Gene description for LRP2
Gene name low density lipoprotein receptor-related protein 2
Gene symbol LRP2
Other names/aliases DBS
GP330
Species Homo sapiens
 Database cross references - LRP2
ExoCarta ExoCarta_4036
Vesiclepedia VP_4036
Entrez Gene 4036
HGNC 6694
MIM 600073
UniProt P98164  
 LRP2 identified in exosomes derived from the following tissue/cell type
Urine 15326289    
Urine 19056867    
Urine 22418980    
Urine 22418980    
Urine 25452312    
 Gene ontology annotations for LRP2
Molecular Function
    low-density lipoprotein particle receptor activity GO:0005041 TAS
    calcium ion binding GO:0005509 IDA
    protein binding GO:0005515 IPI
    SH3 domain binding GO:0017124 IEA
    insulin-like growth factor I binding GO:0031994 ISS
    cargo receptor activity GO:0038024 EXP
    cargo receptor activity GO:0038024 TAS
    hormone binding GO:0042562 IBA
    protein-folding chaperone binding GO:0051087 IPI
    protein-folding chaperone binding GO:0051087 ISS
    protein transporter activity GO:0140318 ISS
Biological Process
    retinoid metabolic process GO:0001523 TAS
    kidney development GO:0001822 IEA
    neural tube closure GO:0001843 ISS
    secondary heart field specification GO:0003139 ISS
    outflow tract septum morphogenesis GO:0003148 ISS
    ventricular compact myocardium morphogenesis GO:0003223 ISS
    ventricular septum development GO:0003281 IEA
    lipid metabolic process GO:0006629 TAS
    endocytosis GO:0006897 TAS
    receptor-mediated endocytosis GO:0006898 IBA
    receptor-mediated endocytosis GO:0006898 IDA
    receptor-mediated endocytosis GO:0006898 ISS
    sensory perception of sound GO:0007605 ISS
    cell population proliferation GO:0008283 IEA
    male gonad development GO:0008584 ISS
    gene expression GO:0010467 IEA
    protein transport GO:0015031 IDA
    cobalamin transport GO:0015889 TAS
    metal ion transport GO:0030001 IDA
    negative regulation of BMP signaling pathway GO:0030514 ISS
    forebrain development GO:0030900 IEA
    diol metabolic process GO:0034311 IEA
    aorta development GO:0035904 IEA
    vitamin D metabolic process GO:0042359 TAS
    negative regulation of apoptotic process GO:0043066 IGI
    phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0043491 IGI
    response to leptin GO:0044321 IDA
    transcytosis GO:0045056 ISS
    positive regulation of neurogenesis GO:0050769 ISS
    vagina development GO:0060068 ISS
    coronary artery morphogenesis GO:0060982 ISS
    pulmonary artery morphogenesis GO:0061156 ISS
    positive regulation of oligodendrocyte progenitor proliferation GO:0070447 ISS
    cellular response to growth factor stimulus GO:0071363 ISS
    amyloid-beta clearance GO:0097242 ISS
    neuron projection arborization GO:0140058 ISS
    transport across blood-brain barrier GO:0150104 NAS
    folate import across plasma membrane GO:1904447 ISS
    cranial skeletal system development GO:1904888 IEA
    positive regulation of lysosomal protein catabolic process GO:1905167 ISS
Subcellular Localization
    lysosome GO:0005764 TAS
    lysosomal membrane GO:0005765 HDA
    endoplasmic reticulum GO:0005783 IEA
    Golgi apparatus GO:0005794 IEA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 TAS
    clathrin-coated pit GO:0005905 IEA
    external side of plasma membrane GO:0009897 ISS
    apical plasma membrane GO:0016324 IBA
    apical plasma membrane GO:0016324 IDA
    apical plasma membrane GO:0016324 ISS
    axon GO:0030424 ISS
    dendrite GO:0030425 ISS
    clathrin-coated endocytic vesicle membrane GO:0030669 TAS
    brush border membrane GO:0031526 ISS
    endosome lumen GO:0031904 IEA
    receptor complex GO:0043235 IBA
    receptor complex GO:0043235 IDA
    receptor complex GO:0043235 ISS
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified LRP2 in exosomes
1
Experiment ID 13
MISEV standards
IEM
Biophysical techniques
Alix|RAB4|RAB5B|RAB11|TSG101|CD9|AQP2|AQP1
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 15326289    
Organism Homo sapiens
Experiment description Identification and proteomic profiling of exosomes in human urine.
Authors "Pisitkun T, Shen RF, Knepper MA"
Journal name PNAS
Publication year 2004
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA XP]
Western blotting
2
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
3
Experiment ID 196
MISEV standards
EM
Biophysical techniques
Alix|TSG101|HSP70|CD9
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors "Raj DA, Fiume I, Capasso G, Pocsfalvi G."
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal high density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 197
MISEV standards
EM
Biophysical techniques
Alix|TSG101|HSP70|CD9
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors "Raj DA, Fiume I, Capasso G, Pocsfalvi G."
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal low density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
5
Experiment ID 238
MISEV standards
EM
Biophysical techniques
TSG101
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25452312    
Organism Homo sapiens
Experiment description N-linked (N-) glycoproteomics of urimary exosomes
Authors "Saraswat M, Joenvaara S, Musante L, Peltoniemi H4, Holthofer H, Renkonen R."
Journal name Mol Cell Proteomics
Publication year 2014
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Filtration
Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for LRP2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ZSCAN29  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 HOOK1  
Proximity Label-MS Homo sapiens
3 LAMP3  
Proximity Label-MS Homo sapiens
4 NOS1AP  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
5 GJA1 2697
Proximity Label-MS Homo sapiens
6 IGFBP3 3486
Affinity Capture-MS Homo sapiens
7 DLK2  
Affinity Capture-MS Homo sapiens
8 SP1  
Affinity Capture-MS Homo sapiens
9 GC 2638
Affinity Capture-Western Homo sapiens
10 DAB1 1600
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
11 LAMP2 3920
Proximity Label-MS Homo sapiens
12 TNFAIP6 7130
Affinity Capture-MS Homo sapiens
13 ATN1  
Two-hybrid Homo sapiens
14 CTGF 1490
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 MTRF1  
Proximity Label-MS Homo sapiens
16 APP 351
Reconstituted Complex Homo sapiens
17 SULF2 55959
Affinity Capture-MS Homo sapiens
18 ZNF408  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 FAM150B  
Affinity Capture-MS Homo sapiens
20 LGALS1 3956
Affinity Capture-MS Homo sapiens
21 LECT2  
Affinity Capture-MS Homo sapiens
22 GCG  
Affinity Capture-MS Homo sapiens
23 FGF17  
Affinity Capture-MS Homo sapiens
24 LPL 4023
Reconstituted Complex Homo sapiens
25 SOST  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 DLG2 1740
Two-hybrid Homo sapiens
27 ARHGAP19  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 IGFL3  
Affinity Capture-MS Homo sapiens
29 DEFB125  
Affinity Capture-MS Homo sapiens
30 RAB35 11021
Proximity Label-MS Homo sapiens
31 APOH 350
Reconstituted Complex Homo sapiens
32 ANKRA2  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
33 WFDC1  
Affinity Capture-MS Homo sapiens
34 LAMTOR1 55004
Proximity Label-MS Homo sapiens
35 MAPK8IP2  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
36 SCN3A  
Two-hybrid Homo sapiens
37 RAB5A 5868
Proximity Label-MS Homo sapiens
38 MANSC1 54682
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 CLU 1191
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
40 RAB4A 5867
Proximity Label-MS Homo sapiens
41 MAPK8IP1 9479
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
42 ZBTB48  
Affinity Capture-MS Homo sapiens
43 FAM19A3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 SCGB1A1  
Reconstituted Complex Homo sapiens
45 ZFP41  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 SYNJ2BP 55333
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
47 B3GNT2 10678
Affinity Capture-MS Homo sapiens
48 ANAPC10  
Two-hybrid Homo sapiens
49 LDLRAP1 26119
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
50 THBS1 7057
Reconstituted Complex Homo sapiens
51 RAB7A 7879
Proximity Label-MS Homo sapiens
52 FEZF1  
Affinity Capture-MS Homo sapiens
53 FGFRL1 53834
Affinity Capture-MS Homo sapiens
54 MRPL11 65003
Proximity Label-MS Homo sapiens
55 INSL6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 UTP14C  
Affinity Capture-MS Homo sapiens
57 SEC61B 10952
Proximity Label-MS Homo sapiens
58 DKK2  
Affinity Capture-MS Homo sapiens
59 RNASE13  
Affinity Capture-MS Homo sapiens
60 CCDC59  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 MAP7 9053
Affinity Capture-MS Homo sapiens
62 MEPE  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 APOE 348
Reconstituted Complex Homo sapiens
64 APBA2 321
Two-hybrid Homo sapiens
65 RAB11A 8766
Proximity Label-MS Homo sapiens
66 LPA 4018
Reconstituted Complex Homo sapiens
67 ITGB1BP1 9270
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
68 CUL3 8452
Affinity Capture-MS Homo sapiens
69 STIM1 6786
Proximity Label-MS Homo sapiens
70 DLG4  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
71 ANKRD36B  
Affinity Capture-MS Homo sapiens
72 EMX2  
Affinity Capture-MS Homo sapiens
73 SEMG1 6406
Affinity Capture-MS Homo sapiens
74 SNX17 9784
Reconstituted Complex Homo sapiens
75 FBXO2 26232
Affinity Capture-MS Homo sapiens
76 RAB9A 9367
Proximity Label-MS Homo sapiens
77 TRIM33 51592
Affinity Capture-MS Homo sapiens
78 ACAD9 28976
Proximity Label-MS Homo sapiens
79 RIBC2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 OBP2A 29991
Affinity Capture-MS Homo sapiens
81 ZNF224  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 RBP1 5947
Reconstituted Complex Homo sapiens
83 ZC2HC1C  
Affinity Capture-MS Homo sapiens
84 IL20  
Affinity Capture-MS Homo sapiens
85 ANKS1B 56899
Two-hybrid Homo sapiens
86 NPTX1  
Affinity Capture-MS Homo sapiens
87 AMBN  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 GIPC1 10755
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
89 DAB2 1601
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
90 PDGFD 80310
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
91 VIP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 DLG3 1741
Two-hybrid Homo sapiens
93 ZNF264  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 MAGI1  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
95 LRP2BP  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
96 LRPAP1 4043
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
97 RAB2A 5862
Proximity Label-MS Homo sapiens
98 CALCA  
Affinity Capture-MS Homo sapiens
99 EGFL6 25975
Affinity Capture-MS Homo sapiens
100 SEC62 7095
Proximity Label-MS Homo sapiens
101 NTN5  
Affinity Capture-MS Homo sapiens
102 GLI4  
Affinity Capture-MS Homo sapiens
103 IL10 3586
Affinity Capture-MS Homo sapiens
104 ZNF517  
Affinity Capture-MS Homo sapiens
105 BRD1 23774
Affinity Capture-MS Homo sapiens
106 SNW1 22938
Affinity Capture-MS Homo sapiens
107 KRAS 3845
Proximity Label-MS Homo sapiens
108 RAB5C 5878
Proximity Label-MS Homo sapiens
109 CXCL16 58191
Affinity Capture-MS Homo sapiens
110 ALB 280717
Reconstituted Complex Bos taurus
111 PRSS23 11098
Affinity Capture-MS Homo sapiens
112 TIMP3 7078
Affinity Capture-MS Homo sapiens
113 FAM19A4  
Affinity Capture-MS Homo sapiens
114 PLAU 5328
Reconstituted Complex Homo sapiens
115 SYT1 6857
Affinity Capture-MS Homo sapiens
116 GREM2 64388
Affinity Capture-MS Homo sapiens
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