Gene description for CD8B
Gene name CD8b molecule
Gene symbol CD8B
Other names/aliases CD8B1
LEU2
LY3
LYT3
P37
Species Homo sapiens
 Database cross references - CD8B
ExoCarta ExoCarta_926
Vesiclepedia VP_926
Entrez Gene 926
HGNC 1707
MIM 186730
UniProt P10966  
 CD8B identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for CD8B
Molecular Function
    protein binding GO:0005515 IPI
    coreceptor activity GO:0015026 NAS
    MHC class I protein binding GO:0042288 NAS
Biological Process
    adaptive immune response GO:0002250 NAS
    immune response GO:0006955 NAS
    cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 NAS
    T cell activation GO:0042110 IDA
    T cell activation GO:0042110 NAS
    T cell receptor signaling pathway GO:0050852 IDA
Subcellular Localization
    extracellular region GO:0005576 IEA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 TAS
    cell surface GO:0009986 IBA
    early endosome membrane GO:0031901 TAS
    T cell receptor complex GO:0042101 NAS
    receptor complex GO:0043235 ISO
 Experiment description of studies that identified CD8B in exosomes
1
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CD8B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SBDS 51119
Affinity Capture-MS Homo sapiens
2 GALNT12 79695
Affinity Capture-MS Homo sapiens
3 TMED8 283578
Affinity Capture-MS Homo sapiens
4 SRC 6714
Affinity Capture-MS Homo sapiens
5 CD8A 925
Co-localization Homo sapiens
6 ERGIC2 51290
Affinity Capture-MS Homo sapiens
7 PRSS2 5645
Affinity Capture-MS Homo sapiens
8 FGFR1 2260
Affinity Capture-MS Homo sapiens
9 ANKRD13D  
Affinity Capture-MS Homo sapiens
10 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
11 ATP1A3 478
Affinity Capture-MS Homo sapiens
12 SORT1 6272
Affinity Capture-MS Homo sapiens
13 KLRG2 346689
Affinity Capture-MS Homo sapiens
14 TMEM11 8834
Affinity Capture-MS Homo sapiens
15 TMEM214 54867
Affinity Capture-MS Homo sapiens
16 ATP6V0A2 23545
Affinity Capture-MS Homo sapiens
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