Gene description for CNN1
Gene name calponin 1, basic, smooth muscle
Gene symbol CNN1
Other names/aliases HEL-S-14
Species Homo sapiens
 Database cross references - CNN1
ExoCarta ExoCarta_1264
Entrez Gene 1264
HGNC 2155
MIM 600806
UniProt P51911  
 CNN1 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for CNN1
Molecular Function
    calmodulin binding GO:0005516 IEA
    actin binding GO:0003779 IEA
Biological Process
    actomyosin structure organization GO:0031032 IEA
    regulation of smooth muscle contraction GO:0006940 TAS
Subcellular Localization
    cytoskeleton GO:0005856 IDA
    focal adhesion GO:0005925 IDA
 Experiment description of studies that identified CNN1 in exosomes
Experiment ID 224
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for CNN1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TPM1 7168
Reconstituted Complex Homo sapiens
2 ACTA1 58
Reconstituted Complex Homo sapiens
Invivo Homo sapiens
4 MYO1A 4640
Reconstituted Complex Homo sapiens
5 CALM1 801
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
6 TPM3 7170
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CNN1 is involved
No pathways found

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