Gene description for COL1A2
Gene name collagen, type I, alpha 2
Gene symbol COL1A2
Other names/aliases OI4
Species Homo sapiens
 Database cross references - COL1A2
ExoCarta ExoCarta_1278
Entrez Gene 1278
HGNC 2198
MIM 120160
UniProt P08123  
 COL1A2 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for COL1A2
Molecular Function
    identical protein binding GO:0042802 IDA
    protein binding GO:0005515 IPI
    protein binding, bridging GO:0030674 IMP
    platelet-derived growth factor binding GO:0048407 IDA
    extracellular matrix structural constituent GO:0005201 NAS
    metal ion binding GO:0046872 IEA
    SMAD binding GO:0046332 IEA
Biological Process
    collagen catabolic process GO:0030574 TAS
    extracellular matrix organization GO:0030198 TAS
    blood vessel development GO:0001568 IMP
    cellular response to amino acid stimulus GO:0071230 IEA
    leukocyte migration GO:0050900 TAS
    extracellular matrix disassembly GO:0022617 TAS
    odontogenesis GO:0042476 NAS
    blood coagulation GO:0007596 TAS
    receptor-mediated endocytosis GO:0006898 TAS
    skin morphogenesis GO:0043589 IMP
    Rho protein signal transduction GO:0007266 IDA
    collagen fibril organization GO:0030199 IMP
    skeletal system development GO:0001501 IMP
    transforming growth factor beta receptor signaling pathway GO:0007179 IDA
    regulation of blood pressure GO:0008217 IMP
    platelet activation GO:0030168 TAS
    protein heterotrimerization GO:0070208 IEA
Subcellular Localization
    extracellular matrix GO:0031012 IDA
    collagen type I trimer GO:0005584 TAS
    extracellular space GO:0005615 IDA
    extracellular exosome GO:0070062 IDA
    extracellular region GO:0005576 TAS
    endoplasmic reticulum lumen GO:0005788 TAS
 Experiment description of studies that identified COL1A2 in exosomes
Experiment ID 126
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for COL1A2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 APP 351
Invitro Homo sapiens
2 FN1 2335
Invivo Homo sapiens
3 CD36 948
Invitro Homo sapiens
4 P4HB 5034
Invivo Homo sapiens
5 CD44 960
Invitro Homo sapiens
6 MMP9 4318
Invivo Homo sapiens
7 COL5A3  
Invivo Homo sapiens
Invivo Homo sapiens
8 BGN 633
Invitro Homo sapiens
9 TGFBI 7045
Invitro Homo sapiens
10 DCN 1634
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
11 ITGA2B 3674
Invivo Homo sapiens
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