Gene description for SLC22A12
Gene name solute carrier family 22 (organic anion/urate transporter), member 12
Gene symbol SLC22A12
Other names/aliases OAT4L
RST
URAT1
Species Homo sapiens
 Database cross references - SLC22A12
ExoCarta ExoCarta_116085
Vesiclepedia VP_116085
Entrez Gene 116085
HGNC 17989
MIM 607096
UniProt Q96S37  
 SLC22A12 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for SLC22A12
Molecular Function
    urate transmembrane transporter activity GO:0015143 IDA
    urate transmembrane transporter activity GO:0015143 TAS
    PDZ domain binding GO:0030165 IPI
Biological Process
    monoatomic ion transport GO:0006811 IEA
    response to xenobiotic stimulus GO:0009410 IDA
    organic anion transport GO:0015711 IBA
    urate transport GO:0015747 IDA
    urate transport GO:0015747 IMP
    cellular homeostasis GO:0019725 NAS
    cellular response to insulin stimulus GO:0032869 IEA
    urate metabolic process GO:0046415 IMP
    transmembrane transport GO:0055085 IEA
    renal urate salt excretion GO:0097744 IEA
Subcellular Localization
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 IMP
    plasma membrane GO:0005886 TAS
    membrane GO:0016020 IDA
    apical plasma membrane GO:0016324 IDA
    brush border membrane GO:0031526 ISS
    brush border membrane GO:0031526 NAS
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified SLC22A12 in exosomes
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for SLC22A12
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ATP5B 506
Affinity Capture-MS Homo sapiens
2 NDUFA13 51079
Affinity Capture-MS Homo sapiens
3 SMAP2 64744
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 PDZK1 5174
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml



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