Gene description for LRP4
Gene name low density lipoprotein receptor-related protein 4
Gene symbol LRP4
Other names/aliases CLSS
CMS17
LRP-4
LRP10
MEGF7
SOST2
Species Homo sapiens
 Database cross references - LRP4
ExoCarta ExoCarta_4038
Vesiclepedia VP_4038
Entrez Gene 4038
HGNC 6696
MIM 604270
UniProt O75096  
 LRP4 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 19837982    
 Gene ontology annotations for LRP4
Molecular Function
    calcium ion binding GO:0005509 IEA
    protein binding GO:0005515 IPI
    coreceptor activity GO:0015026 IEA
    receptor tyrosine kinase binding GO:0030971 ISS
    apolipoprotein binding GO:0034185 IEA
    protein homodimerization activity GO:0042803 IEA
    scaffold protein binding GO:0097110 ISS
Biological Process
    kidney development GO:0001822 IDA
    hair follicle development GO:0001942 IEA
    endocytosis GO:0006897 IEA
    enzyme-linked receptor protein signaling pathway GO:0007167 IEA
    dorsal/ventral pattern formation GO:0009953 IEA
    proximal/distal pattern formation GO:0009954 IEA
    Wnt signaling pathway GO:0016055 IEA
    negative regulation of ossification GO:0030279 IMP
    positive regulation of Rac protein signal transduction GO:0035022 IEA
    odontogenesis of dentin-containing tooth GO:0042475 IEA
    embryonic digit morphogenesis GO:0042733 IEA
    generation of neurons GO:0048699 IBA
    dendrite morphogenesis GO:0048813 ISS
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IEA
    negative regulation of axonogenesis GO:0050771 ISS
    synapse organization GO:0050808 IBA
    synapse organization GO:0050808 ISS
    synaptic assembly at neuromuscular junction GO:0051124 ISS
    limb development GO:0060173 IDA
    skeletal muscle acetylcholine-gated channel clustering GO:0071340 ISS
    negative regulation of canonical Wnt signaling pathway GO:0090090 IBA
    negative regulation of canonical Wnt signaling pathway GO:0090090 IDA
    negative regulation of canonical Wnt signaling pathway GO:0090090 IMP
    postsynaptic membrane assembly GO:0097104 ISS
    presynaptic membrane assembly GO:0097105 ISS
    regulation of postsynapse assembly GO:0150052 IEA
    amyloid-beta clearance by cellular catabolic process GO:0150094 IMP
    positive regulation of presynaptic membrane organization GO:1901631 ISS
    positive regulation of skeletal muscle acetylcholine-gated channel clustering GO:1904395 IEA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 ISS
    cell surface GO:0009986 IDA
    cell surface GO:0009986 ISS
    postsynaptic density GO:0014069 ISS
    dendrite GO:0030425 ISS
    neuromuscular junction GO:0031594 ISS
    neuronal cell body GO:0043025 ISS
    plasma membrane raft GO:0044853 ISS
    synaptic membrane GO:0097060 ISS
 Experiment description of studies that identified LRP4 in exosomes
1
Experiment ID 21
MISEV standards
EM|IEM
Biophysical techniques
Alix|TSG101|HSP70|CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method
Mass spectrometry   
PubMed ID 19837982    
Organism Homo sapiens
Experiment description Proteomic and bioinformatic analysis of immunoaffinity-purified exosomes derived from the human colon tumor cell line LIM1215.
Authors "Suresh Mathivanan, Justin W.E. Lim, Bow J. Tauro, Hong Ji, Robert L. Moritz and Richard J. Simpson"
Journal name MCP
Publication year 2009
Sample Colorectal cancer cells
Sample name LIM1215
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.10-1.12 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for LRP4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CXorf66  
Affinity Capture-MS Homo sapiens
2 PID1 55022
Affinity Capture-Western Homo sapiens
PCA Homo sapiens
Affinity Capture-Western Homo sapiens
3 ZNF669  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 ZNF707  
Affinity Capture-MS Homo sapiens
5 ZNF74  
Affinity Capture-MS Homo sapiens
6 OGT 8473
Reconstituted Complex Homo sapiens
7 ZBBX  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 ZNF816  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 DFNB31  
Two-hybrid Homo sapiens
10 SP110  
Affinity Capture-MS Homo sapiens
11 ZNF621  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 LAMP3  
Proximity Label-MS Homo sapiens
13 FNDC8  
Affinity Capture-MS Homo sapiens
14 FCGRT 2217
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 FST 10468
Affinity Capture-MS Homo sapiens
16 ZNF34  
Affinity Capture-MS Homo sapiens
17 MAP10  
Affinity Capture-MS Homo sapiens
18 GDF10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 TYW3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 ZNF354C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 CUL3 8452
Affinity Capture-MS Homo sapiens
22 ZSCAN26  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 ZNF398  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 ANKRD36B  
Affinity Capture-MS Homo sapiens
25 ZNF224  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 DDX58 23586
Affinity Capture-RNA Homo sapiens
27 EMX2  
Affinity Capture-MS Homo sapiens
28 VASP 7408
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 GOLGA8G  
Affinity Capture-MS Homo sapiens
30 RAB4A 5867
Proximity Label-MS Homo sapiens
31 ZNF383  
Affinity Capture-MS Homo sapiens
32 ZNF778 197320
Affinity Capture-MS Homo sapiens
33 ZNF248  
Affinity Capture-MS Homo sapiens
34 BPHL 670
Co-fractionation Homo sapiens
35 ZNF556 80032
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 LRPAP1 4043
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 SULF2 55959
Affinity Capture-MS Homo sapiens
38 ZFP41  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 ZNF408  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 NTN5  
Affinity Capture-MS Homo sapiens
41 ARRB1 408
Affinity Capture-MS Homo sapiens
42 ZNF214  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 DEFB123  
Affinity Capture-MS Homo sapiens
44 WDR20 91833
Affinity Capture-MS Homo sapiens
45 RAB11A 8766
Proximity Label-MS Homo sapiens
46 EXOSC5 56915
Affinity Capture-MS Homo sapiens
47 BEND7 222389
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 BRD1 23774
Affinity Capture-MS Homo sapiens
49 ZNF121  
Affinity Capture-MS Homo sapiens
50 IGSF5  
Affinity Capture-MS Homo sapiens
51 ACSM3  
Affinity Capture-MS Homo sapiens
52 RPL10 6134
Affinity Capture-MS Homo sapiens
53 KRAS 3845
Proximity Label-MS Homo sapiens
54 FEZF1  
Affinity Capture-MS Homo sapiens
55 ZNF563  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 ZSCAN21  
Affinity Capture-MS Homo sapiens
57 SHPK 23729
Affinity Capture-MS Homo sapiens
58 ZNF331  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 SOST  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 ZNF17  
Affinity Capture-MS Homo sapiens
61 ADAMTS1 9510
Affinity Capture-MS Homo sapiens
62 RHOB 388
Proximity Label-MS Homo sapiens
63 TIMM13 26517
Co-fractionation Homo sapiens
64 ZNF584  
Affinity Capture-MS Homo sapiens
65 TST 7263
Co-fractionation Homo sapiens
66 IGFL3  
Affinity Capture-MS Homo sapiens
67 FAM120A 23196
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which LRP4 is involved
PathwayEvidenceSource
ECM proteoglycans IEA Reactome
Extracellular matrix organization IEA Reactome





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