Gene description for SYT5
Gene name synaptotagmin V
Gene symbol SYT5
Other names/aliases -
Species Homo sapiens
 Database cross references - SYT5
ExoCarta ExoCarta_6861
Entrez Gene 6861
HGNC 11513
MIM 600782
UniProt O00445  
 SYT5 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for SYT5
Molecular Function
    protein heterodimerization activity GO:0046982 IEA
    calcium ion binding GO:0005509 IBA
    syntaxin binding GO:0019905 IBA
    clathrin binding GO:0030276 IBA
    calcium-dependent phospholipid binding GO:0005544 IBA
Biological Process
    synaptic vesicle exocytosis GO:0016079 IBA
    calcium ion-dependent exocytosis GO:0017156 IEA
    synaptic vesicle endocytosis GO:0048488 IBA
    regulation of calcium ion-dependent exocytosis GO:0017158 IBA
    energy reserve metabolic process GO:0006112 TAS
    regulation of insulin secretion GO:0050796 TAS
    synaptic transmission GO:0007268 TAS
    calcium ion-dependent exocytosis of neurotransmitter GO:0048791 IBA
    small molecule metabolic process GO:0044281 TAS
Subcellular Localization
    cell junction GO:0030054 IEA
    recycling endosome membrane GO:0055038 IEA
    perinuclear region of cytoplasm GO:0048471 IEA
    integral component of membrane GO:0016021 IEA
    neuronal cell body GO:0043025 IEA
    dense core granule GO:0031045 IEA
    neuron projection GO:0043005 IEA
    plasma membrane GO:0005886 IBA
    synaptic vesicle membrane GO:0030672 IBA
 Experiment description of studies that identified SYT5 in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for SYT5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SYT5 6861
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which SYT5 is involved
PathwayEvidenceSource
Regulation of insulin secretion TAS Reactome





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