Gene description for CSNK1G3
Gene name casein kinase 1, gamma 3
Gene symbol CSNK1G3
Other names/aliases CKI-gamma 3
CSNK1G3L
Species Homo sapiens
 Database cross references - CSNK1G3
ExoCarta ExoCarta_1456
Vesiclepedia VP_1456
Entrez Gene 1456
HGNC 2456
MIM 604253
UniProt Q9Y6M4  
 CSNK1G3 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Mesenchymal stem cells 36408942    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for CSNK1G3
Molecular Function
    protein kinase activity GO:0004672 TAS
    protein serine/threonine kinase activity GO:0004674 IBA
    protein serine/threonine kinase activity GO:0004674 IDA
    3-phosphoinositide-dependent protein kinase activity GO:0004676 IEA
    DNA-dependent protein kinase activity GO:0004677 IEA
    AMP-activated protein kinase activity GO:0004679 IEA
    eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 IEA
    ribosomal protein S6 kinase activity GO:0004711 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    histone H3S10 kinase activity GO:0035175 IEA
    histone H3T11 kinase activity GO:0035402 IEA
    histone H3T6 kinase activity GO:0035403 IEA
    histone H2AXS139 kinase activity GO:0035979 IEA
    histone H3S28 kinase activity GO:0044022 IEA
    histone H4S1 kinase activity GO:0044023 IEA
    histone H2AS1 kinase activity GO:0044024 IEA
    histone H2BS14 kinase activity GO:0044025 IEA
    histone H3T3 kinase activity GO:0072354 IEA
    histone H2AS121 kinase activity GO:0072371 IEA
    Rho-dependent protein serine/threonine kinase activity GO:0072518 IEA
    protein serine kinase activity GO:0106310 IEA
    histone H2BS36 kinase activity GO:0140823 IEA
    histone H3S57 kinase activity GO:0140855 IEA
    histone H3T45 kinase activity GO:0140857 IEA
    histone H2AT120 kinase activity GO:1990244 IEA
Biological Process
    chromatin remodeling GO:0006338 IEA
    endocytosis GO:0006897 IBA
    signal transduction GO:0007165 IBA
    Wnt signaling pathway GO:0016055 IEA
    protein modification process GO:0036211 TAS
    positive regulation of canonical Wnt signaling pathway GO:0090263 IBA
Subcellular Localization
    nucleus GO:0005634 IBA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IEA
    plasma membrane GO:0005886 IBA
 Experiment description of studies that identified CSNK1G3 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 363
MISEV standards
Biophysical techniques
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
DCLK1
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 364
MISEV standards
Biophysical techniques
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
DCLK1
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 365
MISEV standards
Biophysical techniques
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
DCLK1
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
9
Experiment ID 211
MISEV standards
EM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
cytochrome c|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
10
Experiment ID 212
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
Cytochrome C|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CSNK1G3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CACNG5  
Affinity Capture-MS Homo sapiens
2 ANLN 54443
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 LAMP3  
Proximity Label-MS Homo sapiens
4 WASF2 10163
Affinity Capture-MS Homo sapiens
5 S1PR2 9294
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 CSNK1G2 1455
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 LIMA1 51474
Affinity Capture-MS Homo sapiens
8 MDFI  
Two-hybrid Homo sapiens
9 LAMP2 3920
Proximity Label-MS Homo sapiens
10 Actb 11461
Affinity Capture-MS Mus musculus
11 FAXC  
Affinity Capture-MS Homo sapiens
12 LAMTOR1 55004
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 RD3  
Affinity Capture-MS Homo sapiens
14 YES1 7525
Affinity Capture-MS Homo sapiens
15 KRTAP10-10  
Two-hybrid Homo sapiens
16 ALPK2  
Affinity Capture-MS Homo sapiens
17 YWHAG 7532
Affinity Capture-MS Homo sapiens
18 SLC31A1 1317
Affinity Capture-MS Homo sapiens
19 CRCP  
Affinity Capture-MS Homo sapiens
20 RAB35 11021
Proximity Label-MS Homo sapiens
21 MYCN  
Affinity Capture-MS Homo sapiens
22 ABI1 10006
Affinity Capture-MS Homo sapiens
23 NCSTN 23385
Affinity Capture-MS Homo sapiens
24 KCNA4  
Affinity Capture-MS Homo sapiens
25 KIF14 9928
Affinity Capture-MS Homo sapiens
26 GPR156  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 MRPL34  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 CYP2S1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 WASF1 8936
Affinity Capture-MS Homo sapiens
30 TSPAN3 10099
Affinity Capture-MS Homo sapiens
31 LYN 4067
Proximity Label-MS Homo sapiens
32 MCAM 4162
Proximity Label-MS Homo sapiens
33 DRICH1  
Two-hybrid Homo sapiens
34 CERS2 29956
Affinity Capture-MS Homo sapiens
35 GJB7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 DNAJC5 80331
Affinity Capture-MS Homo sapiens
37 PTP4A3  
Affinity Capture-MS Homo sapiens
38 KIAA1522 57648
Affinity Capture-MS Homo sapiens
39 ARRDC3 57561
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 APBA1  
Affinity Capture-MS Homo sapiens
41 Coro1c 23790
Affinity Capture-MS Mus musculus
42 MRAP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 ANKRD13A 88455
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 DUSP22  
Affinity Capture-MS Homo sapiens
45 TPX2  
Affinity Capture-MS Homo sapiens
46 CSNK1G3 1456
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
47 TUBB 203068
Affinity Capture-MS Homo sapiens
48 BTNL9  
Affinity Capture-MS Homo sapiens
49 SDC1 6382
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 MARCH1  
Affinity Capture-MS Homo sapiens
51 UBXN7 26043
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
52 NCKAP1 10787
Affinity Capture-MS Homo sapiens
53 LAMP1 3916
Proximity Label-MS Homo sapiens
54 DBNDD2  
Two-hybrid Homo sapiens
55 LAMTOR2 28956
Affinity Capture-MS Homo sapiens
56 YWHAZ 7534
Affinity Capture-MS Homo sapiens
57 ANKRD13D  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 ARF6 382
Proximity Label-MS Homo sapiens
59 CSNK1G1 53944
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 BAIAP2L1 55971
Affinity Capture-MS Homo sapiens
61 TCIRG1 10312
Affinity Capture-MS Homo sapiens
62 SYNPO 11346
Affinity Capture-MS Homo sapiens
63 TADA2A  
Affinity Capture-MS Homo sapiens
64 MYC  
Affinity Capture-MS Homo sapiens
65 RHOB 388
Proximity Label-MS Homo sapiens
66 TPCN2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 ATP6V0A1 535
Affinity Capture-MS Homo sapiens
68 SLC22A4 6583
Affinity Capture-MS Homo sapiens
69 OCLM  
Affinity Capture-MS Homo sapiens
70 BAIAP2 10458
Affinity Capture-MS Homo sapiens
71 IRF3 3661
Affinity Capture-MS Homo sapiens
72 FLOT1 10211
Affinity Capture-MS Homo sapiens
73 MALL  
Affinity Capture-MS Homo sapiens
74 SLC25A41  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 TSPAN10 83882
Affinity Capture-MS Homo sapiens
76 SLC37A3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
77 EIF1AD 84285
Affinity Capture-MS Homo sapiens
78 SERHL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 EDIL3 10085
Affinity Capture-MS Homo sapiens
80 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
81 RNF11 26994
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 NSF 4905
Affinity Capture-MS Homo sapiens
83 TP53 7157
Affinity Capture-MS Homo sapiens
84 CXCL6  
Affinity Capture-MS Homo sapiens
85 SAA1 6288
Affinity Capture-MS Homo sapiens
86 FLOT2 2319
Affinity Capture-MS Homo sapiens
87 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
88 DDX58 23586
Affinity Capture-RNA Homo sapiens
89 CACUL1  
Affinity Capture-MS Homo sapiens
90 PPP1R14A 94274
Reconstituted Complex Homo sapiens
91 UBB 7314
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 MED21  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 ABI2 10152
Affinity Capture-MS Homo sapiens
94 RAB2A 5862
Proximity Label-MS Homo sapiens
95 TMEM257  
Affinity Capture-MS Homo sapiens
96 RPL23 9349
Affinity Capture-MS Homo sapiens
97 RAB11A 8766
Proximity Label-MS Homo sapiens
98 GAGE5  
Affinity Capture-MS Homo sapiens
99 EPHA2 1969
Proximity Label-MS Homo sapiens
100 ZNF641  
Affinity Capture-MS Homo sapiens
101 ISG20  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
102 KRAS 3845
Proximity Label-MS Homo sapiens
103 RAB5C 5878
Proximity Label-MS Homo sapiens
104 CYFIP1 23191
Affinity Capture-MS Homo sapiens
105 CAV1 857
Proximity Label-MS Homo sapiens
106 ARIH1 25820
Affinity Capture-MS Homo sapiens
107 PROSER2 254427
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CSNK1G3 is involved
No pathways found





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