliases MMSADHA
MMSDH
Species Homo sapiens
 Database cross references - ALDH6A1
ExoCarta ExoCarta_4329
Vesiclepedia VP_4329
Entrez Gene 4329
HGNC 7179
MIM 603178
UniProt Q02252  
 ALDH6A1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for ALDH6A1
Molecular Function
    RNA binding GO:0003723 HDA
    methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity GO:0004491 IBA
    methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity GO:0004491 IMP
    methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity GO:0004491 ISS
    methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity GO:0004491 TAS
    malonate-semialdehyde dehydrogenase (acetylating) activity GO:0018478 IEA
Biological Process
    thymine catabolic process GO:0006210 IBA
    thymine catabolic process GO:0006210 IMP
    valine metabolic process GO:0006573 ISS
    valine catabolic process GO:0006574 IBA
    valine catabolic process GO:0006574 IMP
    branched-chain amino acid catabolic process GO:0009083 TAS
    thymine metabolic process GO:0019859 ISS
    brown fat cell differentiation GO:0050873 IEA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IDA
    mitochondrion GO:0005739 NAS
    mitochondrial matrix GO:0005759 TAS
 Experiment description of studies that identified ALDH6A1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 126
MISEV standards
✘ Biophysical techniques
✔
GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for ALDH6A1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 POLG2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 CLPP 8192
Proximity Label-MS Homo sapiens
3 HSPE1 3336
Co-fractionation Homo sapiens
4 ALDH7A1 501
Co-fractionation Homo sapiens
5 HIBADH 11112
Co-fractionation Homo sapiens
6 COX5B 1329
Affinity Capture-MS Homo sapiens
7 PITPNB 23760
Co-fractionation Homo sapiens
8 ALDH4A1 8659
Co-fractionation Homo sapiens
9 GPI 2821
Co-fractionation Homo sapiens
10 FAH 2184
Co-fractionation Homo sapiens
11 ANXA7 310
Co-fractionation Homo sapiens
12 ALDH8A1 64577
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 ALDH2 217
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 LAMP2 3920
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 CYP1A1  
Affinity Capture-MS Homo sapiens
16 FAHD1 81889
Affinity Capture-MS Homo sapiens
17 PARK2  
Affinity Capture-MS Homo sapiens
18 FAM175A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 BIRC6 57448
Affinity Capture-MS Homo sapiens
20 BEX4  
Affinity Capture-MS Homo sapiens
21 DEFB136  
Affinity Capture-MS Homo sapiens
22 DUSP12 11266
Affinity Capture-MS Homo sapiens
23 OGT 8473
Reconstituted Complex Homo sapiens
24 GSTK1 373156
Co-fractionation Homo sapiens
25 SPR 6697
Co-fractionation Homo sapiens
26 TPI1 7167
Co-fractionation Homo sapiens
27 HOXC5  
Affinity Capture-MS Homo sapiens
28 RPL35A 6165
Affinity Capture-MS Homo sapiens
29 HIBCH 26275
Co-fractionation Homo sapiens
30 FAXC  
Co-fractionation Homo sapiens
31 RABIF  
Affinity Capture-MS Homo sapiens
32 OR1D4  
Affinity Capture-MS Homo sapiens
33 PTCD1 26024
Affinity Capture-MS Homo sapiens
34 GYG2  
Co-fractionation Homo sapiens
35 LMO2  
Two-hybrid Homo sapiens
36 NDUFS7 374291
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ALDH6A1 is involved
PathwayEvidenceSource
Branched-chain amino acid catabolism TAS Reactome
Metabolism TAS Reactome
Metabolism of amino acids and derivatives TAS Reactome





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