Gene description for MIOS
Gene name missing oocyte, meiosis regulator, homolog (Drosophila)
Gene symbol MIOS
Other names/aliases -
Species Homo sapiens
 Database cross references - MIOS
ExoCarta ExoCarta_54468
Vesiclepedia VP_54468
Entrez Gene 54468
HGNC 21905
MIM 615359
UniProt Q9NXC5  
 MIOS identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for MIOS
Molecular Function
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
Biological Process
    protein-containing complex localization GO:0031503 IMP
    cellular response to nutrient levels GO:0031669 IDA
    central nervous system myelin formation GO:0032289 IEA
    cellular response to amino acid starvation GO:0034198 IBA
    cellular response to amino acid starvation GO:0034198 IMP
    oligodendrocyte differentiation GO:0048709 ISS
    oligodendrocyte progenitor proliferation GO:0070444 ISS
    negative regulation of TORC1 signaling GO:1904262 NAS
    positive regulation of TORC1 signaling GO:1904263 IBA
    positive regulation of TORC1 signaling GO:1904263 IDA
    positive regulation of TORC1 signaling GO:1904263 NAS
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IBA
    lysosomal membrane GO:0005765 HDA
    lysosomal membrane GO:0005765 IDA
    lysosomal membrane GO:0005765 TAS
    cytosol GO:0005829 IDA
    cell junction GO:0030054 IDA
    GATOR2 complex GO:0061700 IDA
    GATOR2 complex GO:0061700 NAS
 Experiment description of studies that identified MIOS in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for MIOS
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KLHL20  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 CCT7 10574
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 MECP2 4204
Affinity Capture-MS Homo sapiens
4 KPTN  
Affinity Capture-Western Homo sapiens
5 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
6 RRAGA 10670
Affinity Capture-Western Homo sapiens
7 MFAP5  
Affinity Capture-MS Homo sapiens
8 SIRT6  
Affinity Capture-MS Homo sapiens
9 NPRL2  
Affinity Capture-Western Homo sapiens
10 GATSL2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
11 RAB7A 7879
Proximity Label-MS Homo sapiens
12 AIPL1  
Affinity Capture-MS Homo sapiens
13 PAEP  
Affinity Capture-MS Homo sapiens
14 FKBP15 23307
Affinity Capture-MS Homo sapiens
15 SEC13 6396
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 DOK3 79930
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 PPM1H  
Proximity Label-MS Homo sapiens
18 BBS7 55212
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 RAB9A 9367
Proximity Label-MS Homo sapiens
20 LGALS3BP 3959
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 RARRES3  
Affinity Capture-MS Homo sapiens
22 FAM19A4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 DEPDC5  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
24 CUL3 8452
Affinity Capture-MS Homo sapiens
25 SQSTM1 8878
Proximity Label-MS Homo sapiens
26 LAMP2 3920
Proximity Label-MS Homo sapiens
27 CCT2 10576
Affinity Capture-MS Homo sapiens
28 PARK2  
Affinity Capture-MS Homo sapiens
29 SUPT5H 6829
Affinity Capture-MS Homo sapiens
30 PATZ1  
Affinity Capture-MS Homo sapiens
31 RRAGC 64121
Affinity Capture-Western Homo sapiens
32 BLM 641
Affinity Capture-MS Homo sapiens
33 LPXN 9404
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 SESN1  
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
35 RFPL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 GATSL3 652968
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
37 RFPL4B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 WDR24  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
39 HECW2  
Affinity Capture-MS Homo sapiens
40 NTRK1 4914
Affinity Capture-MS Homo sapiens
41 RXRA 6256
Affinity Capture-MS Homo sapiens
42 EGFR 1956
Negative Genetic Homo sapiens
43 Sesn2  
Affinity Capture-MS Mus musculus
44 FGFR1OP  
Affinity Capture-MS Homo sapiens
45 SESN3  
Reconstituted Complex Homo sapiens
46 LAMP1 3916
Affinity Capture-Western Homo sapiens
47 WDR59 79726
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
48 SHARPIN  
Affinity Capture-MS Homo sapiens
49 ARRDC3 57561
Affinity Capture-MS Homo sapiens
50 PFDN4 5203
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 SEH1L 81929
Affinity Capture-MS Homo sapiens
52 HECTD1 25831
Affinity Capture-MS Homo sapiens
53 RNF157 114804
Affinity Capture-MS Homo sapiens
54 RBBP5 5929
Affinity Capture-MS Homo sapiens
55 SESN2 83667
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
56 SZT2 23334
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
57 RAE1 8480
Affinity Capture-MS Homo sapiens
58 RGS20 8601
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 FAF1 11124
Affinity Capture-MS Homo sapiens
60 PDE5A 8654
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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