Gene description for CDS2
Gene name CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
Gene symbol CDS2
Other names/aliases -
Species Homo sapiens
 Database cross references - CDS2
ExoCarta ExoCarta_8760
Vesiclepedia VP_8760
Entrez Gene 8760
HGNC 1801
MIM 603549
UniProt O95674  
 CDS2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for CDS2
Molecular Function
    phosphatidate cytidylyltransferase activity GO:0004605 IDA
    phosphatidate cytidylyltransferase activity GO:0004605 NAS
    phosphatidate cytidylyltransferase activity GO:0004605 TAS
    protein binding GO:0005515 IPI
Biological Process
    phosphatidylglycerol biosynthetic process GO:0006655 TAS
    CDP-diacylglycerol biosynthetic process GO:0016024 IDA
    CDP-diacylglycerol biosynthetic process GO:0016024 IEA
    lipid droplet formation GO:0140042 IMP
Subcellular Localization
    mitochondrial inner membrane GO:0005743 TAS
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 IBA
    membrane GO:0016020 HDA
    membrane GO:0016020 ISS
 Experiment description of studies that identified CDS2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 231
MISEV standards
✘ Biophysical techniques
✔
Alix|CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 232
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 233
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
8
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
9
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for CDS2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SSR4 6748
Affinity Capture-MS Homo sapiens
2 RAMP3  
Affinity Capture-MS Homo sapiens
3 MR1  
Two-hybrid Homo sapiens
4 MGARP  
Affinity Capture-MS Homo sapiens
5 SLC31A2  
Affinity Capture-MS Homo sapiens
6 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
7 GPX8 493869
Two-hybrid Homo sapiens
8 ALDH3A2 224
Affinity Capture-MS Homo sapiens
9 NAAA  
Affinity Capture-MS Homo sapiens
10 RNF122  
Two-hybrid Homo sapiens
11 VAPA 9218
Affinity Capture-MS Homo sapiens
12 SLMAP 7871
Affinity Capture-MS Homo sapiens
13 SSMEM1  
Two-hybrid Homo sapiens
14 TP53 7157
Affinity Capture-MS Homo sapiens
15 CDS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Negative Genetic Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 PGRMC1 10857
Affinity Capture-MS Homo sapiens
17 HCST  
Affinity Capture-MS Homo sapiens
18 IGDCC4  
Affinity Capture-MS Homo sapiens
19 TNFSF8  
Affinity Capture-MS Homo sapiens
20 MTIF3  
Two-hybrid Homo sapiens
21 VSIG2  
Affinity Capture-MS Homo sapiens
22 VSIG1  
Affinity Capture-MS Homo sapiens
23 HIST1H2BG 8339
Proximity Label-MS Homo sapiens
24 TMEM184A  
Affinity Capture-MS Homo sapiens
25 GPR182  
Affinity Capture-MS Homo sapiens
26 ERGIC3 51614
Two-hybrid Homo sapiens
27 HS2ST1 9653
Affinity Capture-MS Homo sapiens
28 TSG101 7251
Two-hybrid Homo sapiens
29 NR3C1 2908
Proximity Label-MS Homo sapiens
30 EMD 2010
Affinity Capture-MS Homo sapiens
31 TMEM139  
Two-hybrid Homo sapiens
32 SRPRB 58477
Affinity Capture-MS Homo sapiens
33 TRIM55  
Two-hybrid Homo sapiens
34 CLPP 8192
Proximity Label-MS Homo sapiens
35 TMEM72  
Affinity Capture-MS Homo sapiens
36 AQP3  
Affinity Capture-MS Homo sapiens
37 MFSD4  
Affinity Capture-MS Homo sapiens
38 LRRN4CL 221091
Affinity Capture-MS Homo sapiens
39 FFAR1  
Affinity Capture-MS Homo sapiens
40 TIMMDC1  
Two-hybrid Homo sapiens
41 VSIG4  
Affinity Capture-MS Homo sapiens
42 LEUTX  
Two-hybrid Homo sapiens
43 KIAA1429 25962
Affinity Capture-MS Homo sapiens
44 FAM209A 200232
Two-hybrid Homo sapiens
45 PTDSS2 81490
Affinity Capture-MS Homo sapiens
46 SLC6A8 6535
Affinity Capture-MS Homo sapiens
47 GP5 2814
Affinity Capture-MS Homo sapiens
48 RMDN3 55177
Affinity Capture-MS Homo sapiens
49 GPR152  
Two-hybrid Homo sapiens
50 SERBP1 26135
Affinity Capture-MS Homo sapiens
51 SPPL2B 56928
Affinity Capture-MS Homo sapiens
52 HIBADH 11112
Two-hybrid Homo sapiens
53 GPR45  
Affinity Capture-MS Homo sapiens
54 CPLX4  
Two-hybrid Homo sapiens
55 HLA-B 3106
Affinity Capture-MS Homo sapiens
56 SGCA  
Affinity Capture-MS Homo sapiens
57 IL10RA  
Two-hybrid Homo sapiens
58 PTPRJ 5795
Affinity Capture-MS Homo sapiens
59 C12orf10 60314
Two-hybrid Homo sapiens
60 ASPH 444
Affinity Capture-MS Homo sapiens
61 TMEM45B 120224
Two-hybrid Homo sapiens
62 CREB3  
Two-hybrid Homo sapiens
63 INTS3 65123
Affinity Capture-MS Homo sapiens
64 CLEC2D  
Affinity Capture-MS Homo sapiens
65 VIPR1  
Affinity Capture-MS Homo sapiens
66 YIPF3 25844
Affinity Capture-MS Homo sapiens
67 SIGMAR1 10280
Affinity Capture-MS Homo sapiens
68 P2RY8  
Affinity Capture-MS Homo sapiens
69 LHFPL5  
Two-hybrid Homo sapiens
70 TSPAN12  
Two-hybrid Homo sapiens
71 GPR173  
Affinity Capture-MS Homo sapiens
72 JSRP1  
Two-hybrid Homo sapiens
73 TRIM63  
Two-hybrid Homo sapiens
74 TMX2 51075
Two-hybrid Homo sapiens
75 S1PR4  
Affinity Capture-MS Homo sapiens
76 CCDC47 57003
Affinity Capture-MS Homo sapiens
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