Gene description for MVD
Gene name mevalonate (diphospho) decarboxylase
Gene symbol MVD
Other names/aliases FP17780
MDDase
MPD
Species Homo sapiens
 Database cross references - MVD
ExoCarta ExoCarta_4597
Entrez Gene 4597
HGNC 7529
MIM 603236
UniProt P53602  
 MVD identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Squamous carcinoma cells 20124223    
 Gene ontology annotations for MVD
Molecular Function
    Hsp70 protein binding GO:0030544 IPI
    ATP binding GO:0005524 IEA
    protein homodimerization activity GO:0042803 IDA
    diphosphomevalonate decarboxylase activity GO:0004163 TAS
Biological Process
    small molecule metabolic process GO:0044281 TAS
    dolichyl diphosphate biosynthetic process GO:0006489 TAS
    protein N-linked glycosylation via asparagine GO:0018279 TAS
    post-translational protein modification GO:0043687 TAS
    positive regulation of cell proliferation GO:0008284 IMP
    isopentenyl diphosphate biosynthetic process, mevalonate pathway GO:0019287 IEA
    dolichol-linked oligosaccharide biosynthetic process GO:0006488 TAS
    cholesterol biosynthetic process GO:0006695 TAS
    cellular protein metabolic process GO:0044267 TAS
    isoprenoid biosynthetic process GO:0008299 IDA
Subcellular Localization
    cytosol GO:0005829 TAS
    peroxisome GO:0005777 IDA
 Experiment description of studies that identified MVD in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 191
ISEV standards
✘ EV Biophysical techniques
✔
Alix
EV Cytosolic markers
✔
CD81|CD9
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MVD
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HSPA9 3313
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
2 MVD 4597
Invitro Homo sapiens
Invitro Homo sapiens
3 BTAF1 9044
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
4 EEF1G 1937
Two-hybrid Homo sapiens
5 GNB5 10681
Two-hybrid Homo sapiens
View the network image/svg+xml



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