Gene description for SQSTM1
Gene name	sequestosome 1
Gene symbol	SQSTM1
Other names/aliases	A170 OSIL PDB3 ZIP3 p60 p62 p62B
Species	Homo sapiens
Database cross references - SQSTM1
ExoCarta	ExoCarta_8878
Vesiclepedia	VP_8878
Entrez Gene	8878
HGNC	11280
MIM	601530
UniProt	Q13501
SQSTM1 identified in sEVs derived from the following tissue/cell type
Bladder cancer cells	20224111
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Breast cancer cells	34108659
Breast cancer cells	34108659
Breast cancer cells	34108659
Breast cancer cells	34108659
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Embryonic kidney cells	34108659
Embryonic kidney cells	34108659
Embryonic kidney cells	34108659
Foreskin fibroblasts	34108659
Gastric cancer cells	33991177
Gastric cancer cells	33991177
Gastric cancer cells	33991177
Hepatocellular carcinoma cells	26054723
Hepatocellular carcinoma cells	26054723
Hepatocytes	26054723
Lymphoma cells	34108659
Mammary cancer-associated fibroblasts	34108659
Melanoma cells	22635005
Melanoma cells	25950383
Melanoma cells	25950383
Mesenchymal stem cells	36408942
Monocytic leukemia cells	34108659
Normal mammary epithelial cells	34108659
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927
Pancreatic cancer cells	34108659
Pancreatic cancer cells	34108659
Pancreatic cancer cells	34108659
Pancreatic cancer cells	34108659
Pancreatic duct epithalial cells	34108659
Pancreatic duct epithalial cells	34108659
Pluripotent stem cells	34108659
Prostate cancer cells	25844599
Squamous carcinoma cells	20124223
T lymphocytes	34108659
Thymus	23844026
Urine	19056867

Gene ontology annotations for SQSTM1

Molecular Function     protein kinase C binding GO:0005080 IBA     protein kinase C binding GO:0005080 IPI     protein binding GO:0005515 IPI     zinc ion binding GO:0008270 IEA     enzyme binding GO:0019899 IPI     protein kinase binding GO:0019901 IDA     protein-macromolecule adaptor activity GO:0030674 IDA     receptor tyrosine kinase binding GO:0030971 TAS     ubiquitin protein ligase binding GO:0031625 IDA     ubiquitin protein ligase binding GO:0031625 IPI     ionotropic glutamate receptor binding GO:0035255 ISS     signaling receptor activity GO:0038023 IDA     SH2 domain binding GO:0042169 IDA     identical protein binding GO:0042802 IPI     ubiquitin binding GO:0043130 IDA     ubiquitin binding GO:0043130 TAS     protein-containing complex binding GO:0044877 IEA     K63-linked polyubiquitin modification-dependent protein binding GO:0070530 IBA     K63-linked polyubiquitin modification-dependent protein binding GO:0070530 IDA     ubiquitin-modified protein reader activity GO:0140036 IDA     protein sequestering activity GO:0140311 IDA     molecular sequestering activity GO:0140313 IDA     molecular condensate scaffold activity GO:0140693 IDA Biological Process     negative regulation of transcription by RNA polymerase II GO:0000122 IEA     autophagy of mitochondrion GO:0000422 NAS     mitophagy GO:0000423 IBA     mitophagy GO:0000423 IGI     pexophagy GO:0000425 IDA     temperature homeostasis GO:0001659 IEA     immune system process GO:0002376 IEA     response to ischemia GO:0002931 IEA     transcription by RNA polymerase II GO:0006366 IEA     ubiquitin-dependent protein catabolic process GO:0006511 TAS     protein import into nucleus GO:0006606 IEA     autophagy GO:0006914 IDA     autophagy GO:0006914 IMP     autophagy GO:0006914 TAS     apoptotic process GO:0006915 IEA     endosome organization GO:0007032 IBA     endosome organization GO:0007032 IDA     protein localization GO:0008104 TAS     positive regulation of autophagy GO:0010508 IDA     regulation of mitochondrion organization GO:0010821 NAS     endosomal transport GO:0016197 TAS     macroautophagy GO:0016236 IMP     macroautophagy GO:0016236 ISS     cell differentiation GO:0030154 IEA     protein catabolic process GO:0030163 IDA     negative regulation of protein ubiquitination GO:0031397 IDA     cellular response to stress GO:0033554 IDA     negative regulation of toll-like receptor 4 signaling pathway GO:0034144 IDA     intracellular signal transduction GO:0035556 TAS     aggrephagy GO:0035973 IBA     aggrephagy GO:0035973 IDA     aggrephagy GO:0035973 IPI     positive regulation of apoptotic process GO:0043065 TAS     regulation of canonical NF-kappaB signal transduction GO:0043122 IMP     positive regulation of transcription by RNA polymerase II GO:0045944 TAS     regulation of Ras protein signal transduction GO:0046578 NAS     regulation of protein complex stability GO:0061635 IDA     brown fat cell proliferation GO:0070342 IEA     protein targeting to vacuole involved in autophagy GO:0071211 IDA     energy homeostasis GO:0097009 IEA     response to mitochondrial depolarisation GO:0098780 IGI     negative regulation of ferroptosis GO:0110076 IMP     membraneless organelle assembly GO:0140694 IDA     positive regulation of long-term synaptic potentiation GO:1900273 ISS     positive regulation of protein localization to plasma membrane GO:1903078 ISS     protein localization to perinuclear region of cytoplasm GO:1905719 IDA Subcellular Localization     phagophore assembly site GO:0000407 IEA     P-body GO:0000932 IDA     nucleoplasm GO:0005654 TAS     cytoplasm GO:0005737 IC     cytoplasm GO:0005737 IDA     mitochondrion GO:0005739 IEA     late endosome GO:0005770 IEA     autophagosome GO:0005776 IDA     autophagosome GO:0005776 IDA     endoplasmic reticulum GO:0005783 IEA     cytosol GO:0005829 IDA     cytosol GO:0005829 IDA     cytosol GO:0005829 TAS     inclusion body GO:0016234 IDA     aggresome GO:0016235 IBA     PML body GO:0016605 IDA     sarcomere GO:0030017 IEA     intracellular membrane-bounded organelle GO:0043231 IDA     intracellular membraneless organelle GO:0043232 IDA     amphisome GO:0044753 IBA     amphisome GO:0044753 IDA     autolysosome GO:0044754 IDA     extracellular exosome GO:0070062 HDA     sperm midpiece GO:0097225 IEA     Lewy body GO:0097413 IEA     glutamatergic synapse GO:0098978 IEA