Gene description for CXCL16
Gene name chemokine (C-X-C motif) ligand 16
Gene symbol CXCL16
Other names/aliases CXCLG16
SR-PSOX
SRPSOX
Species Homo sapiens
 Database cross references - CXCL16
ExoCarta ExoCarta_58191
Entrez Gene 58191
HGNC 16642
MIM 605398
UniProt Q9H2A7  
 CXCL16 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for CXCL16
Molecular Function
    scavenger receptor activity GO:0005044 TAS
    low-density lipoprotein receptor activity GO:0005041 ISS
    chemokine activity GO:0008009 ISS
Biological Process
    cellular response to lipopolysaccharide GO:0071222 IEA
    positive regulation of cell migration GO:0030335 IMP
    response to interferon-gamma GO:0034341 IDA
    positive regulation of cell growth GO:0030307 IMP
    T cell chemotaxis GO:0010818 IEA
    chemotaxis GO:0006935 NAS
    response to cytokine GO:0034097 IDA
    receptor-mediated endocytosis GO:0006898 NAS
    response to tumor necrosis factor GO:0034612 IDA
Subcellular Localization
    extracellular region GO:0005576 TAS
    plasma membrane GO:0005886 IEA
    extracellular space GO:0005615 IDA
    integral component of membrane GO:0016021 NAS
    membrane GO:0016020 TAS
 Experiment description of studies that identified CXCL16 in exosomes
1
Experiment ID 126
ISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for CXCL16
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CXCR6  
Invivo Homo sapiens
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which CXCL16 is involved
PathwayEvidenceSource
Chemokine receptors bind chemokines TAS Reactome
G alpha (i) signalling events TAS Reactome





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