Gene description for ABCD4
Gene name ATP-binding cassette, sub-family D (ALD), member 4
Gene symbol ABCD4
Other names/aliases ABC41
EST352188
MAHCJ
P70R
P79R
PMP69
PXMP1L
Species Homo sapiens
 Database cross references - ABCD4
ExoCarta ExoCarta_5826
Vesiclepedia VP_5826
Entrez Gene 5826
HGNC 68
MIM 603214
UniProt O14678  
 ABCD4 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for ABCD4
Molecular Function
    long-chain fatty acid transmembrane transporter activity GO:0005324 IBA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IBA
    ATP binding GO:0005524 NAS
    ABC-type vitamin B12 transporter activity GO:0015420 EXP
    ABC-type vitamin B12 transporter activity GO:0015420 IDA
    ABC-type vitamin B12 transporter activity GO:0015420 IMP
    ATP hydrolysis activity GO:0016887 IEA
    ATPase-coupled transmembrane transporter activity GO:0042626 IBA
    ATPase-coupled transmembrane transporter activity GO:0042626 NAS
    identical protein binding GO:0042802 IPI
Biological Process
    fatty acid beta-oxidation GO:0006635 IBA
    peroxisome organization GO:0007031 IBA
    cobalamin metabolic process GO:0009235 IDA
    cobalamin metabolic process GO:0009235 IMP
    cobalamin transport GO:0015889 IMP
    cobalamin transport GO:0015889 TAS
    long-chain fatty acid import into peroxisome GO:0015910 IBA
    very long-chain fatty acid catabolic process GO:0042760 IBA
    transmembrane transport GO:0055085 NAS
    cellular response to leukemia inhibitory factor GO:1990830 IEA
Subcellular Localization
    lysosomal membrane GO:0005765 IDA
    lysosomal membrane GO:0005765 IDA
    lysosomal membrane GO:0005765 TAS
    peroxisome GO:0005777 IDA
    peroxisome GO:0005777 IDA
    peroxisomal membrane GO:0005778 IBA
    endoplasmic reticulum membrane GO:0005789 IDA
    membrane GO:0016020 NAS
    ATP-binding cassette (ABC) transporter complex GO:0043190 NAS
 Experiment description of studies that identified ABCD4 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ABCD4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RNF149 284996
Affinity Capture-MS Homo sapiens
2 NKAIN1  
Affinity Capture-MS Homo sapiens
3 DLEU1  
Two-hybrid Homo sapiens
4 FAM189B  
Affinity Capture-MS Homo sapiens
5 SLC17A2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 KCNMB3  
Affinity Capture-MS Homo sapiens
7 HSPB2  
Two-hybrid Homo sapiens
8 KCNA2  
Affinity Capture-MS Homo sapiens
9 TTYH1  
Affinity Capture-MS Homo sapiens
10 RXFP1  
Affinity Capture-MS Homo sapiens
11 OR10H2  
Affinity Capture-MS Homo sapiens
12 ATG9A 79065
Affinity Capture-MS Homo sapiens
13 CD83  
Affinity Capture-MS Homo sapiens
14 FCGRT 2217
Affinity Capture-MS Homo sapiens
15 ZDHHC12  
Affinity Capture-MS Homo sapiens
16 PCDHA3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 CD79A  
Affinity Capture-MS Homo sapiens
18 PDGFRB 5159
Affinity Capture-MS Homo sapiens
19 FSHR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 SCAP  
Affinity Capture-MS Homo sapiens
21 AVPR1B  
Affinity Capture-MS Homo sapiens
22 KIAA1467 57613
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 TLR9  
Affinity Capture-MS Homo sapiens
24 MS4A15  
Affinity Capture-MS Homo sapiens
25 XRCC6 2547
Two-hybrid Homo sapiens
26 PCDHGC4  
Affinity Capture-MS Homo sapiens
27 ATP2B2 491
Affinity Capture-MS Homo sapiens
28 PTCHD3  
Affinity Capture-MS Homo sapiens
29 TNFRSF10A 8797
Affinity Capture-MS Homo sapiens
30 MARCH4  
Affinity Capture-MS Homo sapiens
31 ABCA2 20
Affinity Capture-MS Homo sapiens
32 GRIN2A  
Affinity Capture-MS Homo sapiens
33 PUS1 80324
Affinity Capture-MS Homo sapiens
34 PEA15 8682
Two-hybrid Homo sapiens
35 C3orf52  
Affinity Capture-MS Homo sapiens
36 KCNA5  
Affinity Capture-MS Homo sapiens
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