Gene description for CSNK1A1
Gene name casein kinase 1, alpha 1
Gene symbol CSNK1A1
Other names/aliases CK1
CK1a
CKIa
HEL-S-77p
HLCDGP1
PRO2975
Species Homo sapiens
 Database cross references - CSNK1A1
ExoCarta ExoCarta_1452
Vesiclepedia VP_1452
Entrez Gene 1452
HGNC 2451
MIM 600505
UniProt P48729  
 CSNK1A1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Colorectal cancer cells 34887515    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Hepatocellular carcinoma cells 26054723    
Mesenchymal stem cells 36408942    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
 Gene ontology annotations for CSNK1A1
Molecular Function
    protein kinase activity GO:0004672 ISS
    protein kinase activity GO:0004672 TAS
    protein serine/threonine kinase activity GO:0004674 EXP
    protein serine/threonine kinase activity GO:0004674 IBA
    protein serine/threonine kinase activity GO:0004674 IDA
    protein serine/threonine kinase activity GO:0004674 IMP
    protein serine/threonine kinase activity GO:0004674 ISS
    protein serine/threonine kinase activity GO:0004674 TAS
    3-phosphoinositide-dependent protein kinase activity GO:0004676 IEA
    DNA-dependent protein kinase activity GO:0004677 IEA
    AMP-activated protein kinase activity GO:0004679 IEA
    eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 IEA
    ribosomal protein S6 kinase activity GO:0004711 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    histone H3S10 kinase activity GO:0035175 IEA
    histone H3T11 kinase activity GO:0035402 IEA
    histone H3T6 kinase activity GO:0035403 IEA
    histone H2AXS139 kinase activity GO:0035979 IEA
    histone H3S28 kinase activity GO:0044022 IEA
    histone H4S1 kinase activity GO:0044023 IEA
    histone H2AS1 kinase activity GO:0044024 IEA
    histone H2BS14 kinase activity GO:0044025 IEA
    histone H3T3 kinase activity GO:0072354 IEA
    histone H2AS121 kinase activity GO:0072371 IEA
    Rho-dependent protein serine/threonine kinase activity GO:0072518 IEA
    protein serine kinase activity GO:0106310 IEA
    histone H2BS36 kinase activity GO:0140823 IEA
    histone H3S57 kinase activity GO:0140855 IEA
    histone H3T45 kinase activity GO:0140857 IEA
    histone H2AT120 kinase activity GO:1990244 IEA
Biological Process
    chromatin remodeling GO:0006338 IEA
    protein phosphorylation GO:0006468 IDA
    Golgi organization GO:0007030 IMP
    signal transduction GO:0007165 IBA
    cell surface receptor signaling pathway GO:0007166 TAS
    Wnt signaling pathway GO:0016055 TAS
    peptidyl-serine phosphorylation GO:0018105 IMP
    viral protein processing GO:0019082 TAS
    cellular response to nutrient GO:0031670 IDA
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 IDA
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 IMP
    positive regulation of Rho protein signal transduction GO:0035025 IDA
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 NAS
    intermediate filament cytoskeleton organization GO:0045104 IMP
    cell division GO:0051301 IEA
    negative regulation of canonical Wnt signaling pathway GO:0090090 IBA
    negative regulation of canonical Wnt signaling pathway GO:0090090 IC
    negative regulation of canonical Wnt signaling pathway GO:0090090 IMP
    negative regulation of NLRP3 inflammasome complex assembly GO:1900226 ISS
    positive regulation of TORC1 signaling GO:1904263 IDA
Subcellular Localization
    kinetochore GO:0000776 IEA
    nucleus GO:0005634 IBA
    cytoplasm GO:0005737 IBA
    centrosome GO:0005813 IDA
    spindle GO:0005819 ISS
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    mRNA cleavage and polyadenylation specificity factor complex GO:0005847 IDA
    cilium GO:0005929 TAS
    membrane GO:0016020 HDA
    nuclear speck GO:0016607 IDA
    beta-catenin destruction complex GO:0030877 IDA
    beta-catenin destruction complex GO:0030877 NAS
    ciliary basal body GO:0036064 ISS
    keratin filament GO:0045095 IDA
 Experiment description of studies that identified CSNK1A1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 426
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 427
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
8
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
9
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
10
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
11
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
12
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
13
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
14
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
15
Experiment ID 235
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
16
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
17
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
18
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
19
Experiment ID 434
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
20
Experiment ID 435
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CSNK1A1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CRBN  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
2 LIG4 3981
Affinity Capture-MS Homo sapiens
3 VPS35 55737
Affinity Capture-MS Homo sapiens
4 UBE2H 7328
Affinity Capture-MS Homo sapiens
5 SMC3 9126
Affinity Capture-MS Homo sapiens
6 HDAC4  
Affinity Capture-MS Homo sapiens
7 ZBTB21  
Affinity Capture-MS Homo sapiens
8 PPP1CB 5500
Co-fractionation Homo sapiens
9 EPM2AIP1 9852
Affinity Capture-MS Homo sapiens
10 HDAC2 3066
Affinity Capture-MS Homo sapiens
11 PHF6  
Affinity Capture-MS Homo sapiens
12 SNX24  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 OCLN 100506658
Reconstituted Complex Homo sapiens
14 KSR1  
Affinity Capture-MS Homo sapiens
15 ATP6V1A 523
Affinity Capture-MS Homo sapiens
16 PPIE 10450
Affinity Capture-MS Homo sapiens
17 SH3BP4 23677
Affinity Capture-MS Homo sapiens
18 SH3GL1 6455
Affinity Capture-MS Homo sapiens
19 HIST1H1D 3007
Affinity Capture-MS Homo sapiens
20 YWHAE 7531
Affinity Capture-MS Homo sapiens
21 NFATC1 4772
Affinity Capture-MS Homo sapiens
22 E2F1 1869
Affinity Capture-Western Homo sapiens
23 APC  
Biochemical Activity Homo sapiens
24 KIF20A 10112
Affinity Capture-MS Homo sapiens
25 NPEPPS 9520
Affinity Capture-MS Homo sapiens
26 ATM 472
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
27 KPNA2 3838
Affinity Capture-MS Homo sapiens
28 CAND1 55832
Affinity Capture-MS Homo sapiens
29 CBY1  
Affinity Capture-MS Homo sapiens
30 GFPT1 2673
Affinity Capture-MS Homo sapiens
31 COPA 1314
Affinity Capture-MS Homo sapiens
32 KIF1B 23095
Affinity Capture-MS Homo sapiens
33 GCN1L1 10985
Affinity Capture-MS Homo sapiens
34 SOX2  
Affinity Capture-MS Homo sapiens
35 ZNF618  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 RPS3 6188
Affinity Capture-MS Homo sapiens
37 HMMR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 PPP1CC 5501
Two-hybrid Homo sapiens
39 RAI1 10743
Affinity Capture-MS Homo sapiens
40 KIF13B 23303
Affinity Capture-MS Homo sapiens
41 CPSF2 53981
Co-fractionation Homo sapiens
42 TEX264 51368
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 FAM83D 81610
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 ERF  
Co-purification Homo sapiens
45 PFKL 5211
Affinity Capture-MS Homo sapiens
46 BCL10  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
47 OGDH 4967
Co-fractionation Homo sapiens
48 LRP6 4040
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 DYNC1LI2 1783
Co-fractionation Homo sapiens
50 LRP5 4041
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 KIF23 9493
Affinity Capture-MS Homo sapiens
52 PPP2R5D 5528
Co-fractionation Homo sapiens
53 FAM83B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 RASAL2 9462
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 CPSF4  
Co-fractionation Homo sapiens
56 CPSF1 29894
Co-fractionation Homo sapiens
57 LIG1 3978
Co-fractionation Homo sapiens
58 COPS5 10987
Affinity Capture-Western Homo sapiens
59 SEC23IP 11196
Co-fractionation Homo sapiens
60 NFATC3 4775
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 AXIN1  
Phenotypic Suppression Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
62 TIAM1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
63 FAM207A  
Co-crystal Structure Homo sapiens
64 DYNLL1 8655
Affinity Capture-MS Homo sapiens
65 RCC1 1104
Co-purification Homo sapiens
66 ITGA4 3676
Affinity Capture-MS Homo sapiens
67 VCAM1 7412
Affinity Capture-MS Homo sapiens
68 POTEC  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 CLTC 1213
Affinity Capture-MS Homo sapiens
70 GTSE1 51512
Affinity Capture-MS Homo sapiens
71 SEC23A 10484
Affinity Capture-MS Homo sapiens
72 BTRC 8945
Affinity Capture-MS Homo sapiens
73 ARHGAP22 58504
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 CSNK1D 1453
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 SYT9 143425
Co-purification Homo sapiens
76 TNFRSF1B  
Biochemical Activity Homo sapiens
77 SSMEM1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 HSPD1 3329
Affinity Capture-MS Homo sapiens
79 KIF14 9928
Affinity Capture-MS Homo sapiens
80 FAS 355
Proximity Label-MS Homo sapiens
81 NINL  
Proximity Label-MS Homo sapiens
82 RBMX 27316
Co-fractionation Homo sapiens
83 UNC45A 55898
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
84 XRCC4  
Affinity Capture-MS Homo sapiens
85 Fam83d  
Affinity Capture-MS Mus musculus
86 ADAP1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
87 RPL27 6155
Affinity Capture-MS Homo sapiens
88 MYO18A 399687
Affinity Capture-MS Homo sapiens
89 LMNA 4000
Proximity Label-MS Homo sapiens
90 IPO7 10527
Affinity Capture-MS Homo sapiens
91 MCC 4163
Affinity Capture-MS Homo sapiens
92 C6orf141  
Affinity Capture-MS Homo sapiens
93 EMD 2010
Proximity Label-MS Homo sapiens
94 NCKIPSD 51517
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 SEC13 6396
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
96 ANKRD17 26057
Affinity Capture-MS Homo sapiens
97 RPL4 6124
Affinity Capture-MS Homo sapiens
98 AHSA1 10598
Affinity Capture-MS Homo sapiens
99 FAM83G  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
100 MARS 4141
Affinity Capture-MS Homo sapiens
101 Sec24c  
Affinity Capture-MS Mus musculus
102 YWHAG 7532
Affinity Capture-MS Homo sapiens
103 BACH1 571
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
104 ACACA 31
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
105 UBAC2 337867
Affinity Capture-MS Homo sapiens
106 SMARCA4 6597
Affinity Capture-Western Homo sapiens
107 MAPT  
Biochemical Activity Homo sapiens
108 KDM1A 23028
Affinity Capture-Western Homo sapiens
109 CDH1 999
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
110 CHMP4B 128866
Affinity Capture-MS Homo sapiens
111 RPA2 6118
Affinity Capture-MS Homo sapiens
112 TRIM21 6737
Affinity Capture-MS Homo sapiens
113 NTRK1 4914
Affinity Capture-MS Homo sapiens
114 CORO1B 57175
Co-fractionation Homo sapiens
115 GLI3 2737
Biochemical Activity Homo sapiens
116 OPA1 4976
Affinity Capture-MS Homo sapiens
117 ATP5C1 509
Affinity Capture-MS Homo sapiens
118 CTNNB1 1499
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Biochemical Activity Homo sapiens
119 PARP1 142
Proximity Label-MS Homo sapiens
120 AGR2 10551
Affinity Capture-MS Homo sapiens
121 YWHAQ 10971
Affinity Capture-MS Homo sapiens
122 MALT1 10892
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
123 RPN1 6184
Affinity Capture-MS Homo sapiens
124 CSNK1E 1454
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
125 MZT2A  
Affinity Capture-MS Homo sapiens
126 NOL4  
Affinity Capture-MS Homo sapiens
127 DYNLL2 140735
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
128 MBD3 53615
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
129 KCTD3  
Affinity Capture-MS Homo sapiens
130 RPS15A 6210
Affinity Capture-MS Homo sapiens
131 CEBPA  
Protein-peptide Homo sapiens
132 TNPO1 3842
Affinity Capture-MS Homo sapiens
133 HMGB2 3148
Co-purification Homo sapiens
134 POTEB3 102724631
Affinity Capture-MS Homo sapiens
135 LARP1 23367
Affinity Capture-MS Homo sapiens
136 MAT2A 4144
Affinity Capture-MS Homo sapiens
137 ANLN 54443
Affinity Capture-MS Homo sapiens
138 CAD 790
Affinity Capture-MS Homo sapiens
139 PHLPP1  
Biochemical Activity Homo sapiens
140 ATG16L1 55054
Affinity Capture-MS Homo sapiens
141 smo  
Biochemical Activity Drosophila melanogaster
142 IMPA2 3613
Affinity Capture-MS Homo sapiens
143 HERC1 8925
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
144 TUBB 203068
Affinity Capture-MS Homo sapiens
145 FAM170A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
146 GMPPB 29925
Affinity Capture-MS Homo sapiens
147 C1orf111  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
148 DBR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
149 TMPO 7112
Affinity Capture-MS Homo sapiens
150 LBR 3930
Affinity Capture-MS Homo sapiens
151 XPO1 7514
Affinity Capture-MS Homo sapiens
152 ECT2 1894
Affinity Capture-MS Homo sapiens
153 LMO7 4008
Affinity Capture-MS Homo sapiens
154 LAMP1 3916
Proximity Label-MS Homo sapiens
155 NFKBIA  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
156 IFI30  
Co-fractionation Homo sapiens
157 MZT2B 80097
Affinity Capture-MS Homo sapiens
158 RPL3 6122
Affinity Capture-MS Homo sapiens
159 DAB2IP 153090
Affinity Capture-MS Homo sapiens
160 PDE4D  
Biochemical Activity Homo sapiens
161 CARD11  
Affinity Capture-Western Homo sapiens
162 HMGB1 3146
Co-purification Homo sapiens
163 EGFR 1956
Affinity Capture-MS Homo sapiens
Negative Genetic Homo sapiens
164 SEPT11 55752
Affinity Capture-MS Homo sapiens
165 SEC61A1 29927
Affinity Capture-MS Homo sapiens
166 MDM4  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
167 RIPK4  
Affinity Capture-MS Homo sapiens
168 WEE1 7465
Affinity Capture-MS Homo sapiens
169 PPP2CA 5515
Affinity Capture-MS Homo sapiens
170 CYFIP1 23191
Affinity Capture-MS Homo sapiens
171 BLK 640
Affinity Capture-MS Homo sapiens
172 TUBA4A 7277
Affinity Capture-MS Homo sapiens
173 MYCN  
Affinity Capture-MS Homo sapiens
174 FKBP5 2289
Affinity Capture-MS Homo sapiens
175 STAT1 6772
Affinity Capture-MS Homo sapiens
176 MYC  
Affinity Capture-MS Homo sapiens
177 RPA3 6119
Affinity Capture-MS Homo sapiens
178 NIN 51199
Proximity Label-MS Homo sapiens
179 GNB2 2783
Two-hybrid Homo sapiens
180 GIGYF1  
Affinity Capture-MS Homo sapiens
181 SEC16A 9919
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
182 CPSF3 51692
Co-fractionation Homo sapiens
183 TTC9C 283237
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
184 HSPA4 3308
Biochemical Activity Homo sapiens
185 PSMC5 5705
Affinity Capture-MS Homo sapiens
186 CGN  
Affinity Capture-MS Homo sapiens
187 RAF1 5894
Affinity Capture-MS Homo sapiens
188 FLII 2314
Affinity Capture-MS Homo sapiens
189 DDRGK1 65992
Affinity Capture-MS Homo sapiens
190 RHOB 388
Proximity Label-MS Homo sapiens
191 PCM1 5108
Proximity Label-MS Homo sapiens
192 SIK2  
Affinity Capture-MS Homo sapiens
193 FTL 2512
Affinity Capture-MS Homo sapiens
194 IMPA1 3612
Affinity Capture-MS Homo sapiens
195 MDM2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
196 MGEA5 10724
Co-fractionation Homo sapiens
197 SLC25A13 10165
Affinity Capture-MS Homo sapiens
198 PRKDC 5591
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
199 PHGDH 26227
Affinity Capture-MS Homo sapiens
200 STUB1 10273
Affinity Capture-MS Homo sapiens
201 RAB18 22931
Affinity Capture-MS Homo sapiens
202 PIP5K1A 8394
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
203 DENND4C 55667
Affinity Capture-MS Homo sapiens
204 Cbx1  
Affinity Capture-MS Mus musculus
205 CDC25A  
Biochemical Activity Homo sapiens
206 RNF43  
Proximity Label-MS Homo sapiens
207 SNCA 6622
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
208 SSFA2 6744
Affinity Capture-MS Homo sapiens
209 NDUFS3 4722
Affinity Capture-MS Homo sapiens
210 LAMTOR1 55004
Proximity Label-MS Homo sapiens
211 IDH3B 3420
Affinity Capture-MS Homo sapiens
212 RFC1 5981
Affinity Capture-MS Homo sapiens
213 ACTG1 71
Affinity Capture-MS Homo sapiens
214 CSNK1A1L 122011
Affinity Capture-MS Homo sapiens
215 CPSF6 11052
Co-fractionation Homo sapiens
216 TP53 7157
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
217 USP34 9736
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
218 TUBG1 7283
Affinity Capture-MS Homo sapiens
219 RUVBL2 10856
Affinity Capture-MS Homo sapiens
220 CSNK1A1 1452
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
221 ITGB1 3688
Affinity Capture-MS Homo sapiens
222 WDR92 116143
Affinity Capture-MS Homo sapiens
223 RPA1 6117
Affinity Capture-MS Homo sapiens
224 TTC27 55622
Affinity Capture-MS Homo sapiens
225 MT1X 4501
Affinity Capture-MS Homo sapiens
226 HNRNPM 4670
Affinity Capture-MS Homo sapiens
227 SQSTM1 8878
Biochemical Activity Homo sapiens
228 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
229 MLH1 4292
Affinity Capture-MS Homo sapiens
230 FAM83F 113828
Affinity Capture-Western Homo sapiens
231 HSP90AA1 3320
Affinity Capture-MS Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Biochemical Activity Homo sapiens
232 FAM83H 286077
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
233 DDX58 23586
Affinity Capture-RNA Homo sapiens
234 MAP2K1 5604
Affinity Capture-MS Homo sapiens
235 ATP2A2 488
Affinity Capture-MS Homo sapiens
236 ATAD3A 55210
Affinity Capture-MS Homo sapiens
237 MPRIP 23164
Affinity Capture-MS Homo sapiens
238 CHRM3 1131
Reconstituted Complex Homo sapiens
239 PPP1R14A 94274
Reconstituted Complex Homo sapiens
Co-purification Homo sapiens
240 RPS28 6234
Affinity Capture-MS Homo sapiens
241 AFG3L2 10939
Affinity Capture-MS Homo sapiens
242 SNX22  
Affinity Capture-MS Homo sapiens
243 ACTA1 58
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
244 FAM110D  
Affinity Capture-MS Homo sapiens
245 MED12  
Affinity Capture-MS Homo sapiens
246 EIF3J 8669
Affinity Capture-MS Homo sapiens
247 WSB1 26118
Affinity Capture-Western Homo sapiens
248 GAPVD1 26130
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
249 CDK9 1025
Affinity Capture-MS Homo sapiens
250 ATP1A1 476
Affinity Capture-MS Homo sapiens
251 SEC23B 10483
Affinity Capture-MS Homo sapiens
252 STK11 6794
Negative Genetic Homo sapiens
253 XRCC6 2547
Affinity Capture-MS Homo sapiens
254 KRAS 3845
Negative Genetic Homo sapiens
255 SH3KBP1 30011
Affinity Capture-MS Homo sapiens
256 RAC1 5879
Affinity Capture-MS Homo sapiens
257 FABP5 2171
Affinity Capture-MS Homo sapiens
258 ATOH1  
Affinity Capture-Western Homo sapiens
259 PTCH1  
Affinity Capture-MS Homo sapiens
260 Uso1 56041
Affinity Capture-MS Mus musculus
261 CACYBP 27101
Co-fractionation Homo sapiens
262 ZNF217 7764
Affinity Capture-MS Homo sapiens
263 RANGAP1 5905
Affinity Capture-MS Homo sapiens
264 DBNDD1  
Affinity Capture-MS Homo sapiens
265 ZDBF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
266 BCR 613
Affinity Capture-MS Homo sapiens
267 NDUFB4 4710
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CSNK1A1 is involved
PathwayEvidenceSource
Activation of SMO TAS Reactome
Activation of SMO IEA Reactome
APC truncation mutants have impaired AXIN binding TAS Reactome
AXIN missense mutants destabilize the destruction complex TAS Reactome
Beta-catenin phosphorylation cascade TAS Reactome
CTNNB1 S33 mutants aren't phosphorylated TAS Reactome
CTNNB1 S37 mutants aren't phosphorylated TAS Reactome
CTNNB1 S45 mutants aren't phosphorylated TAS Reactome
CTNNB1 T41 mutants aren't phosphorylated TAS Reactome
Degradation of beta-catenin by the destruction complex TAS Reactome
Degradation of GLI2 by the proteasome IEA Reactome
Disassembly of the destruction complex and recruitment of AXIN to the membrane TAS Reactome
Disassembly of the destruction complex and recruitment of AXIN to the membrane IEA Reactome
Disease TAS Reactome
Diseases of signal transduction by growth factor receptors and second messengers TAS Reactome
GLI3 is processed to GLI3R by the proteasome TAS Reactome
Hedgehog 'off' state TAS Reactome
Hedgehog 'off' state IEA Reactome
Hedgehog 'on' state TAS Reactome
Hedgehog 'on' state IEA Reactome
Infectious disease TAS Reactome
Late SARS-CoV-2 Infection Events TAS Reactome
Maturation of nucleoprotein TAS Reactome
SARS-CoV Infections TAS Reactome
SARS-CoV-2 Infection TAS Reactome
Signal Transduction TAS Reactome
Signal Transduction IEA Reactome
Signaling by AMER1 mutants TAS Reactome
Signaling by APC mutants TAS Reactome
Signaling by AXIN mutants TAS Reactome
Signaling by CTNNB1 phospho-site mutants TAS Reactome
Signaling by GSK3beta mutants TAS Reactome
Signaling by Hedgehog TAS Reactome
Signaling by Hedgehog IEA Reactome
Signaling by WNT TAS Reactome
Signaling by WNT IEA Reactome
Signaling by WNT in cancer TAS Reactome
TCF dependent signaling in response to WNT TAS Reactome
TCF dependent signaling in response to WNT IEA Reactome
Translation of Structural Proteins TAS Reactome
Truncations of AMER1 destabilize the destruction complex TAS Reactome
Viral Infection Pathways TAS Reactome





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