Gene description for IKBKG
Gene name inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
Gene symbol IKBKG
Other names/aliases AMCBX1
FIP-3
FIP3
Fip3p
IKK-gamma
IMD33
IP
IP1
IP2
IPD2
NEMO
ZC2HC9
Species Homo sapiens
 Database cross references - IKBKG
ExoCarta ExoCarta_8517
Vesiclepedia VP_8517
Entrez Gene 8517
HGNC 5961
MIM 300248
UniProt Q9Y6K9  
 IKBKG identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Thymus 23844026    
 Gene ontology annotations for IKBKG
Molecular Function
    protein binding GO:0005515 IPI
    protein domain specific binding GO:0019904 IPI
    polyubiquitin modification-dependent protein binding GO:0031593 IDA
    ubiquitin protein ligase binding GO:0031625 IPI
    signaling adaptor activity GO:0035591 IDA
    identical protein binding GO:0042802 IPI
    protein homodimerization activity GO:0042803 IDA
    metal ion binding GO:0046872 IEA
    protein heterodimerization activity GO:0046982 IDA
    K63-linked polyubiquitin modification-dependent protein binding GO:0070530 IBA
    K63-linked polyubiquitin modification-dependent protein binding GO:0070530 IDA
    linear polyubiquitin binding GO:1990450 IDA
    transferrin receptor binding GO:1990459 IPI
Biological Process
    apoptotic process GO:0006915 TAS
    inflammatory response GO:0006954 TAS
    immune response GO:0006955 TAS
    DNA damage response GO:0006974 IDA
    DNA damage response GO:0006974 IMP
    canonical NF-kappaB signal transduction GO:0007249 IDA
    canonical NF-kappaB signal transduction GO:0007249 TAS
    response to virus GO:0009615 TAS
    positive regulation of macroautophagy GO:0016239 ISS
    defense response to bacterium GO:0042742 IDA
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 IBA
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 IDA
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 IDA
    anoikis GO:0043276 ISS
    innate immune response GO:0045087 TAS
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    T cell receptor signaling pathway GO:0050852 NAS
    positive regulation of T cell receptor signaling pathway GO:0050862 IDA
    positive regulation of NF-kappaB transcription factor activity GO:0051092 IDA
    positive regulation of NF-kappaB transcription factor activity GO:0051092 TAS
    establishment of vesicle localization GO:0051650 IMP
    protein-containing complex assembly GO:0065003 IDA
    positive regulation of ubiquitin-dependent protein catabolic process GO:2000060 TAS
Subcellular Localization
    ubiquitin ligase complex GO:0000151 IPI
    spindle pole GO:0000922 IDA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    IkappaB kinase complex GO:0008385 IBA
    IkappaB kinase complex GO:0008385 IDA
    IkappaB kinase complex GO:0008385 IPI
    IkappaB kinase complex GO:0008385 TAS
    protein-containing complex GO:0032991 IDA
    mitotic spindle GO:0072686 IDA
 Experiment description of studies that identified IKBKG in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for IKBKG
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MERTK 10461
Reconstituted Complex Homo sapiens
2 MUC13 56667
Affinity Capture-MS Homo sapiens
3 TNIP1 10318
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
4 MACROD1 28992
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
5 KPNA1 3836
Affinity Capture-Western Homo sapiens
6 GADD45G  
Reconstituted Complex Homo sapiens
7 TRIM26 7726
Affinity Capture-Western Homo sapiens
8 ABCA1 19
Two-hybrid Homo sapiens
9 ZZZ3  
Two-hybrid Homo sapiens
10 ZC3H12A  
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
11 UBC 7316
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
Protein-peptide Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
12 PNMAL1  
Reconstituted Complex Homo sapiens
13 RIPK1 8737
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
14 PRKDC 5591
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
15 MAFIP  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
16 SEPT9 10801
Reconstituted Complex Homo sapiens
17 NECAB3 63941
Reconstituted Complex Homo sapiens
18 KIF23 9493
Affinity Capture-Western Homo sapiens
19 CIAPIN1 57019
Co-fractionation Homo sapiens
20 TRIOBP 11078
Two-hybrid Homo sapiens
21 GRK4  
Reconstituted Complex Homo sapiens
22 ERC1 23085
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
23 SRC 6714
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
24 NCOA3  
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
25 RHOA 387
Reconstituted Complex Homo sapiens
26 HYPM  
Affinity Capture-MS Homo sapiens
27 RIPK2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
28 NSFL1C 55968
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
29 BTRC 8945
Affinity Capture-Western Homo sapiens
30 WDR5 11091
Reconstituted Complex Homo sapiens
31 SLU7  
Two-hybrid Homo sapiens
32 EEF1A1 1915
Two-hybrid Homo sapiens
33 NTMT1 28989
Reconstituted Complex Homo sapiens
34 RNF11 26994
Two-hybrid Homo sapiens
35 PPM1B 5495
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
36 TEC 7006
Reconstituted Complex Homo sapiens
37 HSP90AB4P 664618
Affinity Capture-MS Homo sapiens
38 SENP2 59343
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
39 MED7  
Two-hybrid Homo sapiens
40 RNF4 6047
Two-hybrid Homo sapiens
41 MAP3K2 10746
Reconstituted Complex Homo sapiens
42 TARBP2  
Two-hybrid Homo sapiens
43 PRKCB 5579
Reconstituted Complex Homo sapiens
44 SUPT5H 6829
Two-hybrid Homo sapiens
45 NOD2 64127
Affinity Capture-Western Homo sapiens
46 NLRX1 79671
Affinity Capture-Western Homo sapiens
47 MAPRE1 22919
Two-hybrid Homo sapiens
48 CALB1 793
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
49 GCC1 79571
Two-hybrid Homo sapiens
50 CASP6 839
Two-hybrid Homo sapiens
51 PARP1 142
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
52 PRPF18  
Two-hybrid Homo sapiens
53 Ikbkb 16150
Affinity Capture-Western Mus musculus
54 SRPK1 6732
Reconstituted Complex Homo sapiens
55 ANLN 54443
Affinity Capture-MS Homo sapiens
56 BIRC2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
57 EPAS1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
58 KCMF1 56888
Co-fractionation Homo sapiens
59 TNFRSF1A 7132
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
60 C19orf12  
Reconstituted Complex Homo sapiens
61 CUL3 8452
Affinity Capture-MS Homo sapiens
62 ATRIP  
Affinity Capture-Western Homo sapiens
63 GADD45GIP1  
Reconstituted Complex Homo sapiens
64 KANSL2  
Two-hybrid Homo sapiens
65 FADD 8772
Affinity Capture-Western Homo sapiens
66 GLO1 2739
Two-hybrid Homo sapiens
67 HLA-DQA1 3117
Two-hybrid Homo sapiens
68 HSPA1A 3303
Reconstituted Complex Homo sapiens
69 HSPA4 3308
Affinity Capture-Western Homo sapiens
70 TCEANC  
Reconstituted Complex Homo sapiens
71 AKT1 207
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
72 PSMB8 5696
Co-fractionation Homo sapiens
73 RELA 5970
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
74 TANK 10010
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 CDC37 11140
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 FRMD8 83786
Reconstituted Complex Homo sapiens
77 LCK 3932
Reconstituted Complex Homo sapiens
78 CETN3  
Reconstituted Complex Homo sapiens
79 APRT 353
Reconstituted Complex Homo sapiens
80 PLEKHJ1  
Reconstituted Complex Homo sapiens
81 CWF19L2  
Two-hybrid Homo sapiens
82 HSP90AA1 3320
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 ROS1  
Reconstituted Complex Homo sapiens
84 RAB11FIP1 80223
Affinity Capture-MS Homo sapiens
85 TBK1 29110
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
86 BCL2  
Affinity Capture-Western Homo sapiens
87 Cdc37 12539
Affinity Capture-MS Mus musculus
88 PRKCE 5581
Affinity Capture-Western Homo sapiens
89 ARPP19 10776
Reconstituted Complex Homo sapiens
90 RAB11A 8766
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
91 SHARPIN  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
92 SNW1 22938
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
93 CNTN2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
94 PTS  
Affinity Capture-MS Homo sapiens
95 RBCK1  
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
96 C19orf80  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
97 TRPC4AP  
Affinity Capture-Western Homo sapiens
98 TRAF1 7185
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
99 ATR  
Affinity Capture-Western Homo sapiens
100 KPNA6 23633
Affinity Capture-Western Homo sapiens
101 OSBPL10  
Two-hybrid Homo sapiens
102 SPRTN  
Affinity Capture-MS Homo sapiens
103 PSG11  
Affinity Capture-MS Homo sapiens
104 PIDD1  
Affinity Capture-Western Homo sapiens
105 DAPK1 1612
Reconstituted Complex Homo sapiens
106 MARCH2  
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
107 GFAP 2670
Two-hybrid Homo sapiens
108 ARL6IP4  
Reconstituted Complex Homo sapiens
109 HSP90AB1 3326
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
110 ATM 472
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
111 KIAA1598 57698
Reconstituted Complex Homo sapiens
112 SCLT1 132320
Reconstituted Complex Homo sapiens
113 PPP2R1B 5519
Affinity Capture-Western Homo sapiens
114 INHA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
115 BIRC3 330
Reconstituted Complex Homo sapiens
116 FAM196A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
117 POLR1E  
Affinity Capture-MS Homo sapiens
118 CUL1 8454
Affinity Capture-Western Homo sapiens
119 USP7 7874
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
120 GSK3B 2932
Co-localization Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
121 IRAK4 51135
Reconstituted Complex Homo sapiens
122 USP10 9100
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
123 TTYH2 94015
Reconstituted Complex Homo sapiens
124 CDKN1A  
Two-hybrid Homo sapiens
125 TAB3 257397
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
126 OPTN 10133
Affinity Capture-Western Homo sapiens
127 LYN 4067
Affinity Capture-Western Homo sapiens
128 TEK  
Reconstituted Complex Homo sapiens
129 PBXIP1 57326
Affinity Capture-Western Homo sapiens
130 PLK1 5347
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
131 PPP2CA 5515
Affinity Capture-Western Homo sapiens
132 LUC7L2 51631
Reconstituted Complex Homo sapiens
133 MALT1 10892
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
134 MZT2A  
Reconstituted Complex Homo sapiens
135 ID3  
Two-hybrid Homo sapiens
136 CYLD  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
137 UBXN6 80700
Affinity Capture-MS Homo sapiens
138 CD40 958
Affinity Capture-Western Homo sapiens
139 PSMA3 5684
Reconstituted Complex Homo sapiens
140 WHAMMP3  
Affinity Capture-MS Homo sapiens
141 RNF34  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
142 PHF7  
Reconstituted Complex Homo sapiens
143 POLR2E 5434
Two-hybrid Homo sapiens
144 NHP2 55651
Reconstituted Complex Homo sapiens
145 EGFR 1956
Two-hybrid Homo sapiens
PCA Homo sapiens
Affinity Capture-Luminescence Homo sapiens
146 RIPK4  
Affinity Capture-MS Homo sapiens
147 PRKD3 23683
Reconstituted Complex Homo sapiens
148 CDK2 1017
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
149 PRKCQ 5588
Affinity Capture-Western Homo sapiens
150 TPM1 7168
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
151 MYC  
Affinity Capture-Western Homo sapiens
152 DYNC1LI1 51143
FRET Homo sapiens
Far Western Homo sapiens
153 ZNF587  
Two-hybrid Homo sapiens
154 MIB2 142678
Affinity Capture-Western Homo sapiens
155 ARGLU1  
Reconstituted Complex Homo sapiens
156 MPRIP 23164
Two-hybrid Homo sapiens
157 HSP90AA2P 3324
Affinity Capture-MS Homo sapiens
158 PFDN5 5204
Reconstituted Complex Homo sapiens
159 ZRANB1 54764
Affinity Capture-MS Homo sapiens
160 TRIM5 85363
Affinity Capture-Western Homo sapiens
161 SURF6  
Affinity Capture-MS Homo sapiens
162 FGR 2268
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
163 RBM8A 9939
Reconstituted Complex Homo sapiens
164 TRAF3IP2  
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
165 TRIM13  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
166 TRAF2 7186
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
167 PRKY  
Affinity Capture-MS Homo sapiens
168 PSG1  
Affinity Capture-MS Homo sapiens
169 TP53 7157
Negative Genetic Homo sapiens
170 CCHCR1  
Two-hybrid Homo sapiens
171 EIF1AX 1964
Reconstituted Complex Homo sapiens
172 MYL5  
Reconstituted Complex Homo sapiens
173 FLT4  
Reconstituted Complex Homo sapiens
174 ARF5 381
Reconstituted Complex Homo sapiens
175 RPS12 6206
Reconstituted Complex Homo sapiens
176 AVPI1  
Reconstituted Complex Homo sapiens
177 CENPF 1063
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
178 BCL10  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
179 LPXN 9404
Reconstituted Complex Homo sapiens
180 JAK3 3718
Reconstituted Complex Homo sapiens
181 NRARP  
Reconstituted Complex Homo sapiens
182 NEFM 4741
Affinity Capture-MS Homo sapiens
183 JAK2 3717
Reconstituted Complex Homo sapiens
184 KLHL21 9903
Affinity Capture-Western Homo sapiens
185 NAP1L5  
Reconstituted Complex Homo sapiens
186 HBZ  
Reconstituted Complex Homo sapiens
187 MCM7 4176
Reconstituted Complex Homo sapiens
188 TP53BP1 7158
Negative Genetic Homo sapiens
189 CCAR1 55749
Affinity Capture-MS Homo sapiens
190 STK25 10494
Reconstituted Complex Homo sapiens
191 DNAJC8 22826
Reconstituted Complex Homo sapiens
192 KRT17 3872
Co-fractionation Homo sapiens
193 ZPR1 8882
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
194 CARD10  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
195 ID1  
Two-hybrid Homo sapiens
196 FLT3  
Reconstituted Complex Homo sapiens
197 MYO5C 55930
Two-hybrid Homo sapiens
198 RET 5979
Reconstituted Complex Homo sapiens
199 GNGT1  
Reconstituted Complex Homo sapiens
200 RPS6KB2  
Reconstituted Complex Homo sapiens
201 ARHGDIA 396
Reconstituted Complex Homo sapiens
202 TYRO3 7301
Reconstituted Complex Homo sapiens
203 MRFAP1L1  
Affinity Capture-MS Homo sapiens
204 TLR3  
Affinity Capture-Western Homo sapiens
205 D2HGDH 728294
Affinity Capture-MS Homo sapiens
206 AMMECR1L 83607
Reconstituted Complex Homo sapiens
207 CARD8  
Affinity Capture-Western Homo sapiens
208 CALCOCO2  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
209 IKBKE 9641
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
210 ATG16L1 55054
Affinity Capture-MS Homo sapiens
211 TCP11L1 55346
Reconstituted Complex Homo sapiens
212 MAVS 57506
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
213 Cmtm3  
Affinity Capture-Western Mus musculus
214 GEMIN2 8487
Reconstituted Complex Homo sapiens
215 SAMHD1 25939
Affinity Capture-Western Homo sapiens
216 SDCCAG8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
217 S100A2 6273
Affinity Capture-MS Homo sapiens
218 IRAK1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
219 PARK2  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
220 LMCD1 29995
Reconstituted Complex Homo sapiens
221 KPNA7  
Affinity Capture-Western Homo sapiens
222 KIR3DX1  
Reconstituted Complex Homo sapiens
223 MCM10 55388
Reconstituted Complex Homo sapiens
224 TNPO2 30000
Affinity Capture-Western Homo sapiens
225 TAB2  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
226 NRBF2  
Reconstituted Complex Homo sapiens
227 COPS3 8533
Affinity Capture-Western Homo sapiens
228 LZTR1 8216
Two-hybrid Homo sapiens
229 NFKB2 4791
Affinity Capture-MS Homo sapiens
230 TCP11  
Reconstituted Complex Homo sapiens
231 HCLS1 3059
Two-hybrid Homo sapiens
232 MAP4K1  
Affinity Capture-Western Homo sapiens
233 POLR2B 5431
Two-hybrid Homo sapiens
234 PA2G4 5036
Two-hybrid Homo sapiens
235 TAF7  
Two-hybrid Homo sapiens
236 C19orf57  
Reconstituted Complex Homo sapiens
237 POLR3A 11128
Two-hybrid Homo sapiens
238 KRT18 3875
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
239 NFKBIA  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
240 TRAF6 7189
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
241 ARNT 405
Affinity Capture-Western Homo sapiens
242 CARD11  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
243 RPL41  
Reconstituted Complex Homo sapiens
244 H1F0 3005
Reconstituted Complex Homo sapiens
245 ODAM  
Reconstituted Complex Homo sapiens
246 METTL21B  
Affinity Capture-MS Homo sapiens
247 MAP3K7  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
248 HNRNPCL2 440563
Affinity Capture-MS Homo sapiens
249 PIM2  
Reconstituted Complex Homo sapiens
250 HPD 3242
Two-hybrid Homo sapiens
251 CLIC1 1192
Two-hybrid Homo sapiens
252 CAAP1  
Affinity Capture-MS Homo sapiens
253 MTOR 2475
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
254 RAB11B 9230
Affinity Capture-MS Homo sapiens
255 HDLBP 3069
Co-fractionation Homo sapiens
256 SGK1  
Reconstituted Complex Homo sapiens
257 FYN 2534
Affinity Capture-Western Homo sapiens
258 TRIM40 135644
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
259 RBP1 5947
Two-hybrid Homo sapiens
260 GUCY1A3  
Two-hybrid Homo sapiens
261 CHUK 1147
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
262 XRCC5 7520
Affinity Capture-Western Homo sapiens
263 RBBP8  
Two-hybrid Homo sapiens
264 MAP3K14  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
265 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
266 LZIC 84328
Reconstituted Complex Homo sapiens
267 SMN1 6606
Affinity Capture-Western Homo sapiens
268 MTPN 136319
Affinity Capture-MS Homo sapiens
269 SPTBN2 6712
Affinity Capture-MS Homo sapiens
270 RNF31 55072
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
271 EPHA4 2043
Reconstituted Complex Homo sapiens
272 IKBKG 8517
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
273 RPTOR 57521
Affinity Capture-Western Homo sapiens
274 LENG8  
Two-hybrid Homo sapiens
275 CREBBP  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
276 DDX58 23586
Affinity Capture-Western Homo sapiens
Affinity Capture-RNA Homo sapiens
277 PDCL 5082
Reconstituted Complex Homo sapiens
278 DDIT3 1649
Two-hybrid Homo sapiens
279 TRIM37  
Affinity Capture-Western Homo sapiens
280 CDK13 8621
Affinity Capture-MS Homo sapiens
281 TRIM23 373
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
282 MYD88 4615
Reconstituted Complex Homo sapiens
283 STK11 6794
Negative Genetic Homo sapiens
284 STX11 8676
Two-hybrid Homo sapiens
285 NFKBIB  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
286 RBM34  
Reconstituted Complex Homo sapiens
287 SYT1 6857
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
288 CNOT7 29883
Reconstituted Complex Homo sapiens
289 TNFAIP3 7128
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
290 ENKD1  
Two-hybrid Homo sapiens
291 WWP1 11059
Two-hybrid Homo sapiens
292 RACGAP1 29127
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
293 SQSTM1 8878
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
294 GIT2 9815
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
295 TAB1 10454
Reconstituted Complex Homo sapiens
296 SASH1 23328
Affinity Capture-Western Homo sapiens
297 ZFAND5 7763
Affinity Capture-Western Homo sapiens
298 NLRP2  
Affinity Capture-Western Homo sapiens
299 MSH3 4437
Affinity Capture-MS Homo sapiens
300 NMRAL1 57407
Affinity Capture-Western Homo sapiens
301 PPP1CC 5501
Affinity Capture-Western Homo sapiens
302 TMA16  
Reconstituted Complex Homo sapiens
303 ZBTB3  
Two-hybrid Homo sapiens
304 PCK1 5105
Reconstituted Complex Homo sapiens
305 MUC1 4582
Affinity Capture-Western Homo sapiens
306 USP18  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
307 SEMA4C 54910
Affinity Capture-MS Homo sapiens
308 ALK 238
Reconstituted Complex Homo sapiens
309 INO80E  
Two-hybrid Homo sapiens
310 MLLT6  
Reconstituted Complex Homo sapiens
311 USP2  
Biochemical Activity Homo sapiens
312 ROR2 4920
Reconstituted Complex Homo sapiens
313 TPT1 7178
Reconstituted Complex Homo sapiens
314 LTBR 4055
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
315 DDX19B 11269
Reconstituted Complex Homo sapiens
316 KRT8 3856
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
317 TRIM41 90933
Reconstituted Complex Homo sapiens
318 COMMD7 149951
Affinity Capture-Western Homo sapiens
319 CPNE2 221184
Reconstituted Complex Homo sapiens
320 TCP10L  
Reconstituted Complex Homo sapiens
321 PLBD1 79887
Affinity Capture-MS Homo sapiens
322 PIAS4  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
323 HSP90B1 7184
Affinity Capture-Western Homo sapiens
324 HTT 3064
Reconstituted Complex Homo sapiens
325 TRIM14 9830
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
326 SYNC  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
327 GINS4  
Co-fractionation Homo sapiens
328 AIP 9049
Two-hybrid Homo sapiens
329 ITK 3702
Reconstituted Complex Homo sapiens
330 ANXA1 301
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
331 TSLP  
Reconstituted Complex Homo sapiens
332 USP32 84669
Affinity Capture-MS Homo sapiens
333 SSX2IP  
Two-hybrid Homo sapiens
334 BAG3 9531
Affinity Capture-Western Homo sapiens
335 VAMP3 9341
Reconstituted Complex Homo sapiens
336 ACBD6 84320
Reconstituted Complex Homo sapiens
337 TAX1BP1 8887
Two-hybrid Homo sapiens
338 EGLN3  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
339 HPCAL1 3241
Reconstituted Complex Homo sapiens
340 ASAP3 55616
Affinity Capture-Western Homo sapiens
341 ZNF835  
Two-hybrid Homo sapiens
342 ARF6 382
Reconstituted Complex Homo sapiens
343 IKBKB 3551
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
344 TRAF3 7187
Affinity Capture-Western Homo sapiens
345 TNIP2  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
346 PRKCI 5584
Two-hybrid Homo sapiens
347 FKBP5 2289
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
348 POLR2D  
Two-hybrid Homo sapiens
349 RBM26 64062
Affinity Capture-MS Homo sapiens
350 HDDC2 51020
Two-hybrid Homo sapiens
351 ADAP2  
Reconstituted Complex Homo sapiens
352 RPAP3 79657
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
353 NFKB1 4790
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
354 PSMB5 5693
Two-hybrid Homo sapiens
355 PPFIA1 8500
Co-fractionation Homo sapiens
356 RALBP1 10928
Co-localization Homo sapiens
357 PPP4C 5531
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
358 LGALS2  
Reconstituted Complex Homo sapiens
359 TUBG1 7283
Affinity Capture-Western Homo sapiens
360 TBC1D7  
Reconstituted Complex Homo sapiens
361 TNF  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
362 CCT8L2  
Affinity Capture-MS Homo sapiens
363 SYNGAP1  
Affinity Capture-MS Homo sapiens
364 OSGIN1  
Two-hybrid Homo sapiens
365 RNF7  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
366 GSTM3 2947
Affinity Capture-MS Homo sapiens
367 UBB 7314
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
368 RUSC1  
Affinity Capture-Western Homo sapiens
369 TRIM31  
Two-hybrid Homo sapiens
370 GTF2E1 2960
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
371 XRCC6 2547
Affinity Capture-Western Homo sapiens
372 ARNTL2  
Affinity Capture-MS Homo sapiens
373 TRIM29 23650
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
374 CUEDC1 404093
Reconstituted Complex Homo sapiens
375 GYG2  
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which IKBKG is involved
PathwayEvidenceSource
activated TAK1 mediates p38 MAPK activation TAS Reactome
Activation of NF-kappaB in B cells IEA Reactome
Activation of NF-kappaB in B cells TAS Reactome
Adaptive Immune System TAS Reactome
Adaptive Immune System IEA Reactome
Antigen processing-Cross presentation TAS Reactome
Antiviral mechanism by IFN-stimulated genes TAS Reactome
C-type lectin receptors (CLRs) TAS Reactome
Cellular responses to mechanical stimuli TAS Reactome
Cellular responses to stimuli TAS Reactome
Class I MHC mediated antigen processing & presentation TAS Reactome
CLEC7A (Dectin-1) signaling TAS Reactome
Cytokine Signaling in Immune system TAS Reactome
Cytosolic sensors of pathogen-associated DNA TAS Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta TAS Reactome
Death Receptor Signaling TAS Reactome
Deubiquitination TAS Reactome
Disease TAS Reactome
Diseases associated with the TLR signaling cascade TAS Reactome
Diseases of Immune System TAS Reactome
Downstream signaling events of B Cell Receptor (BCR) IEA Reactome
Downstream signaling events of B Cell Receptor (BCR) TAS Reactome
Downstream TCR signaling TAS Reactome
ER-Phagosome pathway TAS Reactome
Fc epsilon receptor (FCERI) signaling TAS Reactome
FCERI mediated NF-kB activation TAS Reactome
IkBA variant leads to EDA-ID TAS Reactome
IKBKB deficiency causes SCID TAS Reactome
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) TAS Reactome
IKK complex recruitment mediated by RIP1 TAS Reactome
Immune System TAS Reactome
Immune System IEA Reactome
Infectious disease TAS Reactome
Innate Immune System TAS Reactome
Interferon Signaling TAS Reactome
Interleukin-1 family signaling TAS Reactome
Interleukin-1 signaling TAS Reactome
Interleukin-17 signaling TAS Reactome
IRAK1 recruits IKK complex TAS Reactome
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation TAS Reactome
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 TAS Reactome
MAP kinase activation TAS Reactome
MAP3K8 (TPL2)-dependent MAPK1/3 activation TAS Reactome
Metabolism of proteins TAS Reactome
MyD88 cascade initiated on plasma membrane TAS Reactome
MyD88 dependent cascade initiated on endosome TAS Reactome
MyD88-independent TLR4 cascade TAS Reactome
MyD88:MAL(TIRAP) cascade initiated on plasma membrane TAS Reactome
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 TAS Reactome
NOD1/2 Signaling Pathway TAS Reactome
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways TAS Reactome
Ovarian tumor domain proteases TAS Reactome
PKR-mediated signaling TAS Reactome
Post-translational protein modification TAS Reactome
Regulation of NF-kappa B signaling TAS Reactome
Regulation of TNFR1 signaling TAS Reactome
Response of endothelial cells to shear stress TAS Reactome
RIP-mediated NFkB activation via ZBP1 TAS Reactome
SARS-CoV Infections TAS Reactome
SARS-CoV-2 activates/modulates innate and adaptive immune responses TAS Reactome
SARS-CoV-2 Infection TAS Reactome
SARS-CoV-2-host interactions TAS Reactome
Signal Transduction TAS Reactome
Signaling by Interleukins TAS Reactome
Signaling by the B Cell Receptor (BCR) IEA Reactome
Signaling by the B Cell Receptor (BCR) TAS Reactome
SLC15A4:TASL-dependent IRF5 activation TAS Reactome
SUMO E3 ligases SUMOylate target proteins TAS Reactome
SUMOylation TAS Reactome
SUMOylation of immune response proteins TAS Reactome
TAK1-dependent IKK and NF-kappa-B activation TAS Reactome
TCR signaling TAS Reactome
TICAM1, RIP1-mediated IKK complex recruitment TAS Reactome
TNF signaling TAS Reactome
TNFR1-induced NF-kappa-B signaling pathway TAS Reactome
Toll Like Receptor 10 (TLR10) Cascade TAS Reactome
Toll Like Receptor 2 (TLR2) Cascade TAS Reactome
Toll Like Receptor 3 (TLR3) Cascade TAS Reactome
Toll Like Receptor 4 (TLR4) Cascade TAS Reactome
Toll Like Receptor 5 (TLR5) Cascade TAS Reactome
Toll Like Receptor 7/8 (TLR7/8) Cascade TAS Reactome
Toll Like Receptor 9 (TLR9) Cascade TAS Reactome
Toll Like Receptor TLR1:TLR2 Cascade TAS Reactome
Toll Like Receptor TLR6:TLR2 Cascade TAS Reactome
Toll-like Receptor Cascades TAS Reactome
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation TAS Reactome
TRAF6 mediated NF-kB activation TAS Reactome
TRIF (TICAM1)-mediated TLR4 signaling TAS Reactome
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells TAS Reactome
Ub-specific processing proteases TAS Reactome
Viral Infection Pathways TAS Reactome
ZBP1(DAI) mediated induction of type I IFNs TAS Reactome





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