Gene description for GRM2
Gene name	glutamate receptor, metabotropic 2
Gene symbol	GRM2
Other names/aliases	GLUR2 GPRC1B MGLUR2 mGlu2
Species	Homo sapiens
Database cross references - GRM2
ExoCarta	ExoCarta_2912
Vesiclepedia	VP_2912
Entrez Gene	2912
HGNC	4594
MIM	604099
UniProt	Q14416
GRM2 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells	Unpublished / Not applicable

Gene ontology annotations for GRM2

Molecular Function     group II metabotropic glutamate receptor activity GO:0001641 IBA     G protein-coupled receptor activity GO:0004930 TAS     calcium channel regulator activity GO:0005246 IEA     protein binding GO:0005515 IPI     glutamate receptor activity GO:0008066 TAS     scaffold protein binding GO:0097110 ISS Biological Process     negative regulation of adenylate cyclase activity GO:0007194 TAS     adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway GO:0007196 IEA     G protein-coupled glutamate receptor signaling pathway GO:0007216 IBA     chemical synaptic transmission GO:0007268 TAS     gene expression GO:0010467 IEA     glutamate secretion GO:0014047 IEA     regulation of glutamate secretion GO:0014048 IEA     regulation of dopamine secretion GO:0014059 IEA     cellular response to stress GO:0033554 IEA     behavioral response to nicotine GO:0035095 IEA     response to cocaine GO:0042220 IEA     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 ISS     regulation of synaptic transmission, glutamatergic GO:0051966 IBA     long-term synaptic depression GO:0060292 IEA     intracellular glutamate homeostasis GO:0090461 IEA     presynaptic modulation of chemical synaptic transmission GO:0099171 IEA     regulation of response to drug GO:2001023 IEA Subcellular Localization     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 TAS     axon GO:0030424 ISS     dendrite GO:0030425 IEA     presynaptic membrane GO:0042734 IEA     postsynaptic membrane GO:0045211 IEA     astrocyte projection GO:0097449 ISS     glutamatergic synapse GO:0098978 IEA