Gene description for BLOC1S5
Gene name biogenesis of lysosomal organelles complex-1, subunit 5, muted
Gene symbol BLOC1S5
Other names/aliases BLOS5
MU
MUTED
Species Homo sapiens
 Database cross references - BLOC1S5
ExoCarta ExoCarta_63915
Vesiclepedia VP_63915
Entrez Gene 63915
HGNC 18561
MIM 607289
UniProt Q8TDH9  
 BLOC1S5 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
Saliva 19199708    
 Gene ontology annotations for BLOC1S5
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    anterograde axonal transport GO:0008089 ISS
    vesicle-mediated transport GO:0016192 IEA
    neuron projection development GO:0031175 ISS
    melanosome transport GO:0032402 IDA
    melanosome organization GO:0032438 NAS
    otolith morphogenesis GO:0032474 IEA
    endosome to melanosome transport GO:0035646 IDA
    anterograde synaptic vesicle transport GO:0048490 ISS
    positive regulation of pigment cell differentiation GO:0050942 IDA
Subcellular Localization
    transport vesicle GO:0030133 IDA
    BLOC-1 complex GO:0031083 IBA
    BLOC-1 complex GO:0031083 IDA
    BLOC-1 complex GO:0031083 IPI
    axon cytoplasm GO:1904115 IEA
    microvesicle GO:1990742 IEA
 Experiment description of studies that identified BLOC1S5 in exosomes
1
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 66
MISEV standards
IEM
Biophysical techniques
TSG101|Alix|CD63|CD81
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors "Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR"
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for BLOC1S5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LRRC15 131578
Affinity Capture-MS Homo sapiens
2 PKNOX1  
Two-hybrid Homo sapiens
3 SERGEF  
Affinity Capture-MS Homo sapiens
4 KRT27 342574
Affinity Capture-MS Homo sapiens
5 WHAMMP3  
Affinity Capture-MS Homo sapiens
6 BLOC1S6  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
7 BLOC1S2 282991
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
8 XPO1 7514
Affinity Capture-MS Homo sapiens
9 HSBP1 3281
Two-hybrid Homo sapiens
10 TEX35  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 S100A2 6273
Affinity Capture-MS Homo sapiens
12 SQSTM1 8878
Affinity Capture-MS Homo sapiens
13 SNAPIN 23557
Affinity Capture-MS Homo sapiens
14 PBX2  
Two-hybrid Homo sapiens
15 HIST1H1B 3009
Affinity Capture-MS Homo sapiens
16 BLOC1S3 388552
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
17 BCAS4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 APP 351
Reconstituted Complex Homo sapiens
19 BRK1 55845
Affinity Capture-MS Homo sapiens
20 ABI3 51225
Two-hybrid Homo sapiens
21 BLOC1S1  
Affinity Capture-MS Homo sapiens
22 DTNBP1  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
23 ABI2 10152
Two-hybrid Homo sapiens
24 DCUN1D1 54165
Affinity Capture-MS Homo sapiens
25 SELENBP1 8991
Affinity Capture-MS Homo sapiens
26 BLOC1S4 55330
Affinity Capture-MS Homo sapiens
27 DSG4 147409
Affinity Capture-MS Homo sapiens
28 TSNAX 7257
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
29 KXD1 79036
Affinity Capture-MS Homo sapiens
30 TRIM69 140691
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 HIST2H2AC 8338
Affinity Capture-MS Homo sapiens
32 CSNK1E 1454
Affinity Capture-MS Homo sapiens
33 OIP5  
Two-hybrid Homo sapiens
34 MEF2BNB  
Affinity Capture-MS Homo sapiens
35 C17orf59 54785
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 HUWE1 10075
Affinity Capture-MS Homo sapiens
37 YOD1  
Affinity Capture-MS Homo sapiens
38 SNAP29 9342
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which BLOC1S5 is involved
No pathways found





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