Gene description for KLK1
Gene name kallikrein 1
Gene symbol KLK1
Other names/aliases KLKR
Klk6
hK1
Species Homo sapiens
 Database cross references - KLK1
ExoCarta ExoCarta_3816
Vesiclepedia VP_3816
Entrez Gene 3816
HGNC 6357
MIM 147910
UniProt P06870  
 KLK1 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for KLK1
Molecular Function
    serine-type endopeptidase activity GO:0004252 IBA
    serine-type endopeptidase activity GO:0004252 NAS
Biological Process
    regulation of systemic arterial blood pressure GO:0003073 IBA
    zymogen activation GO:0031638 IBA
Subcellular Localization
    extracellular space GO:0005615 IBA
    nucleus GO:0005634 IDA
    secretory granule GO:0030141 IBA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified KLK1 in exosomes
1
Experiment ID 63
MISEV standards
✘ Biophysical techniques
✔
AQP2
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for KLK1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ART5  
Affinity Capture-MS Homo sapiens
2 HSPA5 3309
Affinity Capture-MS Homo sapiens
3 AGPAT5 55326
Affinity Capture-MS Homo sapiens
4 MUM1  
Affinity Capture-MS Homo sapiens
5 FOXRED2  
Affinity Capture-MS Homo sapiens
6 SLC25A33  
Affinity Capture-MS Homo sapiens
7 IDUA 3425
Affinity Capture-MS Homo sapiens
8 DDX19B 11269
Affinity Capture-MS Homo sapiens
9 PXMP2  
Affinity Capture-MS Homo sapiens
10 PTPMT1 114971
Affinity Capture-MS Homo sapiens
11 UBA52 7311
Affinity Capture-MS Homo sapiens
12 TRMT2A 27037
Affinity Capture-MS Homo sapiens
13 TNFRSF6B  
Affinity Capture-MS Homo sapiens
14 SLC25A15  
Affinity Capture-MS Homo sapiens
15 BDNF 627
Affinity Capture-MS Homo sapiens
16 TTF2 8458
Affinity Capture-MS Homo sapiens
17 NSUN3  
Affinity Capture-MS Homo sapiens
18 SLC16A10 117247
Affinity Capture-MS Homo sapiens
19 FGFR3 2261
Affinity Capture-MS Homo sapiens
20 SEMA3B 7869
Affinity Capture-MS Homo sapiens
21 HIGD2A  
Affinity Capture-MS Homo sapiens
22 SLC25A20 788
Affinity Capture-MS Homo sapiens
23 SLC25A4 291
Affinity Capture-MS Homo sapiens
24 CRLF1 9244
Affinity Capture-MS Homo sapiens
25 CHRD  
Affinity Capture-MS Homo sapiens
26 NEK4  
Affinity Capture-MS Homo sapiens
27 OLFM2  
Affinity Capture-MS Homo sapiens
28 STC2 8614
Affinity Capture-MS Homo sapiens
29 MTX3  
Affinity Capture-MS Homo sapiens
30 SUMF1 285362
Affinity Capture-MS Homo sapiens
31 TAMM41  
Affinity Capture-MS Homo sapiens
32 C16orf58 64755
Affinity Capture-MS Homo sapiens
33 SERPINA4 5267
Reconstituted Complex Homo sapiens
34 PLAU 5328
Affinity Capture-MS Homo sapiens
35 PCSK6 5046
Affinity Capture-MS Homo sapiens
36 TUBB8 347688
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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