ExoCarta: Gene summary

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Gene description for CSNK1E
Gene name	casein kinase 1, epsilon
Gene symbol	CSNK1E
Other names/aliases	CKIepsilon HCKIE
Species	Homo sapiens
Database cross references - CSNK1E
ExoCarta	ExoCarta_1454
Vesiclepedia	VP_1454
Entrez Gene	1454
HGNC	2453
MIM	600863
UniProt	P49674
CSNK1E identified in sEVs derived from the following tissue/cell type
Retinal pigment epithelial cells	35333565
Retinal pigment epithelial cells	35333565

Gene ontology annotations for CSNK1E

Molecular Function
	RNA binding	GO:0003723	HDA
	protein kinase activity	GO:0004672	IDA
	protein kinase activity	GO:0004672	ISS
	protein serine/threonine kinase activity	GO:0004674	IBA
	protein serine/threonine kinase activity	GO:0004674	IDA
	protein serine/threonine kinase activity	GO:0004674	TAS
	3-phosphoinositide-dependent protein kinase activity	GO:0004676	IEA
	DNA-dependent protein kinase activity	GO:0004677	IEA
	AMP-activated protein kinase activity	GO:0004679	IEA
	eukaryotic translation initiation factor 2alpha kinase activity	GO:0004694	IEA
	ribosomal protein S6 kinase activity	GO:0004711	IEA
	protein binding	GO:0005515	IPI
	ATP binding	GO:0005524	IEA
	histone H3S10 kinase activity	GO:0035175	IEA
	histone H3T11 kinase activity	GO:0035402	IEA
	histone H3T6 kinase activity	GO:0035403	IEA
	histone H2AXS139 kinase activity	GO:0035979	IEA
	histone H3S28 kinase activity	GO:0044022	IEA
	histone H4S1 kinase activity	GO:0044023	IEA
	histone H2AS1 kinase activity	GO:0044024	IEA
	histone H2BS14 kinase activity	GO:0044025	IEA
	histone H3T3 kinase activity	GO:0072354	IEA
	histone H2AS121 kinase activity	GO:0072371	IEA
	Rho-dependent protein serine/threonine kinase activity	GO:0072518	IEA
	protein serine kinase activity	GO:0106310	IEA
	histone H2BS36 kinase activity	GO:0140823	IEA
	histone H3S57 kinase activity	GO:0140855	IEA
	histone H3T45 kinase activity	GO:0140857	IEA
	histone H2AT120 kinase activity	GO:1990244	IEA
Biological Process
	DNA repair	GO:0006281	TAS
	chromatin remodeling	GO:0006338	IEA
	protein phosphorylation	GO:0006468	IDA
	protein phosphorylation	GO:0006468	ISS
	endocytosis	GO:0006897	IBA
	signal transduction	GO:0007165	IBA
	protein localization	GO:0008104	IEA
	negative regulation of Wnt signaling pathway	GO:0030178	IEA
	negative regulation of protein binding	GO:0032091	IDA
	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	GO:0032436	IBA
	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	GO:0032436	ISS
	regulation of protein localization	GO:0032880	IDA
	circadian regulation of gene expression	GO:0032922	ISS
	regulation of circadian rhythm	GO:0042752	ISS
	circadian behavior	GO:0048512	IEA
	canonical Wnt signaling pathway	GO:0060070	IDA
	canonical Wnt signaling pathway	GO:0060070	IGI
	canonical Wnt signaling pathway	GO:0060070	IMP
	positive regulation of canonical Wnt signaling pathway	GO:0090263	IBA
	positive regulation of amyloid-beta formation	GO:1902004	IEA
	cellular response to nerve growth factor stimulus	GO:1990090	IEA
	positive regulation of non-canonical Wnt signaling pathway	GO:2000052	IC
Subcellular Localization
	nucleus	GO:0005634	IBA
	nucleus	GO:0005634	ISS
	nucleoplasm	GO:0005654	TAS
	cytoplasm	GO:0005737	IBA
	cytoplasm	GO:0005737	IDA
	cytosol	GO:0005829	TAS
	growth cone	GO:0030426	IEA
	neuronal cell body	GO:0043025	IEA
	ribonucleoprotein complex	GO:1990904	IEA

Experiment description of studies that identified CSNK1E in sEVs

Experiment ID

834

MISEV standards
✔ EM	Biophysical techniques
✔ LAMP2\|CD63\|FLOT1\|ITGA2B\|ICAM1\|CD9\|CD151\|TFRC\|RAB5A\|GAPDH\|AQP1\|TSG101	Enriched markers
✔ CANX	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

35333565

Organism

Homo sapiens

Experiment description

LAMP2A regulates the loading of proteins into exosomes

Authors

"Ferreira JV, da Rosa Soares A, Ramalho J, MÃ¡ximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, GirÃ£o H, van Niel G, Pereira P"

Journal name

Sci Adv

Publication year

2022

Sample

Retinal pigment epithelial cells

Sample name

ARPE-19

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectrometry

Experiment ID

835

MISEV standards
✔ EM	Biophysical techniques
✔ CD63\|FLOT1\|ITGA2B\|ICAM1\|CD9\|CD151\|TFRC\|RAB5A\|GAPDH\|AQP1\|TSG101	Enriched markers
✔ CANX	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

35333565

Organism

Homo sapiens

Experiment description

LAMP2A regulates the loading of proteins into exosomes

Authors

"Ferreira JV, da Rosa Soares A, Ramalho J, MÃ¡ximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, GirÃ£o H, van Niel G, Pereira P"

Journal name

Sci Adv

Publication year

2022

Sample

Retinal pigment epithelial cells

Sample name

ARPE-19

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectrometry

Protein-protein interactions for CSNK1E

Protein Interactor

ExoCarta ID

Identification method

PubMed

Species

Csnk1d

Affinity Capture-MS

Mus musculus

RNF149

284996

Affinity Capture-MS

Homo sapiens

INSIG1

Affinity Capture-MS

Homo sapiens

RYK

6259

Affinity Capture-MS

Homo sapiens

ARHGAP21

57584

Affinity Capture-MS

Homo sapiens

UBE2H

7328

Affinity Capture-MS

Homo sapiens

SLIT2

9353

Affinity Capture-MS

Homo sapiens

TMEM208

Affinity Capture-MS

Homo sapiens

Edc4

Affinity Capture-MS

Mus musculus

TRIM3

10612

Affinity Capture-MS		Homo sapiens
Two-hybrid		Homo sapiens
Affinity Capture-MS		Homo sapiens

PER1

Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Reconstituted Complex		Homo sapiens
Two-hybrid		Homo sapiens
Biochemical Activity		Homo sapiens
Affinity Capture-MS		Homo sapiens
Two-hybrid		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

PHF6

Affinity Capture-MS

Homo sapiens

SNX24

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

OCLN

100506658

Two-hybrid		Homo sapiens
Reconstituted Complex		Homo sapiens
Co-localization		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Biochemical Activity		Homo sapiens

SEC16A

9919

Affinity Capture-MS

Homo sapiens

AES

166

Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Affinity Capture-Western		Homo sapiens

SQSTM1

8878

Proximity Label-MS

Homo sapiens

ARHGAP26

23092

Affinity Capture-MS

Homo sapiens

CSNK1A1

1452

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

APC

Co-localization

Homo sapiens

FAM110C

Two-hybrid		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

DEC1

Two-hybrid

Homo sapiens

PPP1CC

5501

Two-hybrid

Homo sapiens

RBX1

9978

Two-hybrid

Homo sapiens

BYSL

705

Co-fractionation

Homo sapiens

USP9X

8239

Affinity Capture-MS

Homo sapiens

PRPF3

Affinity Capture-MS

Homo sapiens

DVL3

1857

Two-hybrid		Homo sapiens
Two-hybrid		Homo sapiens
Two-hybrid		Homo sapiens

PPP1R10

Affinity Capture-MS

Homo sapiens

FAXC

Affinity Capture-MS

Homo sapiens

CCDC61

Affinity Capture-MS

Homo sapiens

APP

351

Reconstituted Complex		Homo sapiens
Reconstituted Complex		Homo sapiens

ZNF618

Two-hybrid		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

HMMR

Affinity Capture-MS

Homo sapiens

LRPAP1

4043

Affinity Capture-MS

Homo sapiens

TCEB3

6924

Affinity Capture-MS

Homo sapiens

MIER1

Affinity Capture-MS

Homo sapiens

TEX264

51368

Affinity Capture-MS

Homo sapiens

BBS10

Two-hybrid

Homo sapiens

ATPIF1

93974

Affinity Capture-MS

Homo sapiens

PPP2R5D

5528

Two-hybrid

Homo sapiens

USP39

10713

Co-fractionation

Homo sapiens

RASAL2

9462

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

FAM83D

81610

Two-hybrid		Homo sapiens
Affinity Capture-MS		Homo sapiens

ANKRD49

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

ANKRD6

Affinity Capture-Western

Homo sapiens

CPSF7

79869

Affinity Capture-MS

Homo sapiens

RPS4Y2

140032

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

NCOA3

Affinity Capture-Western		Homo sapiens
Biochemical Activity		Homo sapiens

DDX58

23586

Affinity Capture-RNA

Homo sapiens

TIAM1

Affinity Capture-MS

Homo sapiens

ZSWIM8

23053

Affinity Capture-MS

Homo sapiens

FAM207A

Affinity Capture-MS

Homo sapiens

C2orf44

Two-hybrid

Homo sapiens

TULP3

7289

Affinity Capture-MS

Homo sapiens

PDIA6

10130

Affinity Capture-MS

Homo sapiens

NUSAP1

51203

Affinity Capture-MS

Homo sapiens

CSNK1D

1453

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

PCM1

5108

Proximity Label-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

GTSE1

51512

Affinity Capture-MS

Homo sapiens

LDLRAD4

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

MAVS

57506

Affinity Capture-Western

Homo sapiens

PPP6R3

55291

Affinity Capture-MS

Homo sapiens

ARHGAP22

58504

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

MRPL4

51073

Affinity Capture-MS

Homo sapiens

FOXP2

93986

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

WDR5

11091

Affinity Capture-MS

Homo sapiens

CSNK2B

1460

Two-hybrid

Homo sapiens

TNFRSF1B

Affinity Capture-MS

Homo sapiens

SGOL2

151246

Affinity Capture-MS

Homo sapiens

SSMEM1

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

KCNA4

Affinity Capture-MS

Homo sapiens

DVL2

1856

Affinity Capture-MS		Homo sapiens
Two-hybrid		Homo sapiens
Affinity Capture-MS		Homo sapiens

AHCYL1

10768

Affinity Capture-MS

Homo sapiens

KIF14

9928

Affinity Capture-MS

Homo sapiens

HSPA8

3312

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

LTBR

4055

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

NUP155

9631

Proximity Label-MS

Homo sapiens

UNC45A

55898

Affinity Capture-MS

Homo sapiens

TAZ

Affinity Capture-Western		Homo sapiens
Biochemical Activity		Homo sapiens

CADM4

199731

Two-hybrid

Homo sapiens

CLOCK

Two-hybrid		Homo sapiens
Affinity Capture-Luminescence		Homo sapiens

PPP1CA

5499

Biochemical Activity

Homo sapiens

NSUN2

54888

Co-fractionation

Homo sapiens

ARHGAP12

Affinity Capture-MS

Homo sapiens

DRICH1

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

BHLHE41

Two-hybrid

Homo sapiens

RORC

6097

Two-hybrid

Homo sapiens

MCC

4163

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Two-hybrid		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

PPP1R14A

94274

Reconstituted Complex

Homo sapiens

CRY1

Two-hybrid		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

CA2

760

Affinity Capture-MS

Homo sapiens

TAOK1

57551

Two-hybrid

Homo sapiens

KAT7

Two-hybrid

Homo sapiens

FAM110A

Two-hybrid		Homo sapiens
Two-hybrid		Homo sapiens

PSME1

5720

Affinity Capture-MS

Homo sapiens

TRA2A

29896

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

PPIL4

Affinity Capture-MS

Homo sapiens

MICU2

221154

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

100

ARHGEF1

9138

Two-hybrid

Homo sapiens

101

PNO1

56902

Co-fractionation		Homo sapiens
Two-hybrid		Homo sapiens

102

FOPNL

Affinity Capture-MS

Homo sapiens

103

FAM107A

Affinity Capture-MS

Homo sapiens

104

CEP72

Affinity Capture-MS

Homo sapiens

105

SMARCA4

6597

Affinity Capture-Western

Homo sapiens

106

FBLN7

Affinity Capture-MS

Homo sapiens

107

FARP2

9855

Affinity Capture-MS

Homo sapiens

108

RPA2

6118

Proximity Label-MS

Homo sapiens

109

TRIM21

6737

Affinity Capture-MS

Homo sapiens

110

NTRK1

4914

Affinity Capture-MS

Homo sapiens

111

RORA

Two-hybrid

Homo sapiens

112

ARHGAP11A

Affinity Capture-MS

Homo sapiens

113

SPRR2E

Affinity Capture-MS

Homo sapiens

114

Trp53

Biochemical Activity

Mus musculus

115

PTPRD

5789

Reconstituted Complex

Homo sapiens

116

BICD2

23299

Proximity Label-MS

Homo sapiens

117

TRIM11

Affinity Capture-MS

Homo sapiens

118

NOB1

Co-fractionation

Homo sapiens

119

CSNK1E

1454

Biochemical Activity		Homo sapiens
Two-hybrid		Homo sapiens
Biochemical Activity		Homo sapiens
Two-hybrid		Homo sapiens

120

HECTD1

25831

Affinity Capture-MS

Homo sapiens

121

FAM110B

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

122

SPANXN2

Affinity Capture-MS

Homo sapiens

123

LYAR

55646

Affinity Capture-MS

Homo sapiens

124

CUL2

8453

Affinity Capture-MS

Homo sapiens

125

YAP1

10413

Affinity Capture-Western		Homo sapiens
Biochemical Activity		Homo sapiens

126

REST

5978

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

127

SNX22

Affinity Capture-MS

Homo sapiens

128

CACNG4

Affinity Capture-MS

Homo sapiens

129

PIPSL

266971

Affinity Capture-MS

Homo sapiens

130

RMDN3

55177

Proximity Label-MS

Homo sapiens

131

Cry1

Affinity Capture-Western		Mus musculus
Affinity Capture-MS		Mus musculus

132

PPM1B

5495

Co-fractionation

Homo sapiens

133

UBE2S

Affinity Capture-MS

Homo sapiens

134

STK3

6788

Affinity Capture-MS

Homo sapiens

135

ATG4B

23192

Affinity Capture-MS

Homo sapiens

136

PER2

Two-hybrid		Homo sapiens
Affinity Capture-Western		Homo sapiens
Two-hybrid		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

137

VIPR2

Affinity Capture-MS

Homo sapiens

138

FAM83B

Affinity Capture-MS

Homo sapiens

139

GAPVD1

26130

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

140

PRDX4

10549

Affinity Capture-MS

Homo sapiens

141

CAMKK1

Affinity Capture-MS

Homo sapiens

142

TP53BP1

7158

Affinity Capture-MS

Homo sapiens

143

XPO1

7514

Affinity Capture-MS

Homo sapiens

144

SMARCD1

6602

Affinity Capture-MS

Homo sapiens

145

FAM83A

Affinity Capture-MS

Homo sapiens

146

SEC13

6396

Affinity Capture-MS

Homo sapiens

147

UBXN7

26043

Affinity Capture-MS

Homo sapiens

148

SCG5

Affinity Capture-MS

Homo sapiens

149

EIF1AD

84285

Affinity Capture-MS

Homo sapiens

150

GTF3C1

Two-hybrid

Homo sapiens

151

PRKAR2A

5576

Affinity Capture-MS

Homo sapiens

152

DBNDD2

Affinity Capture-Western		Homo sapiens
Two-hybrid		Homo sapiens

153

CD6

923

Affinity Capture-MS

Homo sapiens

154

TNFRSF1A

7132

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

155

CUL3

8452

Affinity Capture-MS

Homo sapiens

156

CTTN

2017

Affinity Capture-MS

Homo sapiens

157

CCNT1

Affinity Capture-MS

Homo sapiens

158

FKBP8

23770

Proximity Label-MS

Homo sapiens

159

RAB39B

116442

Affinity Capture-MS

Homo sapiens

160

PLD5

Affinity Capture-MS

Homo sapiens

161

TMEM74

Affinity Capture-MS

Homo sapiens

162

TRAF3

7187

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Biochemical Activity		Homo sapiens

163

Cep152

Affinity Capture-MS

Mus musculus

164

LPIN1

23175

Affinity Capture-Western

Homo sapiens

165

NXF2

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

166

Csnk1e

Affinity Capture-MS

Mus musculus

167

PRKACA

5566

Proximity Label-MS

Homo sapiens

168

PIP4K2A

5305

Affinity Capture-MS

Homo sapiens

169

Cep72

Affinity Capture-MS

Mus musculus

170

PER3

Affinity Capture-Western

Homo sapiens

171

TACO1

Affinity Capture-MS

Homo sapiens

172

MYC

Dosage Lethality

Homo sapiens

173

Uso1

56041

Affinity Capture-MS

Mus musculus

174

DBNDD1

Affinity Capture-MS

Homo sapiens

175

SAV1

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

176

NLRP1

Co-fractionation

Homo sapiens

177

OFD1

8481

Affinity Capture-MS

Homo sapiens

178

TNS2

23371

Two-hybrid

Homo sapiens

179

NDC80

10403

Proximity Label-MS

Homo sapiens

180

MYCN

Affinity Capture-MS		Homo sapiens
Synthetic Growth Defect		Homo sapiens

181

TCEB2

6923

Affinity Capture-MS

Homo sapiens

182

BICD1

636

Proximity Label-MS

Homo sapiens

183

CRY2

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

184

CACNG5

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

185

Kctd5

Affinity Capture-MS

Mus musculus

186

CLTC

1213

Affinity Capture-MS

Homo sapiens

187

UBE2D2

7322

Affinity Capture-MS

Homo sapiens

188

C7orf60

154743

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

189

BLOC1S5

63915

Affinity Capture-MS

Homo sapiens

190

FKBPL

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

191

RIPK4

Affinity Capture-MS

Homo sapiens

192

BAIAP2

10458

Affinity Capture-MS

Homo sapiens

193

BACH2

60468

Affinity Capture-MS

Homo sapiens

194

ZNF227

Two-hybrid

Homo sapiens

195

ARNTL

Two-hybrid		Homo sapiens
Biochemical Activity		Homo sapiens

196

FTL

2512

Affinity Capture-MS

Homo sapiens

197

RNF43

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Proximity Label-MS		Homo sapiens

198

NUDT21

11051

Affinity Capture-MS

Homo sapiens

199

SPICE1

Affinity Capture-MS

Homo sapiens

200

KIF2A

3796

Affinity Capture-MS

Homo sapiens

201

DVL1

1855

Affinity Capture-Western

Homo sapiens

202

FBXW11

Two-hybrid

Homo sapiens

203

PPP2R5E

5529

Two-hybrid

Homo sapiens

204

FBP1

2203

Two-hybrid

Homo sapiens

205

Bap1

Affinity Capture-MS

Mus musculus

206

KIAA0753

Affinity Capture-MS

Homo sapiens

207

AHCYL2

23382

Affinity Capture-MS

Homo sapiens

208

ZMYM6NB

Affinity Capture-MS

Homo sapiens

209

TP53

7157

Co-localization

Homo sapiens

210

ADAM22

Affinity Capture-MS

Homo sapiens

211

VPS13B

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

212

UQCC1

55245

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

213

C9orf114

Affinity Capture-MS

Homo sapiens

214

PCMT1

5110

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

215

KLHDC3

Affinity Capture-MS

Homo sapiens

216

SDCCAG3

Two-hybrid

Homo sapiens

217

FAM199X

139231

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

218

RP2

6102

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

219

RPS21

6227

Affinity Capture-MS

Homo sapiens

220

TMA16

Affinity Capture-MS

Homo sapiens

221

KNOP1

400506

Affinity Capture-MS

Homo sapiens

222

CAPZA2

830

Affinity Capture-MS

Homo sapiens

223

BID

Co-localization

Homo sapiens

224

ELAVL1

1994

Affinity Capture-RNA

Homo sapiens

225

INSIG2

Affinity Capture-MS

Homo sapiens

226

PRMT5

10419

Affinity Capture-MS

Homo sapiens

227

FAM83H

286077

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

228

TMLHE

55217

Affinity Capture-MS

Homo sapiens

229

AXIN1

Phenotypic Suppression		Homo sapiens
Two-hybrid		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens

230

PRKAR2B

5577

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

231

MTA2

9219

Affinity Capture-MS

Homo sapiens

232

ZMYND8

23613

Two-hybrid

Homo sapiens

233

RNF7

Affinity Capture-MS

Homo sapiens

234

MTMR4

Affinity Capture-MS

Homo sapiens

235

STOX2

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

236

KLHL42

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

237

JAK3

3718

Affinity Capture-MS

Homo sapiens

238

CEP131

22994

Affinity Capture-MS

Homo sapiens

239

FAM110D

Affinity Capture-MS

Homo sapiens

240

DHX16

8449

Co-fractionation

Homo sapiens

241

RAD54B

Two-hybrid

Homo sapiens

242

ALYREF

10189

Co-fractionation

Homo sapiens

243

BTBD1

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

244

KDELR2

11014

Affinity Capture-MS

Homo sapiens

245

MAPK9

5601

Affinity Capture-MS

Homo sapiens

246

ACACA

Affinity Capture-MS

Homo sapiens

247

ZCCHC10

Affinity Capture-MS

Homo sapiens

248

HES1

3280

Two-hybrid

Homo sapiens

249

WDR90

Affinity Capture-MS

Homo sapiens

250

DDX42

11325

Affinity Capture-MS

Homo sapiens

251

PDE4DIP

9659

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

252

PRPF4

9128

Affinity Capture-MS

Homo sapiens

253

POTEF

728378

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

254

CACNG2

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

255

C9orf72

Affinity Capture-MS

Homo sapiens

256

DTD1

92675

Co-fractionation

Homo sapiens

257

CKAP4

10970

Affinity Capture-MS

Homo sapiens

258

ATOH1

Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens

259

PRMT1

3276

Affinity Capture-MS

Homo sapiens

260

USP9Y

8287

Affinity Capture-MS

Homo sapiens

261

NR1D2

Two-hybrid

Homo sapiens

262

CTNND1

1500

Affinity Capture-Western

Homo sapiens

View the network

Pathways in which CSNK1E is involved

Pathway	Evidence	Source
Anchoring of the basal body to the plasma membrane	TAS	Reactome
AURKA Activation by TPX2	TAS	Reactome
Cell Cycle	TAS	Reactome
Cell Cycle, Mitotic	TAS	Reactome
Centrosome maturation	TAS	Reactome
Cilium Assembly	TAS	Reactome
Circadian Clock	IEA	Reactome
G2/M Transition	TAS	Reactome
Loss of Nlp from mitotic centrosomes	TAS	Reactome
Loss of proteins required for interphase microtubule organization from the centrosome	TAS	Reactome
M Phase	TAS	Reactome
Major pathway of rRNA processing in the nucleolus and cytosol	TAS	Reactome
Metabolism of RNA	TAS	Reactome
Mitotic G2-G2/M phases	TAS	Reactome
Mitotic Prometaphase	TAS	Reactome
Organelle biogenesis and maintenance	TAS	Reactome
Recruitment of mitotic centrosome proteins and complexes	TAS	Reactome
Recruitment of NuMA to mitotic centrosomes	TAS	Reactome
Regulation of PLK1 Activity at G2/M Transition	TAS	Reactome
rRNA processing	TAS	Reactome
rRNA processing in the nucleus and cytosol	TAS	Reactome
Signal Transduction	TAS	Reactome
Signaling by WNT	TAS	Reactome
TCF dependent signaling in response to WNT	TAS	Reactome
WNT mediated activation of DVL	TAS	Reactome

Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here