Gene description for HIBCH
Gene name 3-hydroxyisobutyryl-CoA hydrolase
Gene symbol HIBCH
Other names/aliases HIBYLCOAH
Species Homo sapiens
 Database cross references - HIBCH
ExoCarta ExoCarta_26275
Vesiclepedia VP_26275
Entrez Gene 26275
HGNC 4908
MIM 610690
UniProt Q6NVY1  
 HIBCH identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for HIBCH
Molecular Function
    3-hydroxyisobutyryl-CoA hydrolase activity GO:0003860 EXP
    3-hydroxyisobutyryl-CoA hydrolase activity GO:0003860 IBA
    3-hydroxyisobutyryl-CoA hydrolase activity GO:0003860 IDA
Biological Process
    valine catabolic process GO:0006574 IBA
    valine catabolic process GO:0006574 IEA
    branched-chain amino acid catabolic process GO:0009083 TAS
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IDA
    mitochondrial matrix GO:0005759 TAS
 Experiment description of studies that identified HIBCH in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for HIBCH
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Co-fractionation Homo sapiens
2 GSX1  
Affinity Capture-MS Homo sapiens
3 CLPP 8192
Proximity Label-MS Homo sapiens
4 LYRM5  
Affinity Capture-MS Homo sapiens
5 CS 1431
Proximity Label-MS Homo sapiens
6 ALDH7A1 501
Co-fractionation Homo sapiens
7 CLIC1 1192
Co-fractionation Homo sapiens
8 TSFM 10102
Proximity Label-MS Homo sapiens
9 UMPS 7372
Co-fractionation Homo sapiens
10 SCRT2  
Affinity Capture-MS Homo sapiens
11 DDX54 79039
Affinity Capture-MS Homo sapiens
12 SOD1 6647
Co-fractionation Homo sapiens
13 CAB39 51719
Co-fractionation Homo sapiens
14 LSM12 124801
Co-fractionation Homo sapiens
15 NME1-NME2 654364
Co-fractionation Homo sapiens
16 PSME3 10197
Co-fractionation Homo sapiens
17 OXLD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 NME2 4831
Co-fractionation Homo sapiens
19 TMEM184A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 CENPM  
Affinity Capture-MS Homo sapiens
21 PRCP 5547
Co-fractionation Homo sapiens
22 POP4 10775
Affinity Capture-MS Homo sapiens
23 CYP1A1  
Affinity Capture-MS Homo sapiens
24 ECI1 1632
Co-fractionation Homo sapiens
25 COX8A  
Proximity Label-MS Homo sapiens
26 CIART  
Affinity Capture-MS Homo sapiens
27 ACADVL 37
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 IRF2BPL 64207
Co-fractionation Homo sapiens
29 C21orf33  
Proximity Label-MS Homo sapiens
30 SOX2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 PRR19  
Affinity Capture-MS Homo sapiens
32 FLCN 201163
Affinity Capture-MS Homo sapiens
33 CLIC5 53405
Co-fractionation Homo sapiens
34 GATC  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 HOXC5  
Affinity Capture-MS Homo sapiens
36 ACAD9 28976
Affinity Capture-MS Homo sapiens
37 ACOT9 23597
Co-fractionation Homo sapiens
38 TBRG4 9238
Proximity Label-MS Homo sapiens
39 UFM1 51569
Co-fractionation Homo sapiens
40 USP47 55031
Affinity Capture-MS Homo sapiens
41 GTF2E2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 ARRB1 408
Affinity Capture-MS Homo sapiens
43 ACOT1 641371
Co-fractionation Homo sapiens
44 KIAA0391  
Affinity Capture-MS Homo sapiens
45 HNRNPH2 3188
Co-fractionation Homo sapiens
46 ACADM 34
Co-fractionation Homo sapiens
47 RPL35A 6165
Affinity Capture-MS Homo sapiens
48 PPA2 27068
Co-fractionation Homo sapiens
49 MKRN2 23609
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 C1QBP 708
Proximity Label-MS Homo sapiens
51 DSTN 11034
Co-fractionation Homo sapiens
52 FH 2271
Co-fractionation Homo sapiens
53 C12orf10 60314
Co-fractionation Homo sapiens
54 ALDH6A1 4329
Co-fractionation Homo sapiens
55 NAP1L2  
Affinity Capture-MS Homo sapiens
56 CLIC4 25932
Co-fractionation Homo sapiens
57 NEDD8 4738
Co-fractionation Homo sapiens
58 H2AFX 3014
Affinity Capture-MS Homo sapiens
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