Gene description for FCHSD1
Gene name FCH and double SH3 domains 1
Gene symbol FCHSD1
Other names/aliases NWK2
Species Homo sapiens
 Database cross references - FCHSD1
ExoCarta ExoCarta_89848
Vesiclepedia VP_89848
Entrez Gene 89848
HGNC 25463
UniProt Q86WN1  
 FCHSD1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for FCHSD1
Molecular Function
    lipid binding GO:0008289 IEA
Biological Process
    neuromuscular synaptic transmission GO:0007274 IBA
    regulation of actin filament polymerization GO:0030833 IBA
    positive regulation of actin filament polymerization GO:0030838 ISS
    membrane organization GO:0061024 IEA
Subcellular Localization
    neuromuscular junction GO:0031594 IBA
    cuticular plate GO:0032437 ISS
    cell projection GO:0042995 IEA
    perikaryon GO:0043204 IEA
    recycling endosome GO:0055037 IBA
 Experiment description of studies that identified FCHSD1 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for FCHSD1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ASAP1 50807
Affinity Capture-MS Homo sapiens
2 SNX9 51429
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 XRCC6 2547
Affinity Capture-MS Homo sapiens
4 RNF115  
Affinity Capture-MS Homo sapiens
5 OR2A4 79541
Affinity Capture-MS Homo sapiens
6 MBNL1 4154
Affinity Capture-MS Homo sapiens
7 ITSN2 50618
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
8 SSUH2  
Affinity Capture-MS Homo sapiens
9 DNM2 1785
Affinity Capture-MS Homo sapiens
10 MOV10 4343
Affinity Capture-RNA Homo sapiens
11 CDK15  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 CCR1  
Affinity Capture-MS Homo sapiens
13 NCKIPSD 51517
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 STX17 55014
Affinity Capture-MS Homo sapiens
15 FCHSD1 89848
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
16 SBK1  
Affinity Capture-MS Homo sapiens
17 GOT1 2805
Affinity Capture-MS Homo sapiens
18 SNX33 257364
Affinity Capture-MS Homo sapiens
19 HSPA1A 3303
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which FCHSD1 is involved
No pathways found





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