Gene description for LDLRAP1
Gene name low density lipoprotein receptor adaptor protein 1
Gene symbol LDLRAP1
Other names/aliases ARH
ARH1
ARH2
FHCB1
FHCB2
Species Homo sapiens
 Database cross references - LDLRAP1
ExoCarta ExoCarta_26119
Vesiclepedia VP_26119
Entrez Gene 26119
HGNC 18640
MIM 605747
UniProt Q5SW96  
 LDLRAP1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for LDLRAP1
Molecular Function
    amyloid-beta binding GO:0001540 IPI
    phosphotyrosine residue binding GO:0001784 IDA
    protein binding GO:0005515 IPI
    phosphatidylinositol-4,5-bisphosphate binding GO:0005546 IDA
    signaling receptor complex adaptor activity GO:0030159 IMP
    clathrin binding GO:0030276 IDA
    signaling adaptor activity GO:0035591 IDA
    AP-2 adaptor complex binding GO:0035612 IDA
    clathrin adaptor activity GO:0035615 IDA
    AP-1 adaptor complex binding GO:0035650 IDA
    low-density lipoprotein particle receptor binding GO:0050750 IPI
Biological Process
    receptor-mediated endocytosis GO:0006898 IDA
    cholesterol metabolic process GO:0008203 NAS
    cholesterol transport GO:0030301 NAS
    receptor internalization GO:0031623 IMP
    low-density lipoprotein particle clearance GO:0034383 IMP
    cholesterol homeostasis GO:0042632 IMP
    amyloid precursor protein metabolic process GO:0042982 IMP
    regulation of protein binding GO:0043393 IMP
    positive regulation of receptor-mediated endocytosis GO:0048260 IMP
    cellular response to cytokine stimulus GO:0071345 IMP
    receptor-mediated endocytosis involved in cholesterol transport GO:0090118 IMP
    positive regulation of cholesterol metabolic process GO:0090205 IC
    regulation of protein localization to plasma membrane GO:1903076 IMP
    positive regulation of vascular associated smooth muscle cell proliferation GO:1904707 IMP
    positive regulation of low-density lipoprotein particle clearance GO:1905581 IMP
    positive regulation of receptor-mediated endocytosis involved in cholesterol transport GO:1905602 IMP
Subcellular Localization
    early endosome GO:0005769 IBA
    early endosome GO:0005769 IDA
    cytosol GO:0005829 IDA
    neurofilament GO:0005883 ISS
    plasma membrane GO:0005886 TAS
    cytoplasmic side of plasma membrane GO:0009898 IDA
    basal plasma membrane GO:0009925 IDA
    axon GO:0030424 ISS
    clathrin-coated endocytic vesicle membrane GO:0030669 TAS
    recycling endosome GO:0055037 IDA
 Experiment description of studies that identified LDLRAP1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for LDLRAP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FASN 2194
Negative Genetic Homo sapiens
2 ZBTB2 57621
Affinity Capture-MS Homo sapiens
3 MAGEA4 4103
Two-hybrid Homo sapiens
4 NR0B2  
Affinity Capture-MS Homo sapiens
5 MAPK8IP3  
Two-hybrid Homo sapiens
6 KLC1 3831
Affinity Capture-Western Homo sapiens
7 DCAF16 54876
Affinity Capture-MS Homo sapiens
8 TMEM150A  
Affinity Capture-MS Homo sapiens
9 PSD4  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
10 HOXD8  
Two-hybrid Homo sapiens
11 PAX5  
Two-hybrid Homo sapiens
12 AP2B1 163
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
13 NLN 57486
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 OBFC1 79991
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
15 SREBF2 6721
Negative Genetic Homo sapiens
16 CCDC85C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 AHR 196
Affinity Capture-MS Homo sapiens
18 LRP2 4036
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
19 CHEK1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 LDLR 3949
Reconstituted Complex Homo sapiens
21 ESPNL  
Two-hybrid Homo sapiens
22 SNW1 22938
Affinity Capture-MS Homo sapiens
23 KLK13  
Affinity Capture-MS Homo sapiens
24 CLTC 1213
Reconstituted Complex Homo sapiens
25 FHL2 2274
Two-hybrid Homo sapiens
26 NOTO  
Two-hybrid Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here