Gene description for ITGB1BP1
Gene name integrin beta 1 binding protein 1
Gene symbol ITGB1BP1
Other names/aliases ICAP-1A
ICAP-1B
ICAP-1alpha
ICAP1
ICAP1A
ICAP1B
Species Homo sapiens
 Database cross references - ITGB1BP1
ExoCarta ExoCarta_9270
Vesiclepedia VP_9270
Entrez Gene 9270
HGNC 23927
MIM 607153
UniProt O14713  
 ITGB1BP1 identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for ITGB1BP1
Molecular Function
    GDP-dissociation inhibitor activity GO:0005092 IDA
    integrin binding GO:0005178 IBA
    integrin binding GO:0005178 IDA
    integrin binding GO:0005178 IPI
    protein binding GO:0005515 IPI
    protein kinase binding GO:0019901 IEA
Biological Process
    blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:0002043 IDA
    negative regulation of protein kinase activity GO:0006469 IDA
    negative regulation of cell adhesion involved in substrate-bound cell migration GO:0006933 ISS
    cell-matrix adhesion GO:0007160 IDA
    Notch signaling pathway GO:0007219 IEA
    integrin-mediated signaling pathway GO:0007229 IDA
    positive regulation of cell population proliferation GO:0008284 IDA
    negative regulation of cell population proliferation GO:0008285 IDA
    positive regulation of endothelial cell migration GO:0010595 IDA
    negative regulation of fibroblast migration GO:0010764 ISS
    cell migration GO:0016477 TAS
    cell differentiation GO:0030154 IEA
    biomineral tissue development GO:0031214 IEA
    negative regulation of protein binding GO:0032091 IDA
    activation of protein kinase B activity GO:0032148 IDA
    integrin activation GO:0033622 IDA
    integrin activation GO:0033622 ISS
    regulation of cell adhesion mediated by integrin GO:0033628 ISS
    tube formation GO:0035148 IDA
    intracellular signal transduction GO:0035556 TAS
    cellular response to vascular endothelial growth factor stimulus GO:0035924 IDA
    regulation of GTPase activity GO:0043087 IDA
    receptor clustering GO:0043113 ISS
    cellular response to fibroblast growth factor stimulus GO:0044344 IDA
    positive regulation of Notch signaling pathway GO:0045747 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    myoblast migration GO:0051451 ISS
    positive regulation of stress fiber assembly GO:0051496 ISS
    positive regulation of cell division GO:0051781 IEA
    positive regulation of focal adhesion assembly GO:0051894 IEA
    negative regulation of focal adhesion assembly GO:0051895 IBA
    negative regulation of focal adhesion assembly GO:0051895 IDA
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IDA
    negative regulation of ERK1 and ERK2 cascade GO:0070373 IDA
    protein localization to plasma membrane GO:0072659 IDA
    negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 IDA
    positive regulation of protein targeting to membrane GO:0090314 ISS
    negative regulation of protein targeting to membrane GO:0090315 IDA
    blood vessel diameter maintenance GO:0097746 IDA
    negative regulation of substrate adhesion-dependent cell spreading GO:1900025 IBA
    negative regulation of substrate adhesion-dependent cell spreading GO:1900025 IDA
    regulation of integrin-mediated signaling pathway GO:2001044 ISS
Subcellular Localization
    ruffle GO:0001726 IBA
    ruffle GO:0001726 IDA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
    cytoskeleton GO:0005856 IBA
    cytoskeleton GO:0005856 ISS
    plasma membrane GO:0005886 ISS
    focal adhesion GO:0005925 IDA
    membrane GO:0016020 NAS
    nuclear body GO:0016604 IDA
    lamellipodium GO:0030027 IBA
    lamellipodium GO:0030027 IDA
    centriolar satellite GO:0034451 IDA
    perinuclear region of cytoplasm GO:0048471 IDA
    cell periphery GO:0071944 IBA
    cell periphery GO:0071944 IDA
 Experiment description of studies that identified ITGB1BP1 in sEVs
1
Experiment ID 235
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
3
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for ITGB1BP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 APP 351
Reconstituted Complex Homo sapiens
2 ITGB1 3688
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
3 RHOH  
Two-hybrid Homo sapiens
4 LRP2 4036
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
5 SMO 6608
Two-hybrid Homo sapiens
6 LRP1 4035
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
7 FIGNL1 63979
Two-hybrid Homo sapiens
8 TANK 10010
Affinity Capture-Western Homo sapiens
9 SMURF2 64750
Reconstituted Complex Homo sapiens
10 SMURF1 57154
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
11 CCM2 83605
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 AURKA 6790
Affinity Capture-MS Homo sapiens
13 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
14 EEF1A1 1915
Two-hybrid Homo sapiens
15 MESDC1  
Affinity Capture-MS Homo sapiens
16 KRIT1 889
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
17 XPO1 7514
Affinity Capture-MS Homo sapiens
18 FAF1 11124
Two-hybrid Homo sapiens
19 CCDC33 80125
Two-hybrid Homo sapiens
20 LRP8 7804
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which ITGB1BP1 is involved
No pathways found





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