Gene description for SEL1L
Gene name sel-1 suppressor of lin-12-like (C. elegans)
Gene symbol SEL1L
Other names/aliases PRO1063
SEL1-LIKE
SEL1L1
Species Homo sapiens
 Database cross references - SEL1L
ExoCarta ExoCarta_6400
Vesiclepedia VP_6400
Entrez Gene 6400
HGNC 10717
MIM 602329
UniProt Q9UBV2  
 SEL1L identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Endothelial cells 26027894    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for SEL1L
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    triglyceride metabolic process GO:0006641 ISS
    Notch signaling pathway GO:0007219 IEA
    protein secretion GO:0009306 ISS
    retrograde protein transport, ER to cytosol GO:0030970 IMP
    ERAD pathway GO:0036503 IBA
    ERAD pathway GO:0036503 IMP
    ERAD pathway GO:0036503 ISS
    ERAD pathway GO:0036503 TAS
    protein stabilization GO:0050821 TAS
Subcellular Localization
    Hrd1p ubiquitin ligase complex GO:0000836 TAS
    Hrd1p ubiquitin ligase ERAD-L complex GO:0000839 IMP
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 IBA
    endoplasmic reticulum membrane GO:0005789 TAS
    Derlin-1 retrotranslocation complex GO:0036513 IDA
 Experiment description of studies that identified SEL1L in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 226
MISEV standards
EM
Biophysical techniques
GAPDH|CD9|FLOT1
Enriched markers
LMNA|H2AFX|ATP5A1|TOMM20
Negative markers
Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description "Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting"
Authors "Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar"
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
6
Experiment ID 834
MISEV standards
EM
Biophysical techniques
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 835
MISEV standards
EM
Biophysical techniques
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for SEL1L
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ITGB1 3688
Affinity Capture-Western Homo sapiens
2 KLRC3  
Affinity Capture-MS Homo sapiens
3 ERN1  
Affinity Capture-Western Homo sapiens
4 DERL2 51009
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
5 CD48 962
Affinity Capture-MS Homo sapiens
6 KLK5 25818
Affinity Capture-MS Homo sapiens
7 IGHM 3507
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
8 KLRK1  
Affinity Capture-MS Homo sapiens
9 KIF20A 10112
Affinity Capture-MS Homo sapiens
10 TRA  
Affinity Capture-Western Homo sapiens
11 IGFALS 3483
Affinity Capture-MS Homo sapiens
12 USP19 10869
Affinity Capture-Western Homo sapiens
13 TMEM5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 SYVN1 84447
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
15 HSPA5 3309
Affinity Capture-Western Homo sapiens
16 KIAA1429 25962
Affinity Capture-MS Homo sapiens
17 C9orf78 51759
Affinity Capture-MS Homo sapiens
18 TPSB2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 B3GNT2 10678
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 FAM8A1 51439
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
21 HEY1  
Affinity Capture-Western Homo sapiens
22 CLEC2B  
Affinity Capture-MS Homo sapiens
23 MRPL12 6182
Affinity Capture-MS Homo sapiens
24 CPA5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 TMEM129  
Affinity Capture-Western Homo sapiens
26 AMIGO3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 NXPH1  
Affinity Capture-MS Homo sapiens
28 PSG8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 SMPD1 6609
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 FAF2 23197
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
31 KIF14 9928
Affinity Capture-MS Homo sapiens
32 CHST12 55501
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 BSG 682
Affinity Capture-Western Homo sapiens
34 LRRC59 55379
Proximity Label-MS Homo sapiens
35 DPEP2  
Affinity Capture-MS Homo sapiens
36 FUT8 2530
Affinity Capture-MS Homo sapiens
37 LIPK  
Affinity Capture-MS Homo sapiens
38 AMFR 267
Affinity Capture-Western Homo sapiens
39 HSP90B1 7184
Affinity Capture-MS Homo sapiens
40 HEY2  
Affinity Capture-Western Homo sapiens
41 C12orf49  
Affinity Capture-MS Homo sapiens
42 IDS  
Affinity Capture-MS Homo sapiens
43 ACP5  
Affinity Capture-MS Homo sapiens
44 MYH9 4627
Co-fractionation Homo sapiens
45 SPAG11A  
Affinity Capture-MS Homo sapiens
46 NTRK1 4914
Affinity Capture-MS Homo sapiens
47 C1orf54  
Affinity Capture-MS Homo sapiens
48 PTPRE 5791
Affinity Capture-MS Homo sapiens
49 C4BPB 725
Affinity Capture-MS Homo sapiens
50 RPN1 6184
Affinity Capture-Western Homo sapiens
51 B4GALT3 8703
Affinity Capture-MS Homo sapiens
52 PTPRO 5800
Affinity Capture-MS Homo sapiens
53 SEC61B 10952
Proximity Label-MS Homo sapiens
54 ZPBP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 Edem1  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
56 DEFB121  
Affinity Capture-MS Homo sapiens
57 SYNJ2BP 55333
Co-fractionation Homo sapiens
58 NYX  
Affinity Capture-MS Homo sapiens
59 SARAF  
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
60 CALR3  
Proximity Label-MS Homo sapiens
61 C1QA 712
Affinity Capture-MS Homo sapiens
62 ERLEC1 27248
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
63 CBLN4  
Affinity Capture-MS Homo sapiens
64 EGFR 1956
Affinity Capture-MS Homo sapiens
65 LOC254896  
Affinity Capture-MS Homo sapiens
66 FBXO6 26270
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 AURKB 9212
Affinity Capture-MS Homo sapiens
68 CNR2  
Affinity Capture-MS Homo sapiens
69 ITGB4 3691
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
70 GXYLT1 283464
Affinity Capture-MS Homo sapiens
71 HYOU1 10525
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
72 DNASE1L1 1774
Affinity Capture-MS Homo sapiens
73 CHST8 64377
Affinity Capture-MS Homo sapiens
74 ISLR 3671
Affinity Capture-MS Homo sapiens
75 LPPR2  
Affinity Capture-MS Homo sapiens
76 FLOT1 10211
Co-fractionation Homo sapiens
77 UBE2J1 51465
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
78 LYZL2  
Affinity Capture-MS Homo sapiens
79 ITGA5 3678
Affinity Capture-Western Homo sapiens
80 FASN 2194
Negative Genetic Homo sapiens
81 NAAA  
Affinity Capture-MS Homo sapiens
82 UBXN4 23190
Affinity Capture-Western Homo sapiens
83 FOXRED2  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
84 TP53 7157
Affinity Capture-MS Homo sapiens
85 RPL6 6128
Two-hybrid Homo sapiens
86 HLA-DRA 3122
Affinity Capture-MS Homo sapiens
87 PDIA4 9601
Proximity Label-MS Homo sapiens
88 CALU 813
Proximity Label-MS Homo sapiens
89 ASIC4  
Affinity Capture-MS Homo sapiens
90 EDEM1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
91 UNC93B1 81622
Affinity Capture-MS Homo sapiens
92 OS9 10956
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
93 SLAMF1 6504
Affinity Capture-MS Homo sapiens
94 EDEM3 80267
Affinity Capture-Western Homo sapiens
95 EDEM2  
Affinity Capture-Western Homo sapiens
96 AUP1 550
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
97 SHH  
Affinity Capture-Western Homo sapiens
98 BRICD5  
Affinity Capture-MS Homo sapiens
99 METTL3  
Affinity Capture-MS Homo sapiens
100 GPHA2  
Affinity Capture-MS Homo sapiens
101 PLD6  
Affinity Capture-MS Homo sapiens
102 TRAV20  
Affinity Capture-MS Homo sapiens
103 TIMP3 7078
Affinity Capture-MS Homo sapiens
104 DERL1 79139
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml



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