Gene description for BTG2
Gene name BTG family, member 2
Gene symbol BTG2
Other names/aliases PC3
Species Homo sapiens
 Database cross references - BTG2
ExoCarta ExoCarta_7832
Entrez Gene 7832
HGNC 1131
MIM 601597
UniProt P78543  
 BTG2 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for BTG2
Molecular Function
    protein binding GO:0005515 IPI
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001077 IEA
Biological Process
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IEA
    transcription, DNA-templated GO:0006351 IEA
    negative regulation of cell proliferation GO:0008285 IMP
    response to mechanical stimulus GO:0009612 IEA
    positive regulation of nuclear-transcribed mRNA poly(A) tail shortening GO:0060213 IDA
    protein methylation GO:0006479 IEA
    negative regulation of translation GO:0017148 IDA
    central nervous system neuron development GO:0021954 IEA
    negative regulation of neural precursor cell proliferation GO:2000178 IEA
    response to electrical stimulus GO:0051602 IEA
    DNA repair GO:0006281 TAS
    anterior/posterior pattern specification GO:0009952 IEA
    neuron projection development GO:0031175 IMP
    negative regulation of neuron apoptotic process GO:0043524 IEA
    dentate gyrus development GO:0021542 IEA
    skeletal muscle cell differentiation GO:0035914 IEA
    response to organic cyclic compound GO:0014070 IEA
    associative learning GO:0008306 IEA
    response to peptide hormone GO:0043434 IEA
    cellular response to DNA damage stimulus GO:0006974 IDA
Subcellular Localization
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified BTG2 in exosomes
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for BTG2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CNOT7 29883
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
2 CNOT6L  
Affinity Capture-MS Homo sapiens
3 PKC  
Biochemical Activity Homo sapiens
4 HOXB9  
Two-hybrid Homo sapiens
Far Western Homo sapiens
5 CNOT1 23019
Affinity Capture-MS Homo sapiens
6 PRMT1 3276
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Co-purification Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
7 CNOT8  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
8 Prkcabp  
Reconstituted Complex Rattus norvegicus
Affinity Capture-Western Rattus norvegicus
Two-hybrid Rattus norvegicus
9 HOXC8  
Far Western Homo sapiens
View the network image/svg+xml
 Pathways in which BTG2 is involved
No pathways found

Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here