Gene description for CMYA5
Gene name cardiomyopathy associated 5
Gene symbol CMYA5
Other names/aliases C5orf10
SPRYD2
TRIM76
Species Homo sapiens
 Database cross references - CMYA5
ExoCarta ExoCarta_202333
Vesiclepedia VP_202333
Entrez Gene 202333
HGNC 14305
MIM 612193
UniProt Q8N3K9  
 CMYA5 identified in sEVs derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for CMYA5
Subcellular Localization
    nucleus GO:0005634 ISS
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 IDA
    plasma membrane GO:0005886 IDA
    sarcoplasmic reticulum GO:0016529 ISS
    nuclear speck GO:0016607 IDA
    M band GO:0031430 IEA
    intracellular membrane-bounded organelle GO:0043231 IDA
    perinuclear region of cytoplasm GO:0048471 ISS
 Experiment description of studies that identified CMYA5 in sEVs
1
Experiment ID 224
MISEV standards
EM|AFM
Biophysical techniques
Alix|TSG101|CD63|CD81
Enriched markers
GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for CMYA5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HSPB2  
Two-hybrid Homo sapiens
2 PPME1 51400
Affinity Capture-MS Homo sapiens
3 ANLN 54443
Affinity Capture-MS Homo sapiens
4 AURKB 9212
Affinity Capture-MS Homo sapiens
5 VRK3 51231
Affinity Capture-MS Homo sapiens
6 CIT 11113
Affinity Capture-MS Homo sapiens
7 PSMC4 5704
Affinity Capture-MS Homo sapiens
8 KIF14 9928
Affinity Capture-MS Homo sapiens
9 PSMD14 10213
Affinity Capture-MS Homo sapiens
10 SIRT3  
Affinity Capture-MS Homo sapiens
11 MCM2 4171
Affinity Capture-MS Homo sapiens
12 FOXK1 221937
Co-fractionation Homo sapiens
13 EPRS 2058
Co-fractionation Homo sapiens
14 BZW1 9689
Affinity Capture-MS Homo sapiens
15 SIRT1  
Affinity Capture-MS Homo sapiens
16 ECT2 1894
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CMYA5 is involved
No pathways found





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