Gene description for UBE2D2
Gene name ubiquitin-conjugating enzyme E2D 2
Gene symbol UBE2D2
Other names/aliases E2(17)KB2
PUBC1
UBC4
UBC4/5
UBCH4
UBCH5B
Species Homo sapiens
 Database cross references - UBE2D2
ExoCarta ExoCarta_7322
Vesiclepedia VP_7322
Entrez Gene 7322
HGNC 12475
MIM 602962
UniProt P62837  
 UBE2D2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Chondrocytes 35931686    
Chondrocytes 35931686    
Mesenchymal stem cells 36408942    
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
Prostate cancer cells 25844599    
 Gene ontology annotations for UBE2D2
Molecular Function
    ubiquitin-protein transferase activity GO:0004842 IDA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    ubiquitin protein ligase activity GO:0061630 IDA
    ubiquitin conjugating enzyme activity GO:0061631 IBA
    ubiquitin conjugating enzyme activity GO:0061631 IDA
Biological Process
    protein polyubiquitination GO:0000209 IDA
    ubiquitin-dependent protein catabolic process GO:0006511 IBA
    protein ubiquitination GO:0016567 IDA
    protein modification process GO:0036211 TAS
    protein autoubiquitination GO:0051865 IDA
    protein K48-linked ubiquitination GO:0070936 IBA
    protein K48-linked ubiquitination GO:0070936 IDA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleoplasm GO:0005654 TAS
    cytosol GO:0005829 TAS
    protein-containing complex GO:0032991 IDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified UBE2D2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 498
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
8
Experiment ID 231
MISEV standards
✘ Biophysical techniques
✔
Alix|CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
9
Experiment ID 232
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
10
Experiment ID 233
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
11
Experiment ID 274
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
 Protein-protein interactions for UBE2D2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SIAH1  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
2 TRAIP  
Reconstituted Complex Homo sapiens
3 UBE2H 7328
Affinity Capture-MS Homo sapiens
4 MIB1 57534
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
5 MAFF 23764
Affinity Capture-MS Homo sapiens
6 XIAP  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
7 RNF122  
Reconstituted Complex Homo sapiens
8 UBE2M 9040
Co-fractionation Homo sapiens
9 FBXO7 25793
Biochemical Activity Homo sapiens
10 SIAH2 6478
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
11 TRIM3 10612
Reconstituted Complex Homo sapiens
12 WWP1 11059
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
13 NFKB1 4790
Biochemical Activity Homo sapiens
14 NKD2 85409
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 MARCH7  
Reconstituted Complex Homo sapiens
16 TRIM35 23087
Two-hybrid Homo sapiens
17 VPRBP 9730
Reconstituted Complex Homo sapiens
18 TRIM2  
Two-hybrid Homo sapiens
19 RNF25 64320
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 MKRN3  
Two-hybrid Homo sapiens
21 UBA1 7317
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
22 BRCA1 672
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
23 EPS15 2060
Biochemical Activity Homo sapiens
24 UBE3A 7337
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
25 USP9X 8239
Co-fractionation Homo sapiens
26 UBC 7316
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Co-crystal Structure Homo sapiens
Co-crystal Structure Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
27 CHFR  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
28 VHL  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
29 TRIM55  
Two-hybrid Homo sapiens
30 FCGR2A 2212
Affinity Capture-MS Homo sapiens
31 MID1 4281
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
32 DVL3 1857
Affinity Capture-MS Homo sapiens
33 SYVN1 84447
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
34 LTN1 26046
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
35 RNF216  
Reconstituted Complex Homo sapiens
36 CCDC58 131076
Co-fractionation Homo sapiens
37 RFFL 117584
Reconstituted Complex Homo sapiens
38 RCHY1  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
39 DUSP14 11072
Affinity Capture-MS Homo sapiens
40 ARL6IP6  
Affinity Capture-MS Homo sapiens
41 PJA1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
42 TRIM28 10155
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
43 UFM1 51569
Two-hybrid Homo sapiens
44 RNF5  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
45 PELI1 57162
Reconstituted Complex Homo sapiens
46 UBE2L3 7332
Co-fractionation Homo sapiens
47 MCM2 4171
Affinity Capture-MS Homo sapiens
48 UBE2K 3093
Co-fractionation Homo sapiens
49 MYLIP  
Reconstituted Complex Homo sapiens
50 RNF8  
Two-hybrid Homo sapiens
51 TRIM34  
Reconstituted Complex Homo sapiens
52 POLM  
Biochemical Activity Homo sapiens
53 TRIM50  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
54 RNF19A  
Reconstituted Complex Homo sapiens
55 POLL  
Biochemical Activity Homo sapiens
56 HERC4 26091
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
57 MARCH5  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
58 DDX58 23586
Biochemical Activity Homo sapiens
59 UBQLN1 29979
Co-fractionation Homo sapiens
60 ANAPC11  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
61 MID2 11043
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
62 LRSAM1 90678
Two-hybrid Homo sapiens
63 HERC2 8924
Reconstituted Complex Homo sapiens
64 TRIM26 7726
Two-hybrid Homo sapiens
65 TMEM192 201931
Affinity Capture-MS Homo sapiens
66 BIRC3 330
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
67 AASDHPPT 60496
Co-fractionation Homo sapiens
68 TIAL1 7073
Co-fractionation Homo sapiens
69 UBE2F  
Co-fractionation Homo sapiens
70 RNF126  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
71 AAK1 22848
Affinity Capture-MS Homo sapiens
72 CBLB 868
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
73 RNF114 55905
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
74 RNF123 63891
Reconstituted Complex Homo sapiens
75 RNF167 26001
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
76 NEDD4 4734
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
77 RNF26  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
78 BFAR  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
79 RNF11 26994
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
80 RNF115  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
81 TRIM8  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
82 UBE2V1 7335
Co-fractionation Homo sapiens
83 UBR4 23352
Reconstituted Complex Homo sapiens
84 TRIM41 90933
Reconstituted Complex Homo sapiens
85 STAM2 10254
Biochemical Activity Homo sapiens
86 THAP8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 HECW1  
Reconstituted Complex Homo sapiens
88 RNF144A  
Biochemical Activity Homo sapiens
89 RNF165  
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Co-crystal Structure Homo sapiens
Two-hybrid Homo sapiens
90 ING4  
Affinity Capture-MS Homo sapiens
91 UBE4B 10277
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
92 RNF4 6047
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
93 TRIM7  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
94 RNF213 57674
Reconstituted Complex Homo sapiens
95 RBX1 9978
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
96 RNF185  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
97 LUZP1 7798
Affinity Capture-MS Homo sapiens
98 PARK2  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
99 CADPS2  
Two-hybrid Homo sapiens
100 AMFR 267
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
101 PDZRN3 23024
Reconstituted Complex Homo sapiens
102 DTX1  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
103 MEX3C 51320
Reconstituted Complex Homo sapiens
104 TRIM65 201292
Reconstituted Complex Homo sapiens
105 CBL 867
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
106 CNOT4 4850
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
107 RNF146  
Biochemical Activity Homo sapiens
108 SOCS6  
Reconstituted Complex Homo sapiens
109 ZNRF2 223082
Two-hybrid Homo sapiens
110 UBE2I 7329
Co-fractionation Homo sapiens
111 TRIM54  
Two-hybrid Homo sapiens
112 UBASH3B 84959
Biochemical Activity Homo sapiens
113 UBR5 51366
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
114 CCNB1 891
Biochemical Activity Homo sapiens
115 MYCBP2 23077
Reconstituted Complex Homo sapiens
116 UBB 7314
Reconstituted Complex Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
117 PMAIP1  
Reconstituted Complex Homo sapiens
118 RAG1  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
119 TRIM21 6737
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
120 RNF166  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
121 RNF224  
Reconstituted Complex Homo sapiens
122 RAD18  
Reconstituted Complex Homo sapiens
123 HACE1 57531
Reconstituted Complex Homo sapiens
124 F12  
Reconstituted Complex Homo sapiens
125 TRIM32 22954
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
126 TRIM11  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
127 VPS11 55823
Reconstituted Complex Homo sapiens
128 CSNK1E 1454
Affinity Capture-MS Homo sapiens
129 RNF13 11342
Two-hybrid Homo sapiens
130 UBE2D3 7323
Cross-Linking-MS (XL-MS) Homo sapiens
131 HECTD1 25831
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
132 BARD1 580
Reconstituted Complex Homo sapiens
133 UBA3 9039
Reconstituted Complex Homo sapiens
134 RNF125  
Two-hybrid Homo sapiens
135 TRIM17  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
136 RNF186  
Two-hybrid Homo sapiens
137 ITCH 83737
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
138 VPS18 57617
Reconstituted Complex Homo sapiens
139 QSER1  
Affinity Capture-MS Homo sapiens
140 TRIM63  
Reconstituted Complex Homo sapiens
141 TRIM43  
Two-hybrid Homo sapiens
142 TRIM23 373
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
143 UBR2 23304
Reconstituted Complex Homo sapiens
144 ZPR1 8882
Co-fractionation Homo sapiens
145 FBXO4 26272
Biochemical Activity Homo sapiens
146 RNF168  
Reconstituted Complex Homo sapiens
147 RING1 6015
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
148 BIRC2  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
149 MARCH3 115123
Two-hybrid Homo sapiens
150 RNF40 9810
Reconstituted Complex Homo sapiens
151 MAPT  
Biochemical Activity Homo sapiens
152 TRIM46 80128
Reconstituted Complex Homo sapiens
153 RNF219  
Reconstituted Complex Homo sapiens
154 QSOX1 5768
Biochemical Activity Homo sapiens
155 RNF34  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
156 CUL3 8452
Reconstituted Complex Homo sapiens
157 AHCYL1 10768
Co-fractionation Homo sapiens
158 RNF181  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
159 TRIM33 51592
Reconstituted Complex Homo sapiens
160 RC3H2  
Reconstituted Complex Homo sapiens
161 RNF170 81790
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
162 RELA 5970
Biochemical Activity Homo sapiens
163 UBXN7 26043
Co-fractionation Homo sapiens
164 TRIM10  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
165 RNF14 9604
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
166 NAT10 55226
Reconstituted Complex Homo sapiens
167 RLIM 51132
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Two-hybrid Homo sapiens
168 NFKBIA  
Biochemical Activity Homo sapiens
169 KCMF1 56888
Reconstituted Complex Homo sapiens
170 RNF130  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
171 RNF150  
Two-hybrid Homo sapiens
172 TAX1BP3 30851
Co-fractionation Homo sapiens
173 TRAF6 7189
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
174 MTAP 4507
Co-fractionation Homo sapiens
175 TTC3 7267
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
176 UHRF2  
Two-hybrid Homo sapiens
177 Rbx1  
Reconstituted Complex Mus musculus
178 MAP3K1 4214
Two-hybrid Homo sapiens
179 RNF19B  
Reconstituted Complex Homo sapiens
180 MDM4  
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
181 HIP1R 9026
Affinity Capture-MS Homo sapiens
182 UBE2R2 54926
Co-fractionation Homo sapiens
183 OR5F1  
Affinity Capture-MS Homo sapiens
184 BTRC 8945
Biochemical Activity Homo sapiens
185 RNF138  
Two-hybrid Homo sapiens
186 MGRN1 23295
Two-hybrid Homo sapiens
187 ARIH2 10425
Two-hybrid Homo sapiens
188 UBE2D2 7322
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
189 TRIM62  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
190 HSP90AA4P 3323
Co-fractionation Homo sapiens
191 UBR1 197131
Reconstituted Complex Homo sapiens
192 RNF220  
Reconstituted Complex Homo sapiens
193 RNF103  
Two-hybrid Homo sapiens
194 HECW2  
Reconstituted Complex Homo sapiens
195 PPIP5K2 23262
Affinity Capture-MS Homo sapiens
196 FBXO2 26232
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
197 SELENBP1 8991
Affinity Capture-MS Homo sapiens
198 ARRDC3 57561
Two-hybrid Homo sapiens
199 RNF151  
Reconstituted Complex Homo sapiens
200 TRIM27  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
201 TRAF2 7186
Reconstituted Complex Homo sapiens
202 UBTD1 80019
Two-hybrid Homo sapiens
Co-purification Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
203 RAF1 5894
Biochemical Activity Homo sapiens
204 RFWD3  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
205 RNF2  
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
206 BMI1  
Reconstituted Complex Homo sapiens
207 Nedd4 17999
Reconstituted Complex Mus musculus
208 CCDC88A 55704
Affinity Capture-MS Homo sapiens
209 NFYA 4800
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
210 CDKN1B 1027
Biochemical Activity Homo sapiens
211 TRIM39  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
212 RNF149 284996
Reconstituted Complex Homo sapiens
213 MDM2  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
214 NEDD4L 23327
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
215 MARCH6  
Reconstituted Complex Homo sapiens
216 HUWE1 10075
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
217 UBE2D1 7321
Co-fractionation Homo sapiens
218 CBLC  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
219 STUB1 10273
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Co-purification Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
220 SEC24B 10427
Affinity Capture-MS Homo sapiens
221 DZIP3  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
222 TRIM5 85363
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
223 TRAF7  
Two-hybrid Homo sapiens
224 RNF43  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
225 TRIM38 10475
Two-hybrid Homo sapiens
226 FBXW2  
Biochemical Activity Homo sapiens
227 SMURF2 64750
Reconstituted Complex Homo sapiens
228 AREL1  
Reconstituted Complex Homo sapiens
229 LNX2  
Reconstituted Complex Homo sapiens
230 MUL1  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
231 SPOP  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
232 TRIM13  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
233 TTC1 7265
Co-fractionation Homo sapiens
234 PLEC 5339
Affinity Capture-MS Homo sapiens
235 DTX3L 151636
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
236 SPRY2 10253
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
237 NSMCE1  
Reconstituted Complex Homo sapiens
238 RNF135  
Reconstituted Complex Homo sapiens
239 TP53 7157
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
240 UBA5 79876
Reconstituted Complex Homo sapiens
241 TRIM45  
Two-hybrid Homo sapiens
242 BIRC8  
Two-hybrid Homo sapiens
243 RFWD2  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
244 HECTD4 283450
Reconstituted Complex Homo sapiens
245 HECTD3 79654
Reconstituted Complex Homo sapiens
246 RNF10  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
247 RNF31 55072
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
248 BRAP  
Reconstituted Complex Homo sapiens
249 RSPRY1 89970
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
250 RMND5B  
Two-hybrid Homo sapiens
251 SMURF1 57154
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
252 SQSTM1 8878
Proximity Label-MS Homo sapiens
253 ZNRF1  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
254 FSD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
255 UBE4A 9354
Two-hybrid Homo sapiens
256 PJA2  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
257 UBR3  
Reconstituted Complex Homo sapiens
258 RNF20 56254
Reconstituted Complex Homo sapiens
259 OTUB1 55611
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
260 UBOX5  
Two-hybrid Homo sapiens
261 UBD  
Reconstituted Complex Homo sapiens
262 TRIM25 7706
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
263 RNF7  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
264 UBE3C 9690
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
265 TRIP12 9320
Reconstituted Complex Homo sapiens
266 ANAPC2 29882
Reconstituted Complex Homo sapiens
267 FBXL3  
Biochemical Activity Homo sapiens
268 WWP2 11060
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
269 TXN 7295
Co-fractionation Homo sapiens
270 RNF38  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
271 TRIM37  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
272 EYA4 2070
Affinity Capture-MS Homo sapiens
273 ACOX1 51
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
274 TRIM36  
Reconstituted Complex Homo sapiens
275 WSB1 26118
Reconstituted Complex Homo sapiens
276 ZNRF4  
Two-hybrid Homo sapiens
277 TRIM31  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
278 SSSCA1 10534
Co-fractionation Homo sapiens
279 RNF111 54778
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
280 Nedd4l 83814
Reconstituted Complex Mus musculus
281 HERC1 8925
Reconstituted Complex Homo sapiens
282 STK11 6794
Biochemical Activity Homo sapiens
283 TOPORS  
Two-hybrid Homo sapiens
284 RDH12 145226
Affinity Capture-MS Homo sapiens
285 MIB2 142678
Reconstituted Complex Homo sapiens
286 DTX3  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
287 HERC5 51191
Reconstituted Complex Homo sapiens
288 MEX3A  
Reconstituted Complex Homo sapiens
289 BIRC7  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
290 RC3H1 149041
Reconstituted Complex Homo sapiens
291 UBA6 55236
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
292 CUEDC1 404093
Two-hybrid Homo sapiens
293 PHRF1  
Reconstituted Complex Homo sapiens
294 RBCK1  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
295 Rnf115  
Reconstituted Complex Mus musculus
296 RTFDC1  
Reconstituted Complex Homo sapiens
297 LNX1  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
298 NEDD8 4738
Co-crystal Structure Homo sapiens
299 Rag1  
Reconstituted Complex Mus musculus
View the network image/svg+xml
 Pathways in which UBE2D2 is involved
PathwayEvidenceSource
Adaptive Immune System TAS Reactome
Antigen processing: Ubiquitination & Proteasome degradation TAS Reactome
Autophagy TAS Reactome
C-type lectin receptors (CLRs) TAS Reactome
Cellular response to hypoxia TAS Reactome
Cellular responses to stimuli TAS Reactome
Cellular responses to stress TAS Reactome
Class I MHC mediated antigen processing & presentation TAS Reactome
CLEC7A (Dectin-1) signaling TAS Reactome
Cytokine Signaling in Immune system TAS Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta IEA Reactome
Death Receptor Signaling TAS Reactome
Downstream TCR signaling TAS Reactome
E3 ubiquitin ligases ubiquitinate target proteins TAS Reactome
Fc epsilon receptor (FCERI) signaling TAS Reactome
FCERI mediated NF-kB activation TAS Reactome
IKK complex recruitment mediated by RIP1 TAS Reactome
Immune System TAS Reactome
Immune System IEA Reactome
Inactivation of CSF3 (G-CSF) signaling TAS Reactome
Innate Immune System IEA Reactome
Innate Immune System TAS Reactome
Macroautophagy TAS Reactome
Metabolism of proteins TAS Reactome
Mitophagy TAS Reactome
MyD88-independent TLR4 cascade TAS Reactome
Neddylation TAS Reactome
Negative regulators of DDX58/IFIH1 signaling IEA Reactome
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha TAS Reactome
Peroxisomal protein import TAS Reactome
PINK1-PRKN Mediated Mitophagy TAS Reactome
Post-translational protein modification TAS Reactome
Protein localization TAS Reactome
Protein ubiquitination TAS Reactome
Regulation of TNFR1 signaling TAS Reactome
Selective autophagy TAS Reactome
Signal Transduction TAS Reactome
Signaling by CSF3 (G-CSF) TAS Reactome
Synthesis of active ubiquitin: roles of E1 and E2 enzymes TAS Reactome
TCR signaling TAS Reactome
TICAM1, RIP1-mediated IKK complex recruitment TAS Reactome
TNF signaling TAS Reactome
Toll Like Receptor 3 (TLR3) Cascade TAS Reactome
Toll Like Receptor 4 (TLR4) Cascade TAS Reactome
Toll-like Receptor Cascades TAS Reactome
TRIF (TICAM1)-mediated TLR4 signaling TAS Reactome





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