Gene description for Tsc2
Gene name tuberous sclerosis 2
Gene symbol Tsc2
Other names/aliases Rc
Species Rattus norvegicus
 Database cross references - Tsc2
ExoCarta ExoCarta_24855
Entrez Gene 24855
UniProt P49816  
 Tsc2 identified in exosomes derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Tsc2
Molecular Function
    protein binding GO:0005515 IPI
    protein heterodimerization activity GO:0046982 IPI
    phosphatase binding GO:0019902 ISS
    protein homodimerization activity GO:0042803 ISO
    14-3-3 protein binding GO:0071889 ISO
    GTPase activator activity GO:0005096 TAS
Biological Process
    negative regulation of protein kinase activity GO:0006469 ISO
    cell projection organization GO:0030030 IMP
    negative regulation of TOR signaling GO:0032007 ISO
    protein homooligomerization GO:0051260 IMP
    glucose import GO:0046323 ISO
    protein transport into plasma membrane raft GO:0044861 ISO
    protein heterooligomerization GO:0051291 IMP
    insulin-like growth factor receptor signaling pathway GO:0048009 ISO
    negative regulation of epithelial cell proliferation GO:0050680 IDA
    cellular response to insulin stimulus GO:0032869 ISO
    signal transduction GO:0007165 IDA
    positive chemotaxis GO:0050918 ISO
    negative regulation of phosphatidylinositol 3-kinase signaling GO:0014067 ISO
    heart development GO:0007507 ISO
    positive regulation of GTPase activity GO:0043547 IEA
    establishment of protein localization GO:0045184 IMP
    protein kinase B signaling GO:0043491 ISO
    regulation of cell cycle GO:0051726 IBA
    negative regulation of insulin receptor signaling pathway GO:0046627 IBA
    phosphatidylinositol 3-kinase signaling GO:0014065 ISO
    response to hypoxia GO:0001666 ISO
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISO
    protein localization GO:0008104 ISO
    regulation of endocytosis GO:0030100 ISO
    negative regulation of MAP kinase activity GO:0043407 IMP
    regulation of insulin receptor signaling pathway GO:0046626 ISO
    negative regulation of cell proliferation GO:0008285 ISO
    protein import into nucleus GO:0006606 ISO
    neural tube closure GO:0001843 ISO
    negative regulation of protein kinase B signaling GO:0051898 ISO
    negative regulation of Wnt signaling pathway GO:0030178 IDA
    negative regulation of cell size GO:0045792 IMP
Subcellular Localization
    dendrite GO:0030425 IDA
    neuron projection GO:0043005 IDA
    cytoskeleton GO:0005856 IDA
    cytosol GO:0005829 ISO
    protein complex GO:0043234 IDA
    nucleus GO:0005634 ISO
    caveola GO:0005901 IDA
    growth cone GO:0030426 IDA
    neuronal cell body GO:0043025 IDA
    Golgi apparatus GO:0005794 ISO
    intracellular GO:0005622 ISO
    intracellular membrane-bounded organelle GO:0043231 IDA
    cytoplasm GO:0005737 ISO
    membrane raft GO:0045121 IDA
    perinuclear region of cytoplasm GO:0048471 ISO
    membrane GO:0016020 ISO
    TSC1-TSC2 complex GO:0033596 ISO
    cell GO:0005623 ISO
 Experiment description of studies that identified Tsc2 in exosomes
Experiment ID 35
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Tsc2
  Protein Interactor ExoCarta ID Identification method PubMed Species
Two-hybrid Homo sapiens
2 MAPKAPK2 9261
Biochemical Activity Homo sapiens
3 TSC1  
Co-localization Homo sapiens
4 Cdkn1b  
Affinity Capture-Western Rattus norvegicus
5 Pam  
Affinity Capture-Western Rattus norvegicus
6 Tsc1  
Co-localization Rattus norvegicus
Co-purification Rattus norvegicus
7 YWHAB 7529
Affinity Capture-Western Homo sapiens
8 Nefl  
Co-localization Rattus norvegicus
View the network image/svg+xml

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