Gene description for TMBIM6
Gene name transmembrane BAX inhibitor motif containing 6
Gene symbol TMBIM6
Other names/aliases BAXI1
BI-1
TEGT
Species Homo sapiens
 Database cross references - TMBIM6
ExoCarta ExoCarta_7009
Vesiclepedia VP_7009
Entrez Gene 7009
HGNC 11723
MIM 600748
UniProt P55061  
 TMBIM6 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Melanoma cells 25950383    
Melanoma cells 25950383    
Melanoma cells 25950383    
Melanoma cells 25950383    
Melanoma cells 25950383    
 Gene ontology annotations for TMBIM6
Molecular Function
    calcium channel activity GO:0005262 IBA
    protein binding GO:0005515 IPI
    enzyme binding GO:0019899 IPI
    ubiquitin protein ligase binding GO:0031625 IPI
    endoribonuclease inhibitor activity GO:0060698 IBA
    endoribonuclease inhibitor activity GO:0060698 IDA
Biological Process
    negative regulation of immunoglobulin production GO:0002638 IEA
    autophagy GO:0006914 IEA
    negative regulation of calcium ion transport into cytosol GO:0010523 IDA
    endoplasmic reticulum calcium ion homeostasis GO:0032469 IEA
    negative regulation of RNA splicing GO:0033119 IDA
    cellular response to unfolded protein GO:0034620 IBA
    cellular response to unfolded protein GO:0034620 IDA
    neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0036483 IEA
    negative regulation of apoptotic process GO:0043066 IGI
    negative regulation of endoribonuclease activity GO:0060702 IBA
    negative regulation of endoribonuclease activity GO:0060702 IDA
    calcium ion transmembrane transport GO:0070588 IEA
    response to L-glutamate GO:1902065 IDA
    negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GO:1902236 IDA
    negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway GO:1903298 IDA
    negative regulation of apoptotic signaling pathway GO:2001234 IBA
    negative regulation of apoptotic signaling pathway GO:2001234 IDA
Subcellular Localization
    nucleus GO:0005634 TAS
    cytoplasm GO:0005737 IDA
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 IBA
    endoplasmic reticulum membrane GO:0005789 IDA
    plasma membrane GO:0005886 TAS
    membrane GO:0016020 HDA
    membrane GO:0016020 NAS
 Experiment description of studies that identified TMBIM6 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 254
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1|CD81
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name MNT-1
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 255
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name G1
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 256
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name 501mel
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 257
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name Daju
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
9
Experiment ID 260
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1|CD81
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name 1205Lu
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for TMBIM6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GPR151  
Two-hybrid Homo sapiens
2 JSRP1  
Two-hybrid Homo sapiens
3 ATG9A 79065
Affinity Capture-MS Homo sapiens
4 KIAA2013 90231
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 GLP1R  
PCA Homo sapiens
6 PI16  
Two-hybrid Homo sapiens
7 CD79A  
Two-hybrid Homo sapiens
8 FFAR1  
Affinity Capture-MS Homo sapiens
9 GJB4  
Two-hybrid Homo sapiens
10 MS4A3  
Two-hybrid Homo sapiens
11 SERINC2 347735
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 GPHB5  
Two-hybrid Homo sapiens
13 UGT2B11  
Two-hybrid Homo sapiens
14 RNF5  
Affinity Capture-MS Homo sapiens
15 TREML1 340205
Two-hybrid Homo sapiens
16 LIME1 54923
Two-hybrid Homo sapiens
17 OPRM1 4988
Two-hybrid Homo sapiens
18 SLAMF6 114836
Two-hybrid Homo sapiens
19 MANBAL 63905
Two-hybrid Homo sapiens
20 HIATL1 84641
Two-hybrid Homo sapiens
21 ST8SIA4 7903
Affinity Capture-MS Homo sapiens
22 IL17RC 84818
Affinity Capture-MS Homo sapiens
23 GPX8 493869
Two-hybrid Homo sapiens
24 SYT9 143425
Two-hybrid Homo sapiens
25 SLC12A7 10723
Two-hybrid Homo sapiens
26 BFAR  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
27 VTI1A 143187
Two-hybrid Homo sapiens
28 CLDN22  
Two-hybrid Homo sapiens
29 SYNGR1 9145
Affinity Capture-MS Homo sapiens
30 HERPUD2  
Two-hybrid Homo sapiens
31 RNFT1  
Affinity Capture-MS Homo sapiens
32 PARK2  
Affinity Capture-MS Homo sapiens
33 RHBDL2  
Two-hybrid Homo sapiens
34 GPR35  
Affinity Capture-MS Homo sapiens
35 CERS2 29956
Two-hybrid Homo sapiens
36 CLCC1 23155
Affinity Capture-MS Homo sapiens
37 ODF4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
38 SLC7A1 6541
Two-hybrid Homo sapiens
39 LYPD1  
Affinity Capture-MS Homo sapiens
40 TMEM63A 9725
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 GZMK  
Two-hybrid Homo sapiens
42 CD300LG  
Two-hybrid Homo sapiens
43 SCN3B  
Two-hybrid Homo sapiens
44 TRPM8  
Affinity Capture-MS Homo sapiens
45 TMUB1  
Two-hybrid Homo sapiens
46 TMCO3 55002
Affinity Capture-MS Homo sapiens
47 KCNC1  
Two-hybrid Homo sapiens
48 CHRND  
Affinity Capture-MS Homo sapiens
49 PCDHA8  
Affinity Capture-MS Homo sapiens
50 CLEC5A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 GJA8  
Two-hybrid Homo sapiens
52 EXD3  
Affinity Capture-MS Homo sapiens
53 GJA5 2702
Two-hybrid Homo sapiens
54 HSD11B1 3290
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 LRRC59 55379
Two-hybrid Homo sapiens
56 RNF170 81790
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 SLC41A3 54946
Two-hybrid Homo sapiens
58 NELFCD 51497
Affinity Capture-MS Homo sapiens
59 ESAM 90952
Two-hybrid Homo sapiens
60 CHST8 64377
Affinity Capture-MS Homo sapiens
61 HTR2C  
Two-hybrid Homo sapiens
62 IER3  
Two-hybrid Homo sapiens
63 CREB3L1  
Two-hybrid Homo sapiens
64 FAM209A 200232
Two-hybrid Homo sapiens
65 EMR4P  
Affinity Capture-MS Homo sapiens
66 MAPK6  
Affinity Capture-MS Homo sapiens
67 GPR42  
Two-hybrid Homo sapiens
68 SIT1 27240
Two-hybrid Homo sapiens
69 MPPE1 65258
Affinity Capture-MS Homo sapiens
70 RNF185  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 OSBPL8 114882
Affinity Capture-MS Homo sapiens
72 HFE2  
Two-hybrid Homo sapiens
73 TMX2 51075
Two-hybrid Homo sapiens
74 C5orf46 389336
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 CD99L2 83692
Two-hybrid Homo sapiens
76 GYPA  
Two-hybrid Homo sapiens
77 ADORA2B  
Affinity Capture-MS Homo sapiens
78 TRIM13  
Affinity Capture-MS Homo sapiens
79 EDNRA 1909
Affinity Capture-MS Homo sapiens
80 HLA-DMB 3109
Affinity Capture-MS Homo sapiens
81 SOAT2  
Two-hybrid Homo sapiens
82 VAC14 55697
Affinity Capture-MS Homo sapiens
83 DUSP3 1845
Affinity Capture-MS Homo sapiens
84 ASIC4  
Affinity Capture-MS Homo sapiens
85 TEX29  
Two-hybrid Homo sapiens
86 EBP  
Two-hybrid Homo sapiens
87 REEP2  
Two-hybrid Homo sapiens
88 MMGT1 93380
Two-hybrid Homo sapiens
89 FERD3L  
Two-hybrid Homo sapiens
90 BCL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
91 KCNA10  
Two-hybrid Homo sapiens
92 SPPL2B 56928
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 ADAM33 80332
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 POMK  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 MARCH4  
Affinity Capture-MS Homo sapiens
96 VIPR1  
Affinity Capture-MS Homo sapiens
97 COX7C 1350
Affinity Capture-MS Homo sapiens
98 C9orf72  
Affinity Capture-MS Homo sapiens
99 TMEM31  
Two-hybrid Homo sapiens
100 PIANP  
Two-hybrid Homo sapiens
101 SLC1A1 6505
Affinity Capture-MS Homo sapiens
102 FGFBP2  
Two-hybrid Homo sapiens
103 STEAP1B  
Two-hybrid Homo sapiens
104 ATP13A1 57130
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which TMBIM6 is involved
No pathways found





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