Gene description for SLC13A2
Gene name solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
Gene symbol SLC13A2
Other names/aliases NADC1
NaCT
NaDC-1
SDCT1
Species Homo sapiens
 Database cross references - SLC13A2
ExoCarta ExoCarta_9058
Vesiclepedia VP_9058
Entrez Gene 9058
HGNC 10917
MIM 604148
UniProt Q13183  
 SLC13A2 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for SLC13A2
Molecular Function
    protein binding GO:0005515 IPI
    fumarate transmembrane transporter activity GO:0015138 IBA
    fumarate transmembrane transporter activity GO:0015138 IDA
    alpha-ketoglutarate transmembrane transporter activity GO:0015139 IBA
    alpha-ketoglutarate transmembrane transporter activity GO:0015139 IDA
    succinate transmembrane transporter activity GO:0015141 IBA
    succinate transmembrane transporter activity GO:0015141 IDA
    low-affinity sodium:dicarboxylate symporter activity GO:0015361 TAS
    sodium:dicarboxylate symporter activity GO:0017153 IBA
    sodium:dicarboxylate symporter activity GO:0017153 IDA
Biological Process
    fumarate transport GO:0015741 IBA
    fumarate transport GO:0015741 IDA
    alpha-ketoglutarate transport GO:0015742 IBA
    alpha-ketoglutarate transport GO:0015742 IDA
    sodium ion transmembrane transport GO:0035725 IEA
    cellular response to lithium ion GO:0071285 IBA
    cellular response to lithium ion GO:0071285 IDA
    succinate transmembrane transport GO:0071422 IBA
    succinate transmembrane transport GO:0071422 IDA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 TAS
    membrane GO:0016020 TAS
    apical plasma membrane GO:0016324 IDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified SLC13A2 in exosomes
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for SLC13A2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TRIM54  
Two-hybrid Homo sapiens
2 COL4A3BP 10087
Affinity Capture-MS Homo sapiens
3 PGK2 5232
Affinity Capture-MS Homo sapiens
4 TCEB3 6924
Affinity Capture-MS Homo sapiens
5 UBB 7314
Affinity Capture-MS Homo sapiens
6 UBA52 7311
Affinity Capture-MS Homo sapiens
7 TWISTNB  
Affinity Capture-MS Homo sapiens
8 SEC24D 9871
Affinity Capture-MS Homo sapiens
9 PCNXL3 399909
Affinity Capture-MS Homo sapiens
10 SARAF  
Affinity Capture-MS Homo sapiens
11 GDA 9615
Affinity Capture-MS Homo sapiens
12 SCAF4 57466
Affinity Capture-MS Homo sapiens
13 AMFR 267
Affinity Capture-MS Homo sapiens
14 ATG9A 79065
Affinity Capture-MS Homo sapiens
15 GAN 8139
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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