Gene description for AGPAT3
Gene name 1-acylglycerol-3-phosphate O-acyltransferase 3
Gene symbol AGPAT3
Other names/aliases LPAAT-GAMMA1
LPAAT3
Species Homo sapiens
 Database cross references - AGPAT3
ExoCarta ExoCarta_56894
Vesiclepedia VP_56894
Entrez Gene 56894
HGNC 326
MIM 614794
UniProt Q9NRZ7  
 AGPAT3 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for AGPAT3
Molecular Function
    1-acylglycerol-3-phosphate O-acyltransferase activity GO:0003841 IBA
    1-acylglycerol-3-phosphate O-acyltransferase activity GO:0003841 IDA
    1-acylglycerol-3-phosphate O-acyltransferase activity GO:0003841 NAS
    1-acylglycerol-3-phosphate O-acyltransferase activity GO:0003841 TAS
    protein binding GO:0005515 IPI
Biological Process
    phosphatidic acid biosynthetic process GO:0006654 TAS
    phospholipid biosynthetic process GO:0008654 NAS
    CDP-diacylglycerol biosynthetic process GO:0016024 IEA
Subcellular Localization
    Golgi membrane GO:0000139 TAS
    nuclear envelope GO:0005635 IDA
    endoplasmic reticulum GO:0005783 HDA
    endoplasmic reticulum GO:0005783 IBA
    endoplasmic reticulum membrane GO:0005789 IDA
    endoplasmic reticulum membrane GO:0005789 TAS
    plasma membrane GO:0005886 HDA
    endomembrane system GO:0012505 IBA
    membrane GO:0016020 HDA
 Experiment description of studies that identified AGPAT3 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for AGPAT3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MPP1 4354
Two-hybrid Homo sapiens
2 SIGMAR1 10280
Affinity Capture-MS Homo sapiens
3 KDELR3 11015
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 GPM6A 2823
Affinity Capture-MS Homo sapiens
5 FNDC4 64838
Affinity Capture-MS Homo sapiens
6 HSD17B11 51170
Two-hybrid Homo sapiens
7 SLC31A2  
Affinity Capture-MS Homo sapiens
8 TSPAN5 10098
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 TSPAN3 10099
Affinity Capture-MS Homo sapiens
10 CTLA4  
Affinity Capture-MS Homo sapiens
11 ATP13A3 79572
Affinity Capture-MS Homo sapiens
12 SLC6A15 55117
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 SLC18A1  
Affinity Capture-MS Homo sapiens
14 PTH1R  
Affinity Capture-MS Homo sapiens
15 ENDOD1 23052
Affinity Capture-MS Homo sapiens
16 TTYH1  
Affinity Capture-MS Homo sapiens
17 C11orf57  
Two-hybrid Homo sapiens
18 OR10H2  
Affinity Capture-MS Homo sapiens
19 HSPA8 3312
Affinity Capture-MS Homo sapiens
20 OPALIN  
Affinity Capture-MS Homo sapiens
21 SCYL1 57410
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 C4orf32  
Affinity Capture-MS Homo sapiens
23 TMEM120A 83862
Affinity Capture-MS Homo sapiens
24 CAV2 858
Affinity Capture-MS Homo sapiens
25 APOB 338
Affinity Capture-MS Homo sapiens
26 ARL15 54622
Affinity Capture-MS Homo sapiens
27 TSPAN15 23555
Affinity Capture-MS Homo sapiens
28 VKORC1L1 154807
Affinity Capture-MS Homo sapiens
29 TMEM120B  
Affinity Capture-MS Homo sapiens
30 NOMO1 23420
Affinity Capture-MS Homo sapiens
31 TMEM14B  
Two-hybrid Homo sapiens
32 CMAS 55907
Affinity Capture-MS Homo sapiens
33 TSPAN17 26262
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 GNAQ 2776
Affinity Capture-MS Homo sapiens
35 ABHD16A 7920
Two-hybrid Homo sapiens
36 NIPAL1  
Affinity Capture-MS Homo sapiens
37 IFITM3 10410
Affinity Capture-MS Homo sapiens
38 HSD17B13  
Two-hybrid Homo sapiens
39 CREB3L1  
Two-hybrid Homo sapiens
40 APP 351
Reconstituted Complex Homo sapiens
41 SERINC1 57515
Affinity Capture-MS Homo sapiens
42 KDELR1 10945
Affinity Capture-MS Homo sapiens
43 RABL3 285282
Affinity Capture-MS Homo sapiens
44 GPR52  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 TSPAN8 7103
Affinity Capture-MS Homo sapiens
46 PTK2 5747
Affinity Capture-MS Homo sapiens
47 VIPR2  
Affinity Capture-MS Homo sapiens
48 SLC39A14 23516
Affinity Capture-MS Homo sapiens
49 SPCS1 28972
Affinity Capture-MS Homo sapiens
50 BCL7B  
Affinity Capture-MS Homo sapiens
51 FAM133A 286499
Two-hybrid Homo sapiens
52 SREK1IP1  
Two-hybrid Homo sapiens
53 SOAT1 6646
Affinity Capture-MS Homo sapiens
54 PLCB3 5331
Affinity Capture-MS Homo sapiens
55 PUS7 54517
Affinity Capture-MS Homo sapiens
56 CMTM5  
Affinity Capture-MS Homo sapiens
57 SLC10A1  
Two-hybrid Homo sapiens
58 BNIP2  
Two-hybrid Homo sapiens
59 PRKCDBP 112464
Affinity Capture-MS Homo sapiens
60 NCLN 56926
Affinity Capture-MS Homo sapiens
61 FAM189A2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 CREB3  
Two-hybrid Homo sapiens
63 CMSS1  
Affinity Capture-MS Homo sapiens
64 COX7A2 1347
Affinity Capture-MS Homo sapiens
65 YIPF3 25844
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 METTL9 51108
Affinity Capture-MS Homo sapiens
67 GOLT1A  
Two-hybrid Homo sapiens
68 S1PR4  
Affinity Capture-MS Homo sapiens
69 SLC22A4 6583
Affinity Capture-MS Homo sapiens
70 WBP4  
Affinity Capture-MS Homo sapiens
71 TMEM167B  
Two-hybrid Homo sapiens
72 GPR89A  
Affinity Capture-MS Homo sapiens
73 TOM1L1 10040
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 VAPB 9217
Affinity Capture-MS Homo sapiens
75 HIATL1 84641
Two-hybrid Homo sapiens
76 TMX2 51075
Two-hybrid Homo sapiens
77 SLC7A1 6541
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 ATP2A1 487
Proximity Label-MS Homo sapiens
View the network image/svg+xml



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