Gene description for CPA4
Gene name carboxypeptidase A4
Gene symbol CPA4
Other names/aliases CPA3
Species Homo sapiens
 Database cross references - CPA4
ExoCarta ExoCarta_51200
Vesiclepedia VP_51200
Entrez Gene 51200
HGNC 15740
MIM 607635
UniProt Q9UI42  
 CPA4 identified in exosomes derived from the following tissue/cell type
Chondrocytes 35931686    
Chondrocytes 35931686    
 Gene ontology annotations for CPA4
Molecular Function
    metallocarboxypeptidase activity GO:0004181 IBA
    metallocarboxypeptidase activity GO:0004181 IDA
    metallocarboxypeptidase activity GO:0004181 NAS
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IEA
Biological Process
    proteolysis GO:0006508 IBA
    hormone catabolic process GO:0042447 IDA
    peptide catabolic process GO:0043171 IDA
Subcellular Localization
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 IDA
 Experiment description of studies that identified CPA4 in exosomes
1
Experiment ID 497
MISEV standards
Biophysical techniques
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 498
MISEV standards
EM
Biophysical techniques
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for CPA4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PRSS16 10279
Affinity Capture-MS Homo sapiens
2 ENDOG  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 ERCC3  
Affinity Capture-MS Homo sapiens
4 IFNA4  
Affinity Capture-MS Homo sapiens
5 RHBDD1 84236
Affinity Capture-MS Homo sapiens
6 KLHL11  
Affinity Capture-MS Homo sapiens
7 PPP2R2B 5521
Affinity Capture-MS Homo sapiens
8 SLC25A6 293
Affinity Capture-MS Homo sapiens
9 SEP15 9403
Affinity Capture-MS Homo sapiens
10 NDUFS5 4725
Affinity Capture-MS Homo sapiens
11 PIGT 51604
Affinity Capture-MS Homo sapiens
12 CCNC  
Affinity Capture-MS Homo sapiens
13 CD22 933
Affinity Capture-MS Homo sapiens
14 LXN 56925
Co-crystal Structure Homo sapiens
15 SLCO6A1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 NHLRC2 374354
Affinity Capture-MS Homo sapiens
17 ASCC1 51008
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 TCTN3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 TBC1D22B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 CPA2  
Affinity Capture-MS Homo sapiens
21 CDK15  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 PRG2  
Affinity Capture-MS Homo sapiens
23 PCP4  
Affinity Capture-MS Homo sapiens
24 ZSCAN12  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 RAB9B 51209
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 NPPA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 C1orf35  
Affinity Capture-MS Homo sapiens
28 OVOL2  
Affinity Capture-MS Homo sapiens
29 EBF2  
Affinity Capture-MS Homo sapiens
30 ZIC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 PTDSS1 9791
Affinity Capture-MS Homo sapiens
32 GSKIP  
Affinity Capture-MS Homo sapiens
33 PLK2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 FTH1 2495
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 PDPK1 5170
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 MYCBPAP 84073
Affinity Capture-MS Homo sapiens
37 ST6GALNAC6 30815
Affinity Capture-MS Homo sapiens
38 ADH1C 126
Affinity Capture-MS Homo sapiens
39 APTX  
Affinity Capture-MS Homo sapiens
40 C21orf59 56683
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 MOGAT3  
Affinity Capture-MS Homo sapiens
42 SH2D3A  
Affinity Capture-MS Homo sapiens
43 RPS19BP1  
Affinity Capture-MS Homo sapiens
44 MBNL1 4154
Affinity Capture-MS Homo sapiens
45 UBAC2 337867
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 KIR3DS1  
Affinity Capture-MS Homo sapiens
47 CCDC51 79714
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 SMAD9  
Affinity Capture-MS Homo sapiens
49 TEFM  
Affinity Capture-MS Homo sapiens
50 GALNT9  
Affinity Capture-MS Homo sapiens
51 AIRE  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 TSPAN6 7105
Affinity Capture-MS Homo sapiens
53 GPR18  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 GOT1 2805
Affinity Capture-MS Homo sapiens
55 SARAF  
Affinity Capture-MS Homo sapiens
56 E2F6 1876
Affinity Capture-MS Homo sapiens
57 POLR2L 5441
Affinity Capture-MS Homo sapiens
58 ST7  
Affinity Capture-MS Homo sapiens
59 OR2A4 79541
Affinity Capture-MS Homo sapiens
60 BEX5  
Affinity Capture-MS Homo sapiens
61 CTNNA1 1495
Co-fractionation Homo sapiens
62 GMCL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 GABPA 2551
Affinity Capture-MS Homo sapiens
64 CCR1  
Affinity Capture-MS Homo sapiens
65 ATP6AP2 10159
Affinity Capture-MS Homo sapiens
66 STX17 55014
Affinity Capture-MS Homo sapiens
67 B3GALNT1 8706
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 RIPPLY3  
Affinity Capture-MS Homo sapiens
69 CYLD  
Affinity Capture-MS Homo sapiens
70 POC5  
Affinity Capture-MS Homo sapiens
71 PHF8  
Affinity Capture-MS Homo sapiens
72 HTRA2 27429
Co-fractionation Homo sapiens
View the network image/svg+xml
 Pathways in which CPA4 is involved
No pathways found





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