Gene description for TMED7
Gene name transmembrane emp24 protein transport domain containing 7
Gene symbol TMED7
Other names/aliases CGI-109
p24gamma3
p27
Species Homo sapiens
 Database cross references - TMED7
ExoCarta ExoCarta_51014
Entrez Gene 51014
HGNC 24253
UniProt Q9Y3B3  
 TMED7 identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
Thymus 23844026    
 Gene ontology annotations for TMED7
Biological Process
    protein transport GO:0015031 IEA
Subcellular Localization
    COPI vesicle coat GO:0030126 TAS
    integral component of membrane GO:0016021 IEA
    endoplasmic reticulum-Golgi intermediate compartment membrane GO:0033116 IEA
    Golgi apparatus GO:0005794 IDA
    endoplasmic reticulum-Golgi intermediate compartment GO:0005793 IDA
    endoplasmic reticulum membrane GO:0005789 IEA
    endoplasmic reticulum GO:0005783 IDA
    extracellular exosome GO:0070062 IDA
    COPII vesicle coat GO:0030127 TAS
 Experiment description of studies that identified TMED7 in exosomes
1
Experiment ID 226
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD9|FLOT1
EV Membrane markers
LMNA|H2AFX|ATP5A1|TOMM20
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting
Authors Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
2
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TMED7
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which TMED7 is involved
No pathways found





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