Gene description for HDAC6
Gene name histone deacetylase 6
Gene symbol HDAC6
Other names/aliases CPBHM
HD6
JM21
PPP1R90
Species Homo sapiens
 Database cross references - HDAC6
ExoCarta ExoCarta_10013
Vesiclepedia VP_10013
Entrez Gene 10013
HGNC 14064
MIM 300272
UniProt Q9UBN7  
 HDAC6 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Thymus 23844026    
 Gene ontology annotations for HDAC6
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA
    transcription corepressor binding GO:0001222 IPI
    actin binding GO:0003779 IEA
    histone deacetylase activity GO:0004407 IBA
    histone deacetylase activity GO:0004407 IDA
    histone deacetylase activity GO:0004407 IMP
    protein binding GO:0005515 IPI
    beta-catenin binding GO:0008013 IPI
    microtubule binding GO:0008017 IDA
    microtubule binding GO:0008017 ISS
    zinc ion binding GO:0008270 IEA
    enzyme binding GO:0019899 ISS
    histone H3K14 deacetylase activity, hydrolytic mechanism GO:0031078 IEA
    polyubiquitin modification-dependent protein binding GO:0031593 IDA
    ubiquitin protein ligase binding GO:0031625 IPI
    histone H3K9 deacetylase activity, hydrolytic mechanism GO:0032129 IEA
    protein lysine deacetylase activity GO:0033558 IDA
    histone H4K16 deacetylase activity, hydrolytic mechanism GO:0034739 IEA
    histone deacetylase binding GO:0042826 IPI
    tubulin deacetylase activity GO:0042903 EXP
    tubulin deacetylase activity GO:0042903 IDA
    tubulin deacetylase activity GO:0042903 IMP
    tubulin deacetylase activity GO:0042903 ISS
    tubulin deacetylase activity GO:0042903 TAS
    alpha-tubulin binding GO:0043014 IDA
    ubiquitin binding GO:0043130 IEA
    acetylspermidine deacetylase activity GO:0047611 IDA
    tau protein binding GO:0048156 IDA
    tau protein binding GO:0048156 ISS
    tau protein binding GO:0048156 NAS
    tau protein binding GO:0048156 TAS
    beta-tubulin binding GO:0048487 IEA
    misfolded protein binding GO:0051787 EXP
    Hsp90 protein binding GO:0051879 IDA
    dynein complex binding GO:0070840 IDA
    histone H4K12 deacetylase activity, hydrolytic mechanism GO:0140937 IEA
    histone H4K5 deacetylase activity, hydrolytic mechanism GO:0180032 IEA
    histone H4K8 deacetylase activity, hydrolytic mechanism GO:0180033 IEA
    histone H3K4 deacetylase activity, hydrolytic mechanism GO:1990162 IEA
Biological Process
    protein polyubiquitination GO:0000209 IEA
    response to amphetamine GO:0001975 IEA
    protein deacetylation GO:0006476 IDA
    protein deacetylation GO:0006476 IMP
    protein deacetylation GO:0006476 TAS
    protein quality control for misfolded or incompletely synthesized proteins GO:0006515 IMP
    intracellular protein transport GO:0006886 IMP
    actin filament organization GO:0007015 IEA
    negative regulation of microtubule depolymerization GO:0007026 IEA
    regulation of autophagy GO:0010506 TAS
    positive regulation of epithelial cell migration GO:0010634 IMP
    negative regulation of hydrogen peroxide metabolic process GO:0010727 IC
    regulation of mitochondrion organization GO:0010821 IEA
    regulation of macroautophagy GO:0016241 IMP
    axonal transport of mitochondrion GO:0019896 IGI
    negative regulation of protein-containing complex assembly GO:0031333 IMP
    regulation of protein stability GO:0031647 IMP
    protein destabilization GO:0031648 IEA
    lysosome localization GO:0032418 IMP
    protein-containing complex disassembly GO:0032984 IEA
    positive regulation of peptidyl-serine phosphorylation GO:0033138 IMP
    cellular response to heat GO:0034605 TAS
    peptidyl-lysine deacetylation GO:0034983 IMP
    response to immobilization stress GO:0035902 IEA
    cellular response to topologically incorrect protein GO:0035967 IMP
    epigenetic regulation of gene expression GO:0040029 IBA
    erythrocyte enucleation GO:0043131 IEA
    ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway GO:0043162 IEA
    negative regulation of protein-containing complex disassembly GO:0043242 IMP
    regulation of fat cell differentiation GO:0045598 IEA
    negative regulation of gene expression, epigenetic GO:0045814 IMP
    negative regulation of proteolysis GO:0045861 IMP
    negative regulation of DNA-templated transcription GO:0045892 ISS
    collateral sprouting GO:0048668 IEA
    negative regulation of axon extension involved in axon guidance GO:0048843 IEA
    positive regulation of dendrite morphogenesis GO:0050775 IEA
    negative regulation of oxidoreductase activity GO:0051354 IC
    response to corticosterone GO:0051412 IEA
    response to misfolded protein GO:0051788 IMP
    positive regulation of synaptic transmission, glutamatergic GO:0051968 IEA
    cilium assembly GO:0060271 TAS
    regulation of microtubule-based movement GO:0060632 IC
    regulation of androgen receptor signaling pathway GO:0060765 TAS
    dendritic spine morphogenesis GO:0060997 IEA
    cilium disassembly GO:0061523 IDA
    cilium disassembly GO:0061523 IMP
    type 2 mitophagy GO:0061734 IGI
    regulation of establishment of protein localization GO:0070201 IEA
    cellular response to hydrogen peroxide GO:0070301 IMP
    aggresome assembly GO:0070842 IMP
    polyubiquitinated misfolded protein transport GO:0070845 IMP
    response to growth factor GO:0070848 IMP
    cellular response to misfolded protein GO:0071218 IEA
    cellular response to parathyroid hormone stimulus GO:0071374 IEA
    response to dexamethasone GO:0071548 IEA
    tubulin deacetylation GO:0090042 IDA
    tubulin deacetylation GO:0090042 ISS
    tubulin deacetylation GO:0090042 TAS
    positive regulation of tubulin deacetylation GO:0090044 IEA
    polyamine deacetylation GO:0106047 IDA
    spermidine deacetylation GO:0106048 IDA
    positive regulation of cellular response to oxidative stress GO:1900409 IEA
    negative regulation of protein acetylation GO:1901984 IEA
    regulation of autophagy of mitochondrion GO:1903146 TAS
    positive regulation of cholangiocyte proliferation GO:1904056 IEA
    positive regulation of type 2 mitophagy GO:1905091 IEA
    negative regulation of aggrephagy GO:1905336 IDA
    positive regulation of signaling receptor activity GO:2000273 IMP
Subcellular Localization
    histone deacetylase complex GO:0000118 IBA
    histone deacetylase complex GO:0000118 IDA
    nucleus GO:0005634 ISS
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 ISS
    cytoplasm GO:0005737 TAS
    multivesicular body GO:0005771 TAS
    centrosome GO:0005813 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 ISS
    cytosol GO:0005829 TAS
    microtubule GO:0005874 IDA
    microtubule associated complex GO:0005875 IDA
    caveola GO:0005901 IDA
    inclusion body GO:0016234 IDA
    aggresome GO:0016235 IDA
    aggresome GO:0016235 TAS
    axon GO:0030424 ISS
    dendrite GO:0030425 ISS
    cell leading edge GO:0031252 IDA
    ciliary basal body GO:0036064 IDA
    perikaryon GO:0043204 ISS
    perinuclear region of cytoplasm GO:0048471 IDA
    axon cytoplasm GO:1904115 IEA
 Experiment description of studies that identified HDAC6 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for HDAC6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
2 ADRBK1 156
Biochemical Activity Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
3 ZNF354C  
Affinity Capture-Western Homo sapiens
4 MCM7 4176
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 LSP1 4046
Affinity Capture-MS Homo sapiens
6 ISG15 9636
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
7 TUBB2A 7280
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
8 OR10H1  
Affinity Capture-MS Homo sapiens
9 CLIP1 6249
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
10 GTF3C5 9328
Affinity Capture-MS Homo sapiens
11 EEF1G 1937
Affinity Capture-MS Homo sapiens
12 SLC35G1  
Affinity Capture-MS Homo sapiens
13 TMEM161A  
Affinity Capture-MS Homo sapiens
14 KPNA1 3836
Reconstituted Complex Homo sapiens
15 KDM5C  
Negative Genetic Homo sapiens
16 DLST 1743
Affinity Capture-MS Homo sapiens
17 TARDBP 23435
Affinity Capture-RNA Homo sapiens
18 ATP13A2  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
19 YWHAE 7531
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
20 ABCF3 55324
Affinity Capture-MS Homo sapiens
21 ADRB2  
PCA Homo sapiens
22 PBRM1 55193
Negative Genetic Homo sapiens
23 MIIP 60672
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
24 Tubb5 29214
Reconstituted Complex Rattus norvegicus
Reconstituted Complex Rattus norvegicus
Biochemical Activity Rattus norvegicus
25 FAM65B  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
26 TRIM33 51592
Affinity Capture-MS Homo sapiens
27 PTEN 5728
Affinity Capture-MS Homo sapiens
28 UBC 7316
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
PCA Homo sapiens
29 EFCAB1  
Affinity Capture-MS Homo sapiens
30 CCT6B 10693
Affinity Capture-MS Homo sapiens
31 SAP30 8819
Co-fractionation Homo sapiens
32 HIST1H2BL 8340
Affinity Capture-MS Homo sapiens
33 PDHB 5162
Affinity Capture-MS Homo sapiens
34 PIK3CA 5290
Negative Genetic Homo sapiens
35 PRKDC 5591
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
36 MOCS1  
Affinity Capture-MS Homo sapiens
37 PTOV1  
Protein-peptide Homo sapiens
38 DNAJB6 10049
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
39 Pum2  
Two-hybrid Mus musculus
40 PPP1CC 5501
Co-purification Homo sapiens
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
41 KIAA1429 25962
Affinity Capture-MS Homo sapiens
42 UBD  
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
43 TRIM28 10155
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
44 YWHAZ 7534
Biochemical Activity Homo sapiens
45 MLLT4 4301
Affinity Capture-Western Homo sapiens
46 SIRT2 22933
Affinity Capture-Western Homo sapiens
47 CEP70  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
48 EEF1B2 1933
Affinity Capture-MS Homo sapiens
49 KIF23 9493
Affinity Capture-MS Homo sapiens
50 MCM2 4171
Affinity Capture-MS Homo sapiens
51 ZNF518A 9849
Affinity Capture-MS Homo sapiens
52 MRPS36 92259
Affinity Capture-MS Homo sapiens
53 IGFBP2 3485
Affinity Capture-MS Homo sapiens
54 ERBB3 2065
PCA Homo sapiens
55 PIGF  
Affinity Capture-MS Homo sapiens
56 FAM83D 81610
Affinity Capture-MS Homo sapiens
57 DIAPH3 81624
Affinity Capture-Western Homo sapiens
58 TRIM50  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
59 VKORC1 79001
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
60 COQ3  
Affinity Capture-MS Homo sapiens
61 CDC42BPB 9578
Affinity Capture-MS Homo sapiens
62 ACTR1A 10121
Affinity Capture-Western Homo sapiens
63 SYK 6850
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
64 TULP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 DDX58 23586
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
66 HIST1H3A 8350
Reconstituted Complex Homo sapiens
67 HIST4H4 121504
Protein-peptide Homo sapiens
68 FBXO11  
Protein-peptide Homo sapiens
69 DYNLL1 8655
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
70 BCOR  
Affinity Capture-Western Homo sapiens
71 RPS6 6194
Co-fractionation Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
72 PRDX4 10549
Two-hybrid Homo sapiens
73 MECP2 4204
Affinity Capture-MS Homo sapiens
74 PKN3 29941
Affinity Capture-MS Homo sapiens
75 TIMM50 92609
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 SETD1A 9739
Affinity Capture-MS Homo sapiens
77 ATXN3 4287
Reconstituted Complex Homo sapiens
78 CTTNBP2NL  
Proximity Label-MS Homo sapiens
79 ERBB2 2064
PCA Homo sapiens
80 WRAP73 49856
Affinity Capture-MS Homo sapiens
81 GSK3B 2932
Affinity Capture-Western Homo sapiens
82 KIF14 9928
Affinity Capture-MS Homo sapiens
83 ATAD3A 55210
Affinity Capture-MS Homo sapiens
84 HSPA8 3312
Affinity Capture-MS Homo sapiens
85 RASSF2 9770
Proximity Label-MS Homo sapiens
86 MAPK1 5594
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
87 LCOR 84458
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
88 AURKA 6790
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
89 LINC01588  
Affinity Capture-MS Homo sapiens
90 BANP  
Affinity Capture-Western Homo sapiens
91 DLD 1738
Affinity Capture-MS Homo sapiens
92 DNAJB8 165721
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
93 BRIP1  
Affinity Capture-MS Homo sapiens
94 MAPK3 5595
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
95 IPO7 10527
Affinity Capture-MS Homo sapiens
96 USP10 9100
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
97 CDKN1A  
Reconstituted Complex Homo sapiens
98 ZBTB16  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
99 IGF1R 3480
Negative Genetic Homo sapiens
100 BRMS1 25855
Affinity Capture-Western Homo sapiens
101 JDP2  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
102 TUBA1A 7846
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
103 MAPRE1 22919
Affinity Capture-Western Homo sapiens
104 ZMYM1 79830
Affinity Capture-MS Homo sapiens
105 ABT1 29777
Affinity Capture-MS Homo sapiens
106 POLA2  
Two-hybrid Homo sapiens
107 MEF2B  
Affinity Capture-Western Homo sapiens
108 TPPP 11076
Reconstituted Complex Homo sapiens
109 BRCA2 675
Negative Genetic Homo sapiens
110 TUBB2B 347733
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
111 RAMP1  
Affinity Capture-MS Homo sapiens
112 MAPT  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
113 CIRH1A 84916
Affinity Capture-MS Homo sapiens
114 MKRN2 23609
Affinity Capture-RNA Homo sapiens
115 TUBA1B 10376
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
116 VCP 7415
Affinity Capture-Western Homo sapiens
117 TRIM21 6737
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
118 NTRK1 4914
Affinity Capture-MS Homo sapiens
119 SLX1A  
Affinity Capture-MS Homo sapiens
120 PDHX 8050
Affinity Capture-MS Homo sapiens
121 CHEK1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
122 LPIN3 64900
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
123 POLDIP2 26073
Two-hybrid Homo sapiens
124 XPOT 11260
Affinity Capture-MS Homo sapiens
125 ULK1  
Affinity Capture-Western Homo sapiens
126 APOBEC3G  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
127 ACTB 60
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
128 TUBA1C 84790
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
129 MYH10 4628
Affinity Capture-Western Homo sapiens
130 UBE2D3 7323
Biochemical Activity Homo sapiens
131 DBT 1629
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
132 ITCH 83737
Affinity Capture-MS Homo sapiens
133 ATF3  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
134 Ksr1  
Affinity Capture-MS Mus musculus
135 CYLD  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
136 BBS10  
Two-hybrid Homo sapiens
137 LOC388882  
Affinity Capture-MS Homo sapiens
138 PXN 5829
Co-localization Homo sapiens
FRET Homo sapiens
Affinity Capture-Western Homo sapiens
139 UTP15 84135
Affinity Capture-MS Homo sapiens
140 BAG3 9531
Affinity Capture-Luminescence Homo sapiens
141 CD40 958
Affinity Capture-MS Homo sapiens
142 TBC1D16  
Affinity Capture-MS Homo sapiens
143 DNAJB14  
Affinity Capture-MS Homo sapiens
144 HSPA5 3309
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
145 PLAA 9373
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
146 TUBB 203068
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
147 PAFAH1B1 5048
Co-fractionation Homo sapiens
148 AK2 204
Affinity Capture-MS Homo sapiens
149 BAX 581
Affinity Capture-Western Homo sapiens
150 NR4A1  
Affinity Capture-MS Homo sapiens
151 NASP 4678
Two-hybrid Homo sapiens
152 Tuba1a 64158
Reconstituted Complex Rattus norvegicus
Reconstituted Complex Rattus norvegicus
Biochemical Activity Rattus norvegicus
153 BCKDHB 594
Affinity Capture-MS Homo sapiens
154 XPO1 7514
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
155 BOLA3  
Affinity Capture-MS Homo sapiens
156 FAT1 2195
Affinity Capture-Western Homo sapiens
157 NR0B2  
Reconstituted Complex Homo sapiens
158 CTNNB1 1499
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
159 TUBB4B 10383
Affinity Capture-MS Homo sapiens
160 RPL36A 6173
Co-fractionation Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
161 PHIP 55023
Affinity Capture-MS Homo sapiens
162 CUL3 8452
Affinity Capture-Western Homo sapiens
163 NR3C1 2908
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
164 ERBB4 2066
PCA Homo sapiens
165 CTTN 2017
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
166 COQ4  
Affinity Capture-MS Homo sapiens
167 EGFR 1956
Affinity Capture-Western Homo sapiens
PCA Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
PCA Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-Western Homo sapiens
168 HES1 3280
Two-hybrid Homo sapiens
169 FNTA 2339
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
170 FOXL1  
Affinity Capture-MS Homo sapiens
171 DYSF 8291
Affinity Capture-Western Homo sapiens
172 CUL1 8454
Affinity Capture-Western Homo sapiens
173 DNAJA1 3301
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
174 NXF1 10482
Affinity Capture-RNA Homo sapiens
175 RANBP9 10048
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
176 CTCFL  
Affinity Capture-MS Homo sapiens
177 BCL3  
Affinity Capture-Western Homo sapiens
178 RNF145  
Affinity Capture-MS Homo sapiens
179 NLRP3  
Affinity Capture-Western Homo sapiens
180 HDAC11  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
181 SAV1  
Proximity Label-MS Homo sapiens
182 UBE2E1  
Biochemical Activity Homo sapiens
183 CSNK2A2 1459
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
184 MAGEF1  
Affinity Capture-MS Homo sapiens
185 RUNX2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
186 GLOD5  
Affinity Capture-MS Homo sapiens
187 UBL7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
188 OTULIN 90268
Affinity Capture-MS Homo sapiens
189 MFN2 9927
Affinity Capture-Western Homo sapiens
190 DLAT 1737
Affinity Capture-MS Homo sapiens
191 NYAP2  
Affinity Capture-MS Homo sapiens
192 FTSJ3 117246
Affinity Capture-MS Homo sapiens
193 FNTB 2342
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
194 BIRC5  
Affinity Capture-Western Homo sapiens
195 UBE2D1 7321
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
196 HIF1A 3091
Affinity Capture-Western Homo sapiens
197 STUB1 10273
Affinity Capture-Western Homo sapiens
198 HSP90AB1 3326
Affinity Capture-MS Homo sapiens
199 PSMB2 5690
Affinity Capture-Western Homo sapiens
200 RELA 5970
Affinity Capture-Western Homo sapiens
201 GRK5 2869
Affinity Capture-MS Homo sapiens
202 SNCA 6622
Co-localization Homo sapiens
203 SPICE1  
Affinity Capture-MS Homo sapiens
204 LINC00624  
Protein-RNA Homo sapiens
Affinity Capture-RNA Homo sapiens
205 PHB2 11331
Affinity Capture-MS Homo sapiens
206 SPOP  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
207 CDC20 991
Affinity Capture-Western Homo sapiens
208 SLMAP 7871
Proximity Label-MS Homo sapiens
209 ZNF75A  
Affinity Capture-MS Homo sapiens
210 SMAD7  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
211 POLR1B 84172
Two-hybrid Homo sapiens
212 DOCK5 80005
Affinity Capture-MS Homo sapiens
213 NACAD  
Two-hybrid Homo sapiens
214 GSK3A 2931
Affinity Capture-Western Homo sapiens
215 APEX1 328
Affinity Capture-RNA Homo sapiens
216 RPA1 6117
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
217 BCKDHA 593
Affinity Capture-MS Homo sapiens
218 PDHA1 5160
Affinity Capture-MS Homo sapiens
219 MOB1A 55233
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
220 SQSTM1 8878
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
221 G3BP1 10146
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
222 HSPB1 3315
Affinity Capture-Western Homo sapiens
223 ELAVL1 1994
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
224 MLH1 4292
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
225 HSP90AA1 3320
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
226 SHMT2 6472
Affinity Capture-RNA Homo sapiens
227 Hdac6  
Affinity Capture-MS Mus musculus
228 MAP7D3 79649
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
229 CDK1 983
Affinity Capture-Western Homo sapiens
230 LPXN 9404
Two-hybrid Homo sapiens
231 DYNC1H1 1778
Affinity Capture-Western Homo sapiens
232 HNRNPA1 3178
Affinity Capture-MS Homo sapiens
233 UBB 7314
Affinity Capture-MS Homo sapiens
234 DDIT3 1649
Affinity Capture-Western Homo sapiens
235 SKOR1  
Affinity Capture-MS Homo sapiens
236 ZNF205 7755
Two-hybrid Homo sapiens
237 LRRK2 120892
Affinity Capture-Western Homo sapiens
238 HBA1 3039
Affinity Capture-MS Homo sapiens
239 PRKCA 5578
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
240 FBP1 2203
Two-hybrid Homo sapiens
241 MYD88 4615
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
242 RELB  
Affinity Capture-MS Homo sapiens
243 CBFA2T3  
Affinity Capture-Western Homo sapiens
244 ZNF10  
Affinity Capture-MS Homo sapiens
245 GEMIN5 25929
Affinity Capture-MS Homo sapiens
246 BRD1 23774
Affinity Capture-MS Homo sapiens
247 XRCC6 2547
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
248 FOXR1  
Affinity Capture-MS Homo sapiens
249 IFRD2 7866
Affinity Capture-MS Homo sapiens
250 CCDC96  
Affinity Capture-MS Homo sapiens
251 OGDH 4967
Affinity Capture-MS Homo sapiens
252 CFTR 1080
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
253 PRMT1 3276
Affinity Capture-MS Homo sapiens
254 CAV1 857
Affinity Capture-Western Homo sapiens
255 ZNF217 7764
Co-fractionation Homo sapiens
256 CPT1A 1374
Affinity Capture-MS Homo sapiens
257 NEDD8 4738
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
258 EP300 2033
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
259 TEKT4  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
260 KCNAB3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which HDAC6 is involved
PathwayEvidenceSource
Aggrephagy TAS Reactome
Aggrephagy IEA Reactome
Autophagy IEA Reactome
Autophagy TAS Reactome
Cellular response to heat stress TAS Reactome
Cellular responses to stimuli TAS Reactome
Cellular responses to stress TAS Reactome
Chaperone Mediated Autophagy IEA Reactome
Cilium Assembly TAS Reactome
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants TAS Reactome
Constitutive Signaling by NOTCH1 PEST Domain Mutants TAS Reactome
Disease TAS Reactome
Diseases of signal transduction by growth factor receptors and second messengers TAS Reactome
Gene expression (Transcription) TAS Reactome
Gene expression (Transcription) IEA Reactome
Generic Transcription Pathway TAS Reactome
Generic Transcription Pathway IEA Reactome
HSF1 activation TAS Reactome
Late endosomal microautophagy IEA Reactome
Macroautophagy TAS Reactome
Macroautophagy IEA Reactome
Notch-HLH transcription pathway TAS Reactome
NOTCH1 Intracellular Domain Regulates Transcription IEA Reactome
Organelle biogenesis and maintenance TAS Reactome
RNA Polymerase II Transcription TAS Reactome
RNA Polymerase II Transcription IEA Reactome
RUNX2 regulates bone development IEA Reactome
RUNX2 regulates osteoblast differentiation IEA Reactome
Selective autophagy TAS Reactome
Selective autophagy IEA Reactome
Signal Transduction IEA Reactome
Signaling by NOTCH IEA Reactome
Signaling by NOTCH1 IEA Reactome
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer TAS Reactome
Signaling by NOTCH1 in Cancer TAS Reactome
Signaling by NOTCH1 PEST Domain Mutants in Cancer TAS Reactome
Transcriptional regulation by RUNX2 TAS Reactome
Transcriptional regulation by RUNX2 IEA Reactome





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