Gene description for PCDHGB4
Gene name protocadherin gamma subfamily B, 4
Gene symbol PCDHGB4
Other names/aliases CDH20
FIB2
PCDH-GAMMA-B4
Species Homo sapiens
 Database cross references - PCDHGB4
ExoCarta ExoCarta_8641
Vesiclepedia VP_8641
Entrez Gene 8641
HGNC 8711
MIM 603058
UniProt Q9UN71  
 PCDHGB4 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for PCDHGB4
Molecular Function
    calcium ion binding GO:0005509 IEA
Biological Process
    cell adhesion GO:0007155 IBA
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 IEA
    nervous system development GO:0007399 IEA
    calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules GO:0016339 NAS
Subcellular Localization
    plasma membrane GO:0005886 IBA
    membrane GO:0016020 NAS
 Experiment description of studies that identified PCDHGB4 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PCDHGB4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RNF149 284996
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 C2CD2L 9854
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 MARK3 4140
Affinity Capture-MS Homo sapiens
4 CENPN  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 PCDHGB1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 SDCBP 6386
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 RPL23 9349
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 PTPRD 5789
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 DHRS7 51635
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 CELSR3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 PCDHGB5 56101
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 DAG1 1605
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 PDZD8 118987
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 LETM1 3954
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 ATP13A2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 TMEM63B 55362
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 EIF2AK3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 CYP51A1 1595
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 POP4 10775
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 TYW1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 EPHX1 2052
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 TAB1 10454
Affinity Capture-MS Homo sapiens
23 POM121  
Affinity Capture-MS Homo sapiens
24 SAMD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 TMEM59L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 IL1RAP 3556
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 HIST1H2BD 3017
Cross-Linking-MS (XL-MS) Homo sapiens
28 GHDC  
Affinity Capture-MS Homo sapiens
29 OPA3 80207
Affinity Capture-MS Homo sapiens
30 BTN2A2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 GRAMD1A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 SMPD2 6610
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 PIGA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 POMT1 10585
Affinity Capture-MS Homo sapiens
35 PCDHGB2  
Affinity Capture-MS Homo sapiens
36 SLC27A6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 EMILIN2 84034
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 DNMT3B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 RETSAT 54884
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 DAGLB 221955
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 PCDH10 57575
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 YIF1A 10897
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 AREL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 FAM171A2 284069
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 PCDHGB3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 ST7L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 CBX6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 PTPRK 5796
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 ZNF518A 9849
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 LTBP1 4052
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 TPP2 7174
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 PTPRU  
Affinity Capture-MS Homo sapiens
53 TMEM132A 54972
Affinity Capture-MS Homo sapiens
54 LEMD3  
Affinity Capture-MS Homo sapiens
55 ACVR2B  
Affinity Capture-MS Homo sapiens
56 ATP2A3 489
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 TOM1L1 10040
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 GRAMD1B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PCDHGB4 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here