Gene description for E2F6
Gene name E2F transcription factor 6
Gene symbol E2F6
Other names/aliases E2F-6
Species Homo sapiens
 Database cross references - E2F6
ExoCarta ExoCarta_1876
Entrez Gene 1876
HGNC 3120
MIM 602944
UniProt O75461  
 E2F6 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for E2F6
Molecular Function
    DNA binding GO:0003677 IEA
    sequence-specific DNA binding transcription factor activity GO:0003700 IEA
    protein binding GO:0005515 IPI
    transcription corepressor activity GO:0003714 TAS
Biological Process
    regulation of transcription involved in G1/S transition of mitotic cell cycle GO:0000083 IEA
    transcription, DNA-templated GO:0006351 IEA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 TAS
Subcellular Localization
    nucleus GO:0005634 IDA
    MLL1 complex GO:0071339 IDA
    transcription factor complex GO:0005667 IEA
 Experiment description of studies that identified E2F6 in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for E2F6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RING1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
2 TFDP2  
Invitro Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
3 BMI1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
4 TFDP1  
Invitro Homo sapiens
Two-hybrid Homo sapiens
5 PCGF6  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
6 RYBP  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which E2F6 is involved
No pathways found





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