Gene description for ANKRD23
Gene name ankyrin repeat domain 23
Gene symbol ANKRD23
Other names/aliases DARP
MARP3
Species Homo sapiens
 Database cross references - ANKRD23
ExoCarta ExoCarta_200539
Vesiclepedia VP_200539
Entrez Gene 200539
HGNC 24470
MIM 610736
UniProt Q86SG2  
 ANKRD23 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for ANKRD23
Molecular Function
    transcription cis-regulatory region binding GO:0000976 IBA
    protein binding GO:0005515 IPI
    titin binding GO:0031432 IPI
Biological Process
    fatty acid metabolic process GO:0006631 IEA
    response to muscle stretch GO:0035994 IEA
    positive regulation of transcription by RNA polymerase II GO:0045944 IBA
    regulation of sarcomere organization GO:0060297 IEA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleoplasm GO:0005654 IDA
    cytosol GO:0005829 IDA
    intercalated disc GO:0014704 IEA
    actin cytoskeleton GO:0015629 IDA
    I band GO:0031674 IEA
 Experiment description of studies that identified ANKRD23 in exosomes
1
Experiment ID 224
MISEV standards
EM|AFM
Biophysical techniques
Alix|TSG101|CD63|CD81
Enriched markers
GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for ANKRD23
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CCDC57 284001
Two-hybrid Homo sapiens
2 MYPN 84665
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
3 CDCA7L  
Two-hybrid Homo sapiens
4 ENKD1  
Two-hybrid Homo sapiens
5 MIPOL1  
Two-hybrid Homo sapiens
6 CLIC3 9022
Two-hybrid Homo sapiens
7 HOOK1  
Two-hybrid Homo sapiens
8 HRAS 3265
Reconstituted Complex Homo sapiens
9 POLR3C 10623
Two-hybrid Homo sapiens
10 GRB2 2885
Two-hybrid Homo sapiens
11 TTN 7273
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
12 FAM90A1  
Two-hybrid Homo sapiens
13 TRIM41 90933
Two-hybrid Homo sapiens
14 KIFC3 3801
Two-hybrid Homo sapiens
15 CCDC102B  
Two-hybrid Homo sapiens
16 IQUB  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which ANKRD23 is involved
No pathways found





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