Gene description for SULT2B1
Gene name sulfotransferase family, cytosolic, 2B, member 1
Gene symbol SULT2B1
Other names/aliases HSST2
Species Homo sapiens
 Database cross references - SULT2B1
ExoCarta ExoCarta_6820
Vesiclepedia VP_6820
Entrez Gene 6820
HGNC 11459
MIM 604125
UniProt O00204  
 SULT2B1 identified in sEVs derived from the following tissue/cell type
Colorectal cancer cells 34887515    
 Gene ontology annotations for SULT2B1
Molecular Function
    nucleic acid binding GO:0003676 IMP
    protein binding GO:0005515 IPI
    sulfotransferase activity GO:0008146 IBA
    cholesterol binding GO:0015485 IDA
    small molecule binding GO:0036094 EXP
    steroid sulfotransferase activity GO:0050294 IDA
    cholesterol sulfotransferase activity GO:0051922 IEA
    steroid hormone binding GO:1990239 IMP
Biological Process
    steroid metabolic process GO:0008202 IDA
    cholesterol metabolic process GO:0008203 IMP
    negative regulation of cell population proliferation GO:0008285 IMP
    positive regulation of epidermal cell differentiation GO:0045606 IMP
    3'-phosphoadenosine 5'-phosphosulfate metabolic process GO:0050427 IDA
    sulfation GO:0051923 IBA
Subcellular Localization
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IBA
    endoplasmic reticulum GO:0005783 IEA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    intracellular membrane-bounded organelle GO:0043231 IDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified SULT2B1 in sEVs
1
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
 Protein-protein interactions for SULT2B1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FNDC5  
Affinity Capture-MS Homo sapiens
2 PRICKLE3  
Two-hybrid Homo sapiens
3 SULT1A2  
Affinity Capture-MS Homo sapiens
4 BPHL 670
Affinity Capture-MS Homo sapiens
5 NMT1 4836
Co-fractionation Homo sapiens
6 PLCB3 5331
Co-fractionation Homo sapiens
7 PPP2R2B 5521
Affinity Capture-MS Homo sapiens
8 AGPAT1 10554
Affinity Capture-MS Homo sapiens
9 SLC25A6 293
Affinity Capture-MS Homo sapiens
10 C18orf21  
Affinity Capture-MS Homo sapiens
11 CCNC  
Affinity Capture-MS Homo sapiens
12 FCF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 DDX19B 11269
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 SULT1A1 6817
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
15 SULT1C2 6819
Affinity Capture-MS Homo sapiens
16 SULT1E1 6783
Two-hybrid Homo sapiens
17 CCR1  
Affinity Capture-MS Homo sapiens
18 CDK15  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 C1orf35  
Affinity Capture-MS Homo sapiens
20 SSB 6741
Co-fractionation Homo sapiens
21 ZC3HC1  
Affinity Capture-MS Homo sapiens
22 ST6GALNAC6 30815
Affinity Capture-MS Homo sapiens
23 SSBP2  
Affinity Capture-MS Homo sapiens
24 CERS3  
Affinity Capture-MS Homo sapiens
25 KLHL11  
Affinity Capture-MS Homo sapiens
26 HEXA 3073
Co-fractionation Homo sapiens
27 RNF115  
Affinity Capture-MS Homo sapiens
28 SULT4A1  
Affinity Capture-MS Homo sapiens
29 SRRT 51593
Affinity Capture-MS Homo sapiens
30 SULT1A3 6818
Affinity Capture-MS Homo sapiens
31 MBNL1 4154
Affinity Capture-MS Homo sapiens
32 TBC1D22B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 ACYP2  
Two-hybrid Homo sapiens
34 PIGT 51604
Affinity Capture-MS Homo sapiens
35 PINK1  
Affinity Capture-MS Homo sapiens
36 GOT1 2805
Affinity Capture-MS Homo sapiens
37 TLN1 7094
Co-fractionation Homo sapiens
38 STK11 6794
Affinity Capture-MS Homo sapiens
39 SSUH2  
Affinity Capture-MS Homo sapiens
40 OR2A4 79541
Affinity Capture-MS Homo sapiens
41 MOCS3 27304
Co-fractionation Homo sapiens
42 HCN1  
Affinity Capture-MS Homo sapiens
43 GMCL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 UPK1A 11045
Affinity Capture-MS Homo sapiens
45 GABPA 2551
Affinity Capture-MS Homo sapiens
46 ALS2CR12  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
47 GUCY1A3  
Affinity Capture-MS Homo sapiens
48 NUDT5 11164
Co-fractionation Homo sapiens
49 STX17 55014
Affinity Capture-MS Homo sapiens
50 P2RX6  
Affinity Capture-MS Homo sapiens
51 RIPPLY3  
Affinity Capture-MS Homo sapiens
52 SULT2B1 6820
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
53 NSUN2 54888
Co-fractionation Homo sapiens
54 SULT1B1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
55 PHF11 51131
Affinity Capture-MS Homo sapiens
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